Serum pepsinogen I/II levels in patients with upper endoscopy of the digestive tract plus biopsy in third level institutions. Bogota

Project: Research project

Description

Gastric adenocarcinoma is the fifth most frequent cancer in the world and is the third cause of death in both sexes. In our environment, the majority of patients with gastric cancer are detected at an advanced stage. In the Colombian population there is limited evidence regarding Pepsinogen I and II levels as markers of pre-malignant lesions and gastric cancer. The aim is to establish the serum pepsinogen levels I, II, the pepsinogen quotient I/II will be calculated and the description will be made according to the results obtained in the upper endoscopy of the digestive tract with biopsy in patients who are taken to endoscopy by the gastroenterology service. Approximately 138 patients with endoscopy of digestive tract and biopsy will be included, estimated size to estimate a proportion. Descriptive statistics will be used according to the distribution of the variables. Averages or medians of pépsinogen I, II and I/II will be compared, according to their distribution in different groups of pathological diagnosis: healthy, acute gastritis, chronic gastritis, erosive gastritis, chronic atrophic gastritis, peptic ulcer, HVDA, low-grade dysplasia, high-grade dysplasia, adenocarcinoma in situ, early adenocarcinoma and late adenocarcinoma. For comparison of multiple patient groups, variance analysis (ANOVA) or Kruskal-Wallis test will be used depending on the distribution of pepsinogen values. To evaluate the relationship between sociodemographic or clinical variables and the pepsinogen ratio I/II, Pearson's chi-square or Fisher's exact test will be used. Transformations of the data will be made if necessary. It will be expected to generate a baseline of pepsinogen levels I and II as well as its relation I/II and explore its possible application in the early and non-invasive detection of gastric premalignant lesions in the Colombian population.

Layman's description

It is common for people to feel pain in the mouth of the stomach, fullness when they have eaten little, or reflux that causes them to cough after eating. These symptoms should be studied to find out why they are present. The best way so far is to perform an endoscopy to look at the stomach for causes that may cause these symptoms. One of these causes may be chronic gastritis of the atrophic type, which means that the stomach wall does not work well and if it is not detected in time it can turn into stomach cancer.

Many people feel these symptoms, but not everyone has endoscopy to look at the stomach wall. This study wants to see if problems in stomach tissue can be identified from a blood sample when an endoscopy cannot be done.

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Commitments

Un artículo publicado en revista indexada
StatusActive
Effective start/end date4/1/193/31/21

Main Funding Source

  • Internal