The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis

Jose Francisco Meneses-Echavez, Emilio Gonzalez Jimenez, Jacqueline Schmidt Rio-Valle, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Robinson Ramirez-Velez

Resultado de la investigación: Contribución a RevistaArtículo

13 Citas (Scopus)

Resumen

Background: Insulin-like growth factors (IGF's) play a crucial role in\ncontrolling cancer cell proliferation, differentiation and apoptosis.\nExercise has been postulated as an effective intervention in improving\ncancer-related outcomes and survival, although its effects on IGF's are\nnot well understood. This meta-analysis aimed to determine the effects\nof exercise in modulating IGF's system in breast cancer survivors.\nMethods: Databases of PuMed, EMBASE, Cochrane Central Register of\nControlled Trials, EMBASE, ClinicalTrials. gov, SPORTDiscus, LILACS and\nScopus were systematically searched up to November 2014. Effect\nestimates were calculated through a random-effects model of\nmeta-analysis according to the DerSimonian and Laird method.\nHeterogeneity was evaluated with the I-2 test. Risk of bias and\nmethodological quality were evaluated using the PEDro score.\nResults: Five randomized controlled trials (n = 235) were included. Most\nwomen were post-menopausal. High-quality and low risk of bias were found\n(mean PEDro score = 6.2 +/- 1). Exercise resulted in significant\nimprovements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin\nresistance (P <0.05). Non-significant differences were found for\nGlucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No\nevidence of publication bias was detected by Egger's test (p = 0.12).\nConclusions: Exercise improved IGF's in breast cancer survivors. These\nfindings provide novel insight regarding the molecular effects of\nexercise on tumoral microenvironment, apoptosis and survival in breast\ncancer survivors.
Idioma originalEnglish (US)
Páginas (desde-hasta)682-682
Número de páginas1
PublicaciónBMC Cancer
Volumen16
DOI
EstadoPublished - ago 25 2016

Huella dactilar

Somatomedins
Meta-Analysis
Breast Neoplasms
Insulin-Like Growth Factor Binding Protein 3
Insulin
Insulin-Like Growth Factor I
Apoptosis
Publication Bias
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor II
Cell Differentiation
Breast
Randomized Controlled Trials
Cell Proliferation
Databases
Exercise
Neoplasms

Citar esto

Francisco Meneses-Echavez, J., Gonzalez Jimenez, E., Schmidt Rio-Valle, J., Enrique Correa-Bautista, J., Izquierdo, M., & Ramirez-Velez, R. (2016). The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis. BMC Cancer, 16, 682-682. https://doi.org/10.1186/s12885-016-2733-z
Francisco Meneses-Echavez, Jose ; Gonzalez Jimenez, Emilio ; Schmidt Rio-Valle, Jacqueline ; Enrique Correa-Bautista, Jorge ; Izquierdo, Mikel ; Ramirez-Velez, Robinson. / The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis. En: BMC Cancer. 2016 ; Vol. 16. pp. 682-682.
@article{986243d3949e4e1facfd27719aa71ab8,
title = "The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis",
abstract = "Background: Insulin-like growth factors (IGF's) play a crucial role in\ncontrolling cancer cell proliferation, differentiation and apoptosis.\nExercise has been postulated as an effective intervention in improving\ncancer-related outcomes and survival, although its effects on IGF's are\nnot well understood. This meta-analysis aimed to determine the effects\nof exercise in modulating IGF's system in breast cancer survivors.\nMethods: Databases of PuMed, EMBASE, Cochrane Central Register of\nControlled Trials, EMBASE, ClinicalTrials. gov, SPORTDiscus, LILACS and\nScopus were systematically searched up to November 2014. Effect\nestimates were calculated through a random-effects model of\nmeta-analysis according to the DerSimonian and Laird method.\nHeterogeneity was evaluated with the I-2 test. Risk of bias and\nmethodological quality were evaluated using the PEDro score.\nResults: Five randomized controlled trials (n = 235) were included. Most\nwomen were post-menopausal. High-quality and low risk of bias were found\n(mean PEDro score = 6.2 +/- 1). Exercise resulted in significant\nimprovements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin\nresistance (P <0.05). Non-significant differences were found for\nGlucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No\nevidence of publication bias was detected by Egger's test (p = 0.12).\nConclusions: Exercise improved IGF's in breast cancer survivors. These\nfindings provide novel insight regarding the molecular effects of\nexercise on tumoral microenvironment, apoptosis and survival in breast\ncancer survivors.",
author = "{Francisco Meneses-Echavez}, Jose and {Gonzalez Jimenez}, Emilio and {Schmidt Rio-Valle}, Jacqueline and {Enrique Correa-Bautista}, Jorge and Mikel Izquierdo and Robinson Ramirez-Velez",
year = "2016",
month = "8",
day = "25",
doi = "10.1186/s12885-016-2733-z",
language = "English (US)",
volume = "16",
pages = "682--682",
journal = "BMC Cancer",
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Francisco Meneses-Echavez, J, Gonzalez Jimenez, E, Schmidt Rio-Valle, J, Enrique Correa-Bautista, J, Izquierdo, M & Ramirez-Velez, R 2016, 'The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis', BMC Cancer, vol. 16, pp. 682-682. https://doi.org/10.1186/s12885-016-2733-z

