TY - JOUR
T1 - A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis
AU - Lopes, Livia Cristina Liporagi
AU - Guimarães, Allan J.
AU - De Cerqueira, Mariana Duarte
AU - Gómez, Beatriz L.
AU - Nosanchuk, Joshua D.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2010/7
Y1 - 2010/7
N2 - Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.
AB - Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.
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U2 - 10.1128/CVI.00033-10
DO - 10.1128/CVI.00033-10
M3 - Research Article
C2 - 20484567
AN - SCOPUS:77954382075
SN - 1556-6811
VL - 17
SP - 1155
EP - 1158
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 7
ER -