Exercise and postprandial lipemia: Effects on vascular health in inactive adults

Robinson Ramírez-Vélez, Mariá Correa-Rodríguez, Alejandra Tordecilla-Sanders, Viviana Aya-Aldana, Mikel Izquierdo, Jorge Enrique Correa-Bautista, Cristian Álvarez, Antonio Garcia-Hermoso

Research output: Contribution to journalArticle

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Abstract

Background: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. Methods: A randomized clinical trial was conducted in 20 healthy, inactive adults (31.6 ± 7.1 years). Participants followed the two exercise protocols for 12 weeks. To induce a state of postprandial lipemia (PPL), all subjects received a HFM. Endothelial function was measured using flow-mediated vasodilation (FMD), normalized brachial artery FMD (nFMD), aortic pulse wave velocity (PWV) and augmentation index (AIx). Plasma total cholesterol, high-density lipoprotein cholesterol (HDL-c), triglycerides and glucose were also measured. Results: The effects of a HFM were evaluated in a fasted state and 60, 120, 180, and 240 min postprandially. A significant decrease in serum glucose between 0 min (fasted state) and 120 min postprandially was found in the HIT group (P = 0.035). Likewise, FMD (%) was significantly different between the fasted state and 60 min after a HFM in the HIT group (P = 0.042). The total cholesterol response expressed as area under curve (AUC)(0-240) was lower following HIT than following MCT, but no significant differences were observed (8%, P > 0.05). Similarly, triglycerides AUC(0-240) was also lower after HIT compared with MCT, which trended towards significance (24%, P = 0.076). The AUC(0-240) for the glucose response was significantly lower following HIT than MCT (10%, P = 0.008). FMD and nFMD AUC(0-240) were significantly higher following HIT than following MCT (46.9%, P = 0.021 and 67.3%, P = 0.009, respectively). PWV AUC(0-240) did not differ following between the two exercise groups (2.3%, P > 0.05). Conclusions: Supervised exercise training mitigates endothelial dysfunction and glucose response induced by PPL. Exercise intensity plays an important role in these protective effects, and medium-term HIT may be more effective than MCT in reducing postprandial glucose levels and attenuating vascular impairment. Trial registration: ClinicalTrials.gov ID: NCT02738385 Date of registration: April 14, 2016.

Original languageEnglish (US)
Article number69
JournalLipids in Health and Disease
Volume17
Issue number1
DOIs
StatePublished - Apr 3 2018

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ramírez-Vélez, R., Correa-Rodríguez, M., Tordecilla-Sanders, A., Aya-Aldana, V., Izquierdo, M., Correa-Bautista, J. E., ... Garcia-Hermoso, A. (2018). Exercise and postprandial lipemia: Effects on vascular health in inactive adults. Lipids in Health and Disease, 17(1), [69]. https://doi.org/10.1186/s12944-018-0719-3
Ramírez-Vélez, Robinson ; Correa-Rodríguez, Mariá ; Tordecilla-Sanders, Alejandra ; Aya-Aldana, Viviana ; Izquierdo, Mikel ; Correa-Bautista, Jorge Enrique ; Álvarez, Cristian ; Garcia-Hermoso, Antonio. / Exercise and postprandial lipemia : Effects on vascular health in inactive adults. In: Lipids in Health and Disease. 2018 ; Vol. 17, No. 1.
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title = "Exercise and postprandial lipemia: Effects on vascular health in inactive adults",
abstract = "Background: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. Methods: A randomized clinical trial was conducted in 20 healthy, inactive adults (31.6 ± 7.1 years). Participants followed the two exercise protocols for 12 weeks. To induce a state of postprandial lipemia (PPL), all subjects received a HFM. Endothelial function was measured using flow-mediated vasodilation (FMD), normalized brachial artery FMD (nFMD), aortic pulse wave velocity (PWV) and augmentation index (AIx). Plasma total cholesterol, high-density lipoprotein cholesterol (HDL-c), triglycerides and glucose were also measured. Results: The effects of a HFM were evaluated in a fasted state and 60, 120, 180, and 240 min postprandially. A significant decrease in serum glucose between 0 min (fasted state) and 120 min postprandially was found in the HIT group (P = 0.035). Likewise, FMD ({\%}) was significantly different between the fasted state and 60 min after a HFM in the HIT group (P = 0.042). The total cholesterol response expressed as area under curve (AUC)(0-240) was lower following HIT than following MCT, but no significant differences were observed (8{\%}, P > 0.05). Similarly, triglycerides AUC(0-240) was also lower after HIT compared with MCT, which trended towards significance (24{\%}, P = 0.076). The AUC(0-240) for the glucose response was significantly lower following HIT than MCT (10{\%}, P = 0.008). FMD and nFMD AUC(0-240) were significantly higher following HIT than following MCT (46.9{\%}, P = 0.021 and 67.3{\%}, P = 0.009, respectively). PWV AUC(0-240) did not differ following between the two exercise groups (2.3{\%}, P > 0.05). Conclusions: Supervised exercise training mitigates endothelial dysfunction and glucose response induced by PPL. Exercise intensity plays an important role in these protective effects, and medium-term HIT may be more effective than MCT in reducing postprandial glucose levels and attenuating vascular impairment. Trial registration: ClinicalTrials.gov ID: NCT02738385 Date of registration: April 14, 2016.",
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Ramírez-Vélez, R, Correa-Rodríguez, M, Tordecilla-Sanders, A, Aya-Aldana, V, Izquierdo, M, Correa-Bautista, JE, Álvarez, C & Garcia-Hermoso, A 2018, 'Exercise and postprandial lipemia: Effects on vascular health in inactive adults', Lipids in Health and Disease, vol. 17, no. 1, 69. https://doi.org/10.1186/s12944-018-0719-3

Exercise and postprandial lipemia : Effects on vascular health in inactive adults. / Ramírez-Vélez, Robinson; Correa-Rodríguez, Mariá; Tordecilla-Sanders, Alejandra; Aya-Aldana, Viviana; Izquierdo, Mikel; Correa-Bautista, Jorge Enrique; Álvarez, Cristian; Garcia-Hermoso, Antonio.

