A mathematical model of medial collateral ligament repair: Migration, fibroblast proliferation and collagen formation

D. A. Garzón-Alvarado, R. P. Cárdenas Sandoval, J. C. Vanegas Acosta

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The partial rupture of ligament fibres leads to an injury known as grade 2 sprain. Wound healing after injury consists of four general stages: swelling, release of platelet-derived growth factor (PDGF), fibroblast migration and proliferation and collagen production. The aim of this paper is to present a mathematical model based on reaction-diffusion equations for describing the repair of the medial collateral ligament when it has suffered a grade 2 sprain. We have used the finite element method to solve the equations of this. The results have simulated the tissue swelling at the time of injury, predicted PDGF influence, the concentration of fibroblasts migrating towards the place of injury and reproduced the random orientation of immature collagen fibres. These results agree with experimental data reported by other authors. The model describes wound healing during the 9 days following such injury.

Original languageEnglish (US)
Pages (from-to)571-583
Number of pages13
JournalComputer Methods in Biomechanics and Biomedical Engineering
Volume15
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering
  • Human-Computer Interaction
  • Computer Science Applications

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