Serotonin transporter gene (5-HTT) polymorphism and major depressive disorder in patients in bogotá, Colombia

Isabel Pérez-Olmos, Delia Bustamante, Milcíades Ibáñez-Pinilla

Resultado de la investigación: Contribución a RevistaArtículo

1 Cita (Scopus)

Resumen

Introduction: The 5-HTT short allele has been controversially associated with an increased risk of major depressive disorder. Objective: To determine the association of 5-HTT short allele with major depression in Bogotá, Colombia. Materials and methods: We carried out a study of cases (n=68) matched 1:1 with controls by gender and age (±5 years). Major depression was diagnosed using the Mini-International Neuropsychiatric Interview, and 5-HTT polymorphism using PCR. Results: Females were predominant (82.4%). The S (short) allele predominated in cases compared with controls (S: 72.1% vs. 63.2; L (long): 27.9% vs. 36.8%), and the SL genotype was more frequent in cases (SL: 45.6% vs. 36.8%; LL: 27.9% vs. 36.8%; SS: 26.5% vs. 26.5%), although not significantly. There were significant differences in those under age 37, with a predominance of the S allele in cases (p=0.038; OR=2.75; 95% CI: 0.88-8.64). Multivariate analysis, adjusted for comorbid anxiety disorders, showed a significant association of major depression with the SL genotype (p=0.049; OR=3.20; 95% CI: 1.00-10.23); the S allele was close to statistical significance (p=0.063; OR=2.94; 95% CI: 0.94-9.13), and it was statistically significant in cases under 37 years of age (p=0.026; OR=10.79; 95% CI: 1.32-80.36). Conclusions: The SL genotype was associated with major depressive disorder in patients of all ages. The S allele was significantly associated with major depressive disorder in patients under age 37, adjusted for comorbid anxiety disorders.
Idioma originalEnglish (US)
Páginas (desde-hasta)285-294
Número de páginas10
PublicaciónBiomedica
DOI
EstadoPublished - ene 1 2016

Huella dactilar

Serotonin Plasma Membrane Transport Proteins
Colombia
Major Depressive Disorder
Polymorphism
Genes
Alleles
Genotype
Depression
Anxiety Disorders
Multivariate Analysis
Interviews
Polymerase Chain Reaction

Citar esto

Pérez-Olmos, Isabel ; Bustamante, Delia ; Ibáñez-Pinilla, Milcíades. / Serotonin transporter gene (5-HTT) polymorphism and major depressive disorder in patients in bogotá, Colombia. En: Biomedica. 2016 ; pp. 285-294.
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title = "Serotonin transporter gene (5-HTT) polymorphism and major depressive disorder in patients in bogot{\'a}, Colombia",
abstract = "Introduction: The 5-HTT short allele has been controversially associated with an increased risk of major depressive disorder. Objective: To determine the association of 5-HTT short allele with major depression in Bogot{\'a}, Colombia. Materials and methods: We carried out a study of cases (n=68) matched 1:1 with controls by gender and age (±5 years). Major depression was diagnosed using the Mini-International Neuropsychiatric Interview, and 5-HTT polymorphism using PCR. Results: Females were predominant (82.4{\%}). The S (short) allele predominated in cases compared with controls (S: 72.1{\%} vs. 63.2; L (long): 27.9{\%} vs. 36.8{\%}), and the SL genotype was more frequent in cases (SL: 45.6{\%} vs. 36.8{\%}; LL: 27.9{\%} vs. 36.8{\%}; SS: 26.5{\%} vs. 26.5{\%}), although not significantly. There were significant differences in those under age 37, with a predominance of the S allele in cases (p=0.038; OR=2.75; 95{\%} CI: 0.88-8.64). Multivariate analysis, adjusted for comorbid anxiety disorders, showed a significant association of major depression with the SL genotype (p=0.049; OR=3.20; 95{\%} CI: 1.00-10.23); the S allele was close to statistical significance (p=0.063; OR=2.94; 95{\%} CI: 0.94-9.13), and it was statistically significant in cases under 37 years of age (p=0.026; OR=10.79; 95{\%} CI: 1.32-80.36). Conclusions: The SL genotype was associated with major depressive disorder in patients of all ages. The S allele was significantly associated with major depressive disorder in patients under age 37, adjusted for comorbid anxiety disorders.",
author = "Isabel P{\'e}rez-Olmos and Delia Bustamante and Milc{\'i}ades Ib{\'a}{\~n}ez-Pinilla",
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doi = "10.7705/biomedica.v36i3.3014",
language = "English (US)",
pages = "285--294",
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Serotonin transporter gene (5-HTT) polymorphism and major depressive disorder in patients in bogotá, Colombia. / Pérez-Olmos, Isabel; Bustamante, Delia; Ibáñez-Pinilla, Milcíades.

