GC3 of genes can be used as a proxy for isochore base composition: A reply to Elhaik et al.

Oliver K. Clay, Giorgio Bernardi

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

In an article published in these pages, Elhaik et al. (Elhaik E, Landan G, Graur D. 2009. Can GC content at third-codon positions be used as a proxy for isochore composition? Mol Biol Evol. 26:1829-1833) asked if GC3, the GC level of the third-codon positions in protein-coding genes, can be used as a "proxy" to estimate the GC level of the surrounding isochore. We use available data to directly answer this simple question in the affirmative and show how the use of indirect methods can lead to apparently conflicting conclusions. The answer reasserts that in human and other vertebrates, genes have a strong tendency to reside in compositionally corresponding isochores, which has far-reaching implications for genome structure and evolution.

Original languageEnglish (US)
Pages (from-to)21-23
Number of pages3
JournalMolecular Biology and Evolution
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2011

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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