Role of disruptions in O RhD negative donations in Colombia on increasing maternal mortality ratio from haemorrhage

María Isabel Bermúdez-Forero; Diana Carolina Delgado-López; Diego Alexander Anzola-Samudio; Fernando Palomino; Michel Andres Garcia-Otalora

doi:10.1111/tme.13021

Role of disruptions in O RhD negative donations in Colombia on increasing maternal mortality ratio from haemorrhage

Título traducido de la contribución: Papel de las alteraciones en las donaciones O RhD negativo en Colombia en el aumento de la tasa de mortalidad materna por hemorragia

María Isabel Bermúdez-Forero, Diana Carolina Delgado-López, Diego Alexander Anzola-Samudio, Fernando Palomino, Michel Andres Garcia-Otalora

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

Objetivo: El objetivo de este trabajo fue evaluar la relación de la tasa de mortalidad materna por hemorragia obstétrica (MMROH) con las donaciones nacionales de sangre, en particular de sangre O RhD negativo (Oneg) antes y durante la pandemia de COVID-19.

Antecedentes: La razón de mortalidad materna está aumentando en Colombia, sin embargo, poco se sabe de la relación entre las donaciones de sangre y la mortalidad materna por hemorragia obstétrica.

Materiales y métodos: Se realizó un estudio transversal retrospectivo entre el 1 de enero de 2018 y el 31 de diciembre de 2021, para evaluar la MMROH comparada con las donaciones de sangre notificadas al Sistema Nacional de Hemovigilancia de Colombia, a través de métodos no paramétricos. Debido a que se identificó una relación entre donaciones de sangre y MMROH, se amplió el análisis desde 2009 hasta 2017.

Resultados: En 2020, Colombia aumentó el MMROH en un 32% en comparación con 2019, que coincidió con el período de bloqueo para contener el COVID-19. Se identificó una relación inversa (SumD2 = 631,0; rs = -0,7335; p 0,01) entre las donaciones de sangre, particularmente la Oneg (SumD2 = 652,0; rs = -0,7912; p 0,002) y la MMROH. Para los años 2015-2019 y 2021, la media anual de MMROH fue de 8,5 ± 0,5 por 100 000 nacidos vivos cuando la media anual de donaciones de sangre fue de 18,2 ± 0,4 donaciones por 1000 personas y la Oneg fue de 1,0 ± 0,0 donaciones por 1000 personas. Por el contrario, los años 2009-2014 y 2020 mostraron una MMROH anual de 12,6 ± 0,8, cuando la extracción anual de sangre fue de 16,4 ± 0,8 donaciones y