En: Biomedica, 01.01.2016, p. 285-294.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Serotonin transporter gene (5-HTT) polymorphism and major depressive disorder in patients in bogotá, Colombia

AU - Pérez-Olmos, Isabel

AU - Bustamante, Delia

AU - Ibáñez-Pinilla, Milcíades

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Introduction: The 5-HTT short allele has been controversially associated with an increased risk of major depressive disorder. Objective: To determine the association of 5-HTT short allele with major depression in Bogotá, Colombia. Materials and methods: We carried out a study of cases (n=68) matched 1:1 with controls by gender and age (±5 years). Major depression was diagnosed using the Mini-International Neuropsychiatric Interview, and 5-HTT polymorphism using PCR. Results: Females were predominant (82.4%). The S (short) allele predominated in cases compared with controls (S: 72.1% vs. 63.2; L (long): 27.9% vs. 36.8%), and the SL genotype was more frequent in cases (SL: 45.6% vs. 36.8%; LL: 27.9% vs. 36.8%; SS: 26.5% vs. 26.5%), although not significantly. There were significant differences in those under age 37, with a predominance of the S allele in cases (p=0.038; OR=2.75; 95% CI: 0.88-8.64). Multivariate analysis, adjusted for comorbid anxiety disorders, showed a significant association of major depression with the SL genotype (p=0.049; OR=3.20; 95% CI: 1.00-10.23); the S allele was close to statistical significance (p=0.063; OR=2.94; 95% CI: 0.94-9.13), and it was statistically significant in cases under 37 years of age (p=0.026; OR=10.79; 95% CI: 1.32-80.36). Conclusions: The SL genotype was associated with major depressive disorder in patients of all ages. The S allele was significantly associated with major depressive disorder in patients under age 37, adjusted for comorbid anxiety disorders.

AB - Introduction: The 5-HTT short allele has been controversially associated with an increased risk of major depressive disorder. Objective: To determine the association of 5-HTT short allele with major depression in Bogotá, Colombia. Materials and methods: We carried out a study of cases (n=68) matched 1:1 with controls by gender and age (±5 years). Major depression was diagnosed using the Mini-International Neuropsychiatric Interview, and 5-HTT polymorphism using PCR. Results: Females were predominant (82.4%). The S (short) allele predominated in cases compared with controls (S: 72.1% vs. 63.2; L (long): 27.9% vs. 36.8%), and the SL genotype was more frequent in cases (SL: 45.6% vs. 36.8%; LL: 27.9% vs. 36.8%; SS: 26.5% vs. 26.5%), although not significantly. There were significant differences in those under age 37, with a predominance of the S allele in cases (p=0.038; OR=2.75; 95% CI: 0.88-8.64). Multivariate analysis, adjusted for comorbid anxiety disorders, showed a significant association of major depression with the SL genotype (p=0.049; OR=3.20; 95% CI: 1.00-10.23); the S allele was close to statistical significance (p=0.063; OR=2.94; 95% CI: 0.94-9.13), and it was statistically significant in cases under 37 years of age (p=0.026; OR=10.79; 95% CI: 1.32-80.36). Conclusions: The SL genotype was associated with major depressive disorder in patients of all ages. The S allele was significantly associated with major depressive disorder in patients under age 37, adjusted for comorbid anxiety disorders.

U2 - 10.7705/biomedica.v36i3.3014

DO - 10.7705/biomedica.v36i3.3014

M3 - Article

SP - 285

EP - 294

JO - Biomedica

JF - Biomedica

SN - 0120-4157

ER -