Project Details
Description
"Cancer originates in cellular dysfunction, due to the accumulation of mutations, which change the gene expression profile, and direct the transformation of the cell towards a proliferative option.
The events and molecules that participate can be biomarkers of the presence of the disease, such is the case of the overexpression of mammoglobin in breast cancer.
This type of cancer in women is the leading cause of death from cancer in the world and in Colombia.
Therefore, evaluating the impact of the different levels of mammoglobin expression in breast tumors could have a clinical application, if some relationship is established with the deregulation of the expression of miRNAs, which have been shown to be of great relevance. in the diagnosis, prognosis and treatment of many types of cancer.
This project aims to establish whether different levels of mammoglobin expression in breast tumors have an impact on the deregulation of miRNA expression that leads to the generation of a new tumor subclassification.
Formalin-fixed and paraffin-embedded samples from 40 patients will be used for RNA extraction and the expression of mammoglobin will be evaluated by qPCR and that of miRNAs by the Ilumina platform. The results will be analyzed by statistical and bioinformatics tests.
"We hope to obtain a list of genes that encode miRNAs deregulated according to the expression levels of mammoglobin, which could contribute to a new subclassification of breast tumors."
The events and molecules that participate can be biomarkers of the presence of the disease, such is the case of the overexpression of mammoglobin in breast cancer.
This type of cancer in women is the leading cause of death from cancer in the world and in Colombia.
Therefore, evaluating the impact of the different levels of mammoglobin expression in breast tumors could have a clinical application, if some relationship is established with the deregulation of the expression of miRNAs, which have been shown to be of great relevance. in the diagnosis, prognosis and treatment of many types of cancer.
This project aims to establish whether different levels of mammoglobin expression in breast tumors have an impact on the deregulation of miRNA expression that leads to the generation of a new tumor subclassification.
Formalin-fixed and paraffin-embedded samples from 40 patients will be used for RNA extraction and the expression of mammoglobin will be evaluated by qPCR and that of miRNAs by the Ilumina platform. The results will be analyzed by statistical and bioinformatics tests.
"We hope to obtain a list of genes that encode miRNAs deregulated according to the expression levels of mammoglobin, which could contribute to a new subclassification of breast tumors."
| Status | Finished |
|---|---|
| Effective start/end date | 9/1/21 → 9/30/23 |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Main Funding Source
- National
Location
- Bogotá D.C.
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