Tamoxifen resistance: Emerging molecular targets

Milena Rondón-Lagos, Victoria E. Villegas, Nelson Rangel, Magda Carolina Sánchez, Peter G. Zaphiropoulos

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

57 Citas (Scopus)

Resumen

17β-Estradiol (E2) plays a pivotal role in the development and progression of breast cancer. As a result, blockade of the E2 signal through either tamoxifen (TAM) or aromatase inhibitors is an important therapeutic strategy to treat or prevent estrogen receptor (ER) positive breast cancer. However, resistance to TAM is the major obstacle in endocrine therapy. This resistance occurs either de novo or is acquired after an initial beneficial response. The underlying mechanisms for TAM resistance are probably multifactorial and remain largely unknown. Considering that breast cancer is a very heterogeneous disease and patients respond differently to treatment, the molecular analysis of TAM’s biological activity could provide the necessary framework to understand the complex effects of this drug in target cells. Moreover, this could explain, at least in part, the development of resistance and indicate an optimal therapeutic option. This review highlights the implications of TAM in breast cancer as well as the role of receptors/signal pathways recently suggested to be involved in the development of TAM resistance. G protein—coupled estrogen receptor, Androgen Receptor and Hedgehog signaling pathways are emerging as novel therapeutic targets and prognostic indicators for breast cancer, based on their ability to mediate estrogenic signaling in ERα-positive or-negative breast cancer.

Idioma originalInglés estadounidense
Número de artículo1357
PublicaciónInternational Journal of Molecular Sciences
Volumen17
N.º8
DOI
EstadoPublicada - ago 19 2016

All Science Journal Classification (ASJC) codes

  • Catálisis
  • Biología molecular
  • Espectroscopia
  • Informática aplicada
  • Química física y teórica
  • Química orgánica
  • Química inorgánica

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