TY - JOUR
T1 - An interrupted time series analysis of parenteral antibiotic use in Colombia
AU - Pérez, Adriana
AU - Dennis, Rodolfo J.
AU - Rodríguez, Benigno
AU - Castro, Amparo Y.
AU - Delgado, Victor
AU - Lozano, Juan Manuel
AU - Castro, Maria Clara
N1 - Funding Information:
This work was supported by the International Clinical Epidemiology Network (INCLEN, grant #1004-97-6501) and by Pontificia Universidad Javeriana (grant #12-24-01-31). The authors would like to thank Dr Brian Strom, MD, MPH, for evaluating the initial study protocol, and are grateful as well to Carlos Arango MD, Hector Pulido, MD, and Albis Hani, MD, for their collaboration during the planning, development, and implementation of the intervention. We also wish to thank Edgar Gabriel Celis, MD, Maria del Pilar Bernal, MD, and Carlos Andres Cáceres, who assisted with data entry.
PY - 2003/10/1
Y1 - 2003/10/1
N2 - A University-based hospital in Bogotá, Colombia, developed and implemented an educational intervention to complement a new structured antibiotic order form. This intervention was performed after assessing the appropriateness of the observed antibiotic prescribing practices using a quasi-experimental study. An application of interrupted time series intervention analysis was conducted in three antibiotic groups (aminoglycosides, cephradine/cephalothin, and ceftazidime/cefotaxime) and their hospital weekly rate of incorrect prescriptions before and after the intervention. A fourth time series was defined on prophylactic antibiotic use in elective surgery. Preintervention models were used in the postintervention series to test for pre-post series level differences. An abrupt constant change was significant in the first, third, and fourth time series indicating a 47, 7.3, and 20% reduction of incorrect prescriptions after the intervention. We conclude that a structured antibiotic order form, coupled with graphic and educational interventions can improve antibiotic use in a university hospital.
AB - A University-based hospital in Bogotá, Colombia, developed and implemented an educational intervention to complement a new structured antibiotic order form. This intervention was performed after assessing the appropriateness of the observed antibiotic prescribing practices using a quasi-experimental study. An application of interrupted time series intervention analysis was conducted in three antibiotic groups (aminoglycosides, cephradine/cephalothin, and ceftazidime/cefotaxime) and their hospital weekly rate of incorrect prescriptions before and after the intervention. A fourth time series was defined on prophylactic antibiotic use in elective surgery. Preintervention models were used in the postintervention series to test for pre-post series level differences. An abrupt constant change was significant in the first, third, and fourth time series indicating a 47, 7.3, and 20% reduction of incorrect prescriptions after the intervention. We conclude that a structured antibiotic order form, coupled with graphic and educational interventions can improve antibiotic use in a university hospital.
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U2 - 10.1016/S0895-4356(03)00163-X
DO - 10.1016/S0895-4356(03)00163-X
M3 - Article
C2 - 14568634
AN - SCOPUS:0142057303
SN - 0895-4356
VL - 56
SP - 1013
EP - 1020
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 10
ER -