Project Details
Description
General objective
To evaluate the potential effect of hypoxia on the radiosensitizing capacity of gadolinium-doped carbon dots in in vitro models of cell lines U87, HT29 and primary cultures of cells from glial tumors.
Specific objectives
• Establish the concentration range of the isolated and gadolinium-doped carbon spots that ensures cell viability when subjecting the in vitro models of cell lines U87, HT29 and primary cultures of cells from glial tumors to hypoxia.
• To quantify the change in cell survival generated by exposure to a dose of 6 Grays of ionizing radiation through a medical linear accelerator with the use of isolated carbon doped and gadolinium doped, in tumor tissues under hypoxic conditions.
• Establish the DNA damage generated by exposure to a dose of 6 Grays of ionizing radiation with the use of isolated carbon nanoparticles doped with gadolinium, in tumor tissues under normoxia and hypoxia conditions.
To evaluate the potential effect of hypoxia on the radiosensitizing capacity of gadolinium-doped carbon dots in in vitro models of cell lines U87, HT29 and primary cultures of cells from glial tumors.
Specific objectives
• Establish the concentration range of the isolated and gadolinium-doped carbon spots that ensures cell viability when subjecting the in vitro models of cell lines U87, HT29 and primary cultures of cells from glial tumors to hypoxia.
• To quantify the change in cell survival generated by exposure to a dose of 6 Grays of ionizing radiation through a medical linear accelerator with the use of isolated carbon doped and gadolinium doped, in tumor tissues under hypoxic conditions.
• Establish the DNA damage generated by exposure to a dose of 6 Grays of ionizing radiation with the use of isolated carbon nanoparticles doped with gadolinium, in tumor tissues under normoxia and hypoxia conditions.
| Status | Active |
|---|---|
| Effective start/end date | 1/15/24 → 1/15/25 |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Main Funding Source
- Competitive Funds
Location
- Bogotá D.C.
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