Abstract
Cellular apoptosis has been considered as the
main physiological mechanism underlying
neuronal demise associated to neurodegenerative
diseases. Apoptosis has also been described in
parenquimal and microvascular endothelium
in the acute phase of sepsis during multi-organic
dysfunction. Therefore, strategies aimed to prevent apoptosis (anti-apoptotic) represent a
valuable tool for prevention and/or retardation
of the appearance of clinical symptoms in these
disorders, which generate a large morbilitymortality,
social and economic burden worldwide.
The present review is aim to show that antiapoptotic
strategies hold a great therapeutic
potential. In this sense, we will review some of
these potential therapies such as caspase
inhibitors, activated protein C, Bcl-2 family and
the PI3K/Akt signalling pathway.
main physiological mechanism underlying
neuronal demise associated to neurodegenerative
diseases. Apoptosis has also been described in
parenquimal and microvascular endothelium
in the acute phase of sepsis during multi-organic
dysfunction. Therefore, strategies aimed to prevent apoptosis (anti-apoptotic) represent a
valuable tool for prevention and/or retardation
of the appearance of clinical symptoms in these
disorders, which generate a large morbilitymortality,
social and economic burden worldwide.
The present review is aim to show that antiapoptotic
strategies hold a great therapeutic
potential. In this sense, we will review some of
these potential therapies such as caspase
inhibitors, activated protein C, Bcl-2 family and
the PI3K/Akt signalling pathway.
| Translated title of the contribution | Apoptosis: Therapeutic target in neurodegeneration and sepsis |
|---|---|
| Original language | Spanish |
| Pages (from-to) | 186-205 |
| Number of pages | 20 |
| Journal | Revista Ciencias de la Salud |
| Volume | 3 |
| Issue number | 2 |
| State | Published - 2005 |