Cardiovascular disease in Latin American patients with systemic lupus erythematosus: A cross-sectional study and a systematic review

Jenny Amaya-Amaya, Juan Camilo Sarmiento-Monroy, Julián Caro-Moreno, Nicolás Molano-González, Rubén D. Mantilla, Adriana Rojas-Villarraga, Juan Manuel Anaya

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Objective. This study was performed to determine the prevalence of and associated risk factors for cardiovascular disease (CVD) in Latin American (LA) patients with systemic lupus erythematosus (SLE). Methods. First, a cross-sectional analytical study was conducted in 310 Colombian patients with SLE in whom CVD was assessed. Associated factors were examined by multivariate regression analyses. Second, a systematic review of the literature on CVD in SLE in LA was performed. Results. There were 133 (36.5%) Colombian SLE patients with CVD. Dyslipidemia, smoking, coffee consumption, and pleural effusion were positively associated with CVD. An independent effect of coffee consumption and cigarette on CVD was found regardless of gender and duration of disease. In the systematic review, 60 articles fulfilling the eligibility criteria were included. A wide range of CVD prevalence was found (4%-79.5%). Several studies reported ancestry, genetic factors, and polyautoimmunity as novel risk factors for such a condition. Conclusions. A high rate of CVD is observed in LA patients with SLE. Awareness of the observed risk factors should encourage preventive population strategies for CVD in patients with SLE aimed at facilitating the suppression of cigarette smoking and coffee consumption as well as at the tight control of dyslipidemia and other modifiable risk factors.

Original languageEnglish (US)
Article number794383
JournalAutoimmune Diseases
Volume2013
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Immunology and Microbiology (miscellaneous)

Fingerprint Dive into the research topics of 'Cardiovascular disease in Latin American patients with systemic lupus erythematosus: A cross-sectional study and a systematic review'. Together they form a unique fingerprint.

Cite this