Autoimmune Liver Disease Associated Uveitis: An Extrahepatic Manifestation or a Polyautoimmunity Phenomenon? Case Reports

Laura Zarate-Pinzón, Gabriela Flórez-Esparza, Camilo Andrés Rodríguez-Rodríguez, Luis A. Diez-Bahamón, Germán Mejía-Salgado, Carlos Cifuentes-González, Alejandra de-la-Torre

Research output: Contribution to journalResearch Articlepeer-review

Abstract

Purpose: To report two cases of non-granulomatous unilateral anterior uveitis in two female patients associated with autoimmune liver diseases (ALD), emphasizing the possibility of this rare coexistence as a polyautoimmunity phenomenon. Case descriptions: Case 1: An 18-year-old female with a history of congenital renal hypoplasia and metabolic syndrome presented with anterior uveitis in OS and a history of jaundice, blood elevated hepatic enzymes, and cholangioresonance compatible with primary sclerosing cholangitis (PSC). Laboratory work-up for additional autoimmune and infective causes were within normal limits. Case 2: An 58-year-old female presented an episode of anterior uveitis in OD and a history of Sjögren syndrome diagnosed at the age of 53, primary biliary cholangitis (PBC), systemic sclerosis, Raynaud’s phenomenon, bilateral sacroiliitis, and vitiligo, consistent with polyautoimmunity and multiple autoimmune syndrome. Conclusions: Uveitis rarely coexists with ALD. However, it is essential to recognize the possibility of polyautoimmunity in patients presenting with ophthalmic manifestations and a previous diagnosis of ALD, such as PSC or PBC.

Translated title of the contributionUveítis asociada a enfermedad hepática autoinmune: ¿Una manifestación extrahepática o un fenómeno de poliautoinmunidad? Casos clínicos
Original languageEnglish (US)
JournalOcular Immunology and Inflammation
DOIs
StatePublished - Apr 2 2024

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology

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