Factors of the epidemiological triad that influence the persistence of human papilloma virus infection in women with systemic lupus erythematosus

S. Méndez-Martínez, M. García-Carrasco, E. A. Jiménez-Herrera, C. Mendoza-Pinto, I. Etchegaray-Morales, P. W. Barahona-Rubio, J. L. Gálvez-Romero, P. Munguía-Realpozo, C. O. Muñóz-Guarneros, M. L. Cedillo-Ramírez, S. E. Silva-Gómez, G. Linares-Fleites, A. Rojas-Vallaraga

Research output: Contribution to journalResearch Articlepeer-review

8 Scopus citations

Abstract

We studied the epidemiologic triad-related factors influencing human papilloma virus (HPV) persistence in Mexican women with systemic lupus erythematosus (SLE). Patients aged ≥18 years with SLE (American College of Rheumatology criteria), with and without HPV persistence, were selected. Groups were analyzed by (1) host: clinical disease characteristics; (2) agent: (I) infectious (prevalence, incidence, HPV genotype and co-infections (≥2 HPV genotypes or mycoplasmas)), (II) chemical (contraceptives and immunosuppressive drugs) and (III) physical (vitamin D deficiency) and (3) environment. A total of 121 SLE patients were selected over a two-year period. (1) Host: mean age 45.8 years and disease duration 12.7 years. (2) Agent: (I) infectious. HPV infection prevalence in the second sample was 26.4%, high-risk HPV genotypes 21.5% and co-infections 7.4%. HPV infection incidence was 13.2%, persistence 13.2% and clearance 15.7%. (II) Chemical: use of oral hormonal contraceptives 5% and immunosuppressive treatment 97.5%. (III) Physical: Vitamin D levels were similar in both groups. (3) Environment: (I) natural. A total of 60.6% of patients were residents of Puebla City. (II) Social: The mean education level was 10.9. Poverty levels were: III degree 52.4%, IV degree 28% and II degree 17%. (III) Cultural behavioral: Onset of sexual life was 20.5 years, 10% had ≥3 sexual partners and 51.2% were postmenopausal. In conclusion, no factor of the epidemiologic triad was associated with HPV infection prevalence.

Original languageEnglish (US)
Pages (from-to)1542-1546
Number of pages5
JournalLupus
Volume27
Issue number9
DOIs
StatePublished - Aug 1 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rheumatology

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