In: Lipids in Health and Disease, Vol. 17, No. 1, 69, 03.04.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise and postprandial lipemia

T2 - Effects on vascular health in inactive adults

AU - Ramírez-Vélez, Robinson

AU - Correa-Rodríguez, Mariá

AU - Tordecilla-Sanders, Alejandra

AU - Aya-Aldana, Viviana

AU - Izquierdo, Mikel

AU - Correa-Bautista, Jorge Enrique

AU - Álvarez, Cristian

AU - Garcia-Hermoso, Antonio

PY - 2018/4/3

Y1 - 2018/4/3

N2 - Background: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. Methods: A randomized clinical trial was conducted in 20 healthy, inactive adults (31.6 ± 7.1 years). Participants followed the two exercise protocols for 12 weeks. To induce a state of postprandial lipemia (PPL), all subjects received a HFM. Endothelial function was measured using flow-mediated vasodilation (FMD), normalized brachial artery FMD (nFMD), aortic pulse wave velocity (PWV) and augmentation index (AIx). Plasma total cholesterol, high-density lipoprotein cholesterol (HDL-c), triglycerides and glucose were also measured. Results: The effects of a HFM were evaluated in a fasted state and 60, 120, 180, and 240 min postprandially. A significant decrease in serum glucose between 0 min (fasted state) and 120 min postprandially was found in the HIT group (P = 0.035). Likewise, FMD (%) was significantly different between the fasted state and 60 min after a HFM in the HIT group (P = 0.042). The total cholesterol response expressed as area under curve (AUC)(0-240) was lower following HIT than following MCT, but no significant differences were observed (8%, P > 0.05). Similarly, triglycerides AUC(0-240) was also lower after HIT compared with MCT, which trended towards significance (24%, P = 0.076). The AUC(0-240) for the glucose response was significantly lower following HIT than MCT (10%, P = 0.008). FMD and nFMD AUC(0-240) were significantly higher following HIT than following MCT (46.9%, P = 0.021 and 67.3%, P = 0.009, respectively). PWV AUC(0-240) did not differ following between the two exercise groups (2.3%, P > 0.05). Conclusions: Supervised exercise training mitigates endothelial dysfunction and glucose response induced by PPL. Exercise intensity plays an important role in these protective effects, and medium-term HIT may be more effective than MCT in reducing postprandial glucose levels and attenuating vascular impairment. Trial registration: ClinicalTrials.gov ID: NCT02738385 Date of registration: April 14, 2016.

AB - Background: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. Methods: A randomized clinical trial was conducted in 20 healthy, inactive adults (31.6 ± 7.1 years). Participants followed the two exercise protocols for 12 weeks. To induce a state of postprandial lipemia (PPL), all subjects received a HFM. Endothelial function was measured using flow-mediated vasodilation (FMD), normalized brachial artery FMD (nFMD), aortic pulse wave velocity (PWV) and augmentation index (AIx). Plasma total cholesterol, high-density lipoprotein cholesterol (HDL-c), triglycerides and glucose were also measured. Results: The effects of a HFM were evaluated in a fasted state and 60, 120, 180, and 240 min postprandially. A significant decrease in serum glucose between 0 min (fasted state) and 120 min postprandially was found in the HIT group (P = 0.035). Likewise, FMD (%) was significantly different between the fasted state and 60 min after a HFM in the HIT group (P = 0.042). The total cholesterol response expressed as area under curve (AUC)(0-240) was lower following HIT than following MCT, but no significant differences were observed (8%, P > 0.05). Similarly, triglycerides AUC(0-240) was also lower after HIT compared with MCT, which trended towards significance (24%, P = 0.076). The AUC(0-240) for the glucose response was significantly lower following HIT than MCT (10%, P = 0.008). FMD and nFMD AUC(0-240) were significantly higher following HIT than following MCT (46.9%, P = 0.021 and 67.3%, P = 0.009, respectively). PWV AUC(0-240) did not differ following between the two exercise groups (2.3%, P > 0.05). Conclusions: Supervised exercise training mitigates endothelial dysfunction and glucose response induced by PPL. Exercise intensity plays an important role in these protective effects, and medium-term HIT may be more effective than MCT in reducing postprandial glucose levels and attenuating vascular impairment. Trial registration: ClinicalTrials.gov ID: NCT02738385 Date of registration: April 14, 2016.

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Ramírez-Vélez R, Correa-Rodríguez M, Tordecilla-Sanders A, Aya-Aldana V, Izquierdo M, Correa-Bautista JE et al. Exercise and postprandial lipemia: Effects on vascular health in inactive adults. Lipids in Health and Disease. 2018 Apr 3;17(1). 69. https://doi.org/10.1186/s12944-018-0719-3