Selective sweeps on novel and introgressed variation shape mimicry loci in a butterfly adaptive radiation

Markus Moest; Steven M. Van Belleghem; Jennifer E. James; Camilo Salazar; Simon H. Martin; Sarah L. Barker; Gilson R.P. Moreira; Claire Merot; Mathieu Joron; Nicola J. Nadeau; Florian M. Steiner; Chris D. Jiggins

doi:10.1371/journal.pbio.3000597

Selective sweeps on novel and introgressed variation shape mimicry loci in a butterfly adaptive radiation

Título traducido de la contribución: Barridos selectivos en nuevos loci introgresados moldean la variación de los genes del mimetismo en una radiación adaptative de mariposas

Markus Moest, Steven M. Van Belleghem, Jennifer E. James, Camilo Salazar, Simon H. Martin, Sarah L. Barker, Gilson R.P. Moreira, Claire Merot, Mathieu Joron, Nicola J. Nadeau, Florian M. Steiner, Chris D. Jiggins

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40 Citas (Scopus)

Resumen

La selección natural deja firmas distintivas en el genoma que pueden revelar regiones blanco y la historia de la evolución adaptativa. Al analizar los datos de la secuencia del genoma de alta cobertura de 4 loci principales de patrones de color muestreados de casi 600 individuos en 53 poblaciones, mostramos una selección generalizada en los patrones de las alas en la radiación adaptativa de Heliconius. Las firmas más fuertes corresponden a loci con los mayores efectos fenotípicos, consistentes con la selección visual por parte de los depredadores, y se encuentran en patrones de color con distribuciones geográficamente restringidas. Estos barridos recientes son similares entre los co-mímicos e indican eventos de cambio de patrones de color a pesar de la fuerte selección estabilizadora. Utilizando simulaciones, comparamos las firmas de barrido esperadas en los barridos duros clásicos con las resultantes de la introgresión adaptativa, un aspecto importante de la evolución del mimetismo en las mariposas Heliconius. Las poblaciones receptoras simuladas muestran un patrón de "volcán" distintivo con picos de aumento de la diversidad genética alrededor de la región seleccionada, característico de los barridos de variación introgresada y consistente con los patrones de diversidad encontrados en algunas poblaciones. Nuestros datos genómicos revelan una historia sorprendentemente dinámica de selección de patrones de color y coevolución en esta radiación adaptativa.

Título traducido de la contribución	Barridos selectivos en nuevos loci introgresados moldean la variación de los genes del mimetismo en una radiación adaptative de mariposas
Idioma original	Inglés estadounidense
Número de artículo	e3000597
Número de páginas	37
Publicación	PLoS Biology
Volumen	18
N.º	2
DOI	https://doi.org/10.1371/journal.pbio.3000597
Estado	Publicada - feb. 6 2020

Áreas temáticas de ASJC Scopus

Neurociencias General
Bioquímica, Genética y Biología Molecular General
Inmunología y Microbiología General
Ciencias Agrícolas y Biológicas General

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Moest, M., Van Belleghem, S. M., James, J. E., Salazar, C., Martin, S. H., Barker, S. L., Moreira, G. R. P., Merot, C., Joron, M., Nadeau, N. J., Steiner, F. M., & Jiggins, C. D. (2020). Selective sweeps on novel and introgressed variation shape mimicry loci in a butterfly adaptive radiation. PLoS Biology, 18(2), Artículo e3000597. https://doi.org/10.1371/journal.pbio.3000597

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abstract = "Natural selection leaves distinct signatures in the genome that can reveal the targets and history of adaptive evolution. By analysing high-coverage genome sequence data from 4 major colour pattern loci sampled from nearly 600 individuals in 53 populations, we show pervasive selection on wing patterns in the Heliconius adaptive radiation. The strongest signatures correspond to loci with the greatest phenotypic effects, consistent with visual selection by predators, and are found in colour patterns with geographically restricted distributions. These recent sweeps are similar between co-mimics and indicate colour pattern turn-over events despite strong stabilising selection. Using simulations, we compare sweep signatures expected under classic hard sweeps with those resulting from adaptive introgression, an important aspect of mimicry evolution in Heliconius butterflies. Simulated recipient populations show a distinct 'volcano' pattern with peaks of increased genetic diversity around the selected target, characteristic of sweeps of introgressed variation and consistent with diversity patterns found in some populations. Our genomic data reveal a surprisingly dynamic history of colour pattern selection and co-evolution in this adaptive radiation.",

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AU - Martin, Simon H.

AU - Barker, Sarah L.

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AU - Merot, Claire

AU - Joron, Mathieu

AU - Nadeau, Nicola J.

AU - Steiner, Florian M.

AU - Jiggins, Chris D.

N1 - Publisher Copyright: © 2020 Moest et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2020/2/6

Y1 - 2020/2/6

N2 - Natural selection leaves distinct signatures in the genome that can reveal the targets and history of adaptive evolution. By analysing high-coverage genome sequence data from 4 major colour pattern loci sampled from nearly 600 individuals in 53 populations, we show pervasive selection on wing patterns in the Heliconius adaptive radiation. The strongest signatures correspond to loci with the greatest phenotypic effects, consistent with visual selection by predators, and are found in colour patterns with geographically restricted distributions. These recent sweeps are similar between co-mimics and indicate colour pattern turn-over events despite strong stabilising selection. Using simulations, we compare sweep signatures expected under classic hard sweeps with those resulting from adaptive introgression, an important aspect of mimicry evolution in Heliconius butterflies. Simulated recipient populations show a distinct 'volcano' pattern with peaks of increased genetic diversity around the selected target, characteristic of sweeps of introgressed variation and consistent with diversity patterns found in some populations. Our genomic data reveal a surprisingly dynamic history of colour pattern selection and co-evolution in this adaptive radiation.

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Selective sweeps on novel and introgressed variation shape mimicry loci in a butterfly adaptive radiation

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