TY - JOUR
T1 - Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis
AU - Diaz, Francisco J.
AU - Rojas-Villarraga, Adriana
AU - Salazar, Juan C.
AU - Iglesias-Gamarra, Antonio
AU - Mantilla, Ruben D.
AU - Anaya, Juan Manuel
N1 - Funding Information:
This work was supported by Colciencias (1101-04-14156, to AIG, and 186/2007 to FJD and JCS); the Universidad Nacional de Colombia (DIB-809275); an unrestricted grant from Lafrancol SAS, and the School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia. We are indebted to Tom W.J. Huizinga for fruitful discussion and criticism, and to Oscar Ortega for his assistance.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/3
Y1 - 2011/3
N2 - Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA.
AB - Objectives: To determine factors influencing the age at onset of rheumatoid arthritis (RA). Methods: A sample of 152 Colombian patients was investigated. Hazard ratios (HRs) that measured the effect size of risk factors on the age at RA onset were computed by using Cox regression models. Results: Positive anti-CCP antibodies were associated with an increased risk of early RA onset (HR=1.60; 95% confidence interval, [1.06, 2.4]), whereas the presence of the protective 70DERAA74 sequence was associated with a delayed onset (HR=0.55; [0.33, 0.92]). After controlling for both anti-CCP antibodies and the 70DERAA74 sequence, the following variables did not influence significantly the age at RA onset: gender, ever cigarette smoking, family RA history, the TNF-308 A polymorphism, HLA shared epitope, and the presence of rheumatoid factor. Conclusion: Anti-CCP antibodies and the HLA-DRB1 70DERAA74 sequence influence the age at onset of RA.
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U2 - 10.1016/j.jbspin.2010.07.014
DO - 10.1016/j.jbspin.2010.07.014
M3 - Article
C2 - 20888281
AN - SCOPUS:79952250830
SN - 1297-319X
VL - 78
SP - 175
EP - 178
JO - Joint Bone Spine
JF - Joint Bone Spine
IS - 2
ER -