The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis. / Francisco Meneses-Echavez, Jose; Gonzalez Jimenez, Emilio; Schmidt Rio-Valle, Jacqueline; Enrique Correa-Bautista, Jorge; Izquierdo, Mikel; Ramirez-Velez, Robinson.

En: BMC Cancer, Vol. 16, 25.08.2016, p. 682-682.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis

AU - Francisco Meneses-Echavez, Jose

AU - Gonzalez Jimenez, Emilio

AU - Schmidt Rio-Valle, Jacqueline

AU - Enrique Correa-Bautista, Jorge

AU - Izquierdo, Mikel

AU - Ramirez-Velez, Robinson

PY - 2016/8/25

Y1 - 2016/8/25

N2 - Background: Insulin-like growth factors (IGF's) play a crucial role in\ncontrolling cancer cell proliferation, differentiation and apoptosis.\nExercise has been postulated as an effective intervention in improving\ncancer-related outcomes and survival, although its effects on IGF's are\nnot well understood. This meta-analysis aimed to determine the effects\nof exercise in modulating IGF's system in breast cancer survivors.\nMethods: Databases of PuMed, EMBASE, Cochrane Central Register of\nControlled Trials, EMBASE, ClinicalTrials. gov, SPORTDiscus, LILACS and\nScopus were systematically searched up to November 2014. Effect\nestimates were calculated through a random-effects model of\nmeta-analysis according to the DerSimonian and Laird method.\nHeterogeneity was evaluated with the I-2 test. Risk of bias and\nmethodological quality were evaluated using the PEDro score.\nResults: Five randomized controlled trials (n = 235) were included. Most\nwomen were post-menopausal. High-quality and low risk of bias were found\n(mean PEDro score = 6.2 +/- 1). Exercise resulted in significant\nimprovements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin\nresistance (P <0.05). Non-significant differences were found for\nGlucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No\nevidence of publication bias was detected by Egger's test (p = 0.12).\nConclusions: Exercise improved IGF's in breast cancer survivors. These\nfindings provide novel insight regarding the molecular effects of\nexercise on tumoral microenvironment, apoptosis and survival in breast\ncancer survivors.

AB - Background: Insulin-like growth factors (IGF's) play a crucial role in\ncontrolling cancer cell proliferation, differentiation and apoptosis.\nExercise has been postulated as an effective intervention in improving\ncancer-related outcomes and survival, although its effects on IGF's are\nnot well understood. This meta-analysis aimed to determine the effects\nof exercise in modulating IGF's system in breast cancer survivors.\nMethods: Databases of PuMed, EMBASE, Cochrane Central Register of\nControlled Trials, EMBASE, ClinicalTrials. gov, SPORTDiscus, LILACS and\nScopus were systematically searched up to November 2014. Effect\nestimates were calculated through a random-effects model of\nmeta-analysis according to the DerSimonian and Laird method.\nHeterogeneity was evaluated with the I-2 test. Risk of bias and\nmethodological quality were evaluated using the PEDro score.\nResults: Five randomized controlled trials (n = 235) were included. Most\nwomen were post-menopausal. High-quality and low risk of bias were found\n(mean PEDro score = 6.2 +/- 1). Exercise resulted in significant\nimprovements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin\nresistance (P <0.05). Non-significant differences were found for\nGlucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No\nevidence of publication bias was detected by Egger's test (p = 0.12).\nConclusions: Exercise improved IGF's in breast cancer survivors. These\nfindings provide novel insight regarding the molecular effects of\nexercise on tumoral microenvironment, apoptosis and survival in breast\ncancer survivors.

U2 - 10.1186/s12885-016-2733-z

DO - 10.1186/s12885-016-2733-z

M3 - Article

C2 - 27562357

VL - 16

SP - 682

EP - 682

JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

ER -

Francisco Meneses-Echavez J, Gonzalez Jimenez E, Schmidt Rio-Valle J, Enrique Correa-Bautista J, Izquierdo M, Ramirez-Velez R. The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis. BMC Cancer. 2016 ago 25;16:682-682. https://doi.org/10.1186/s12885-016-2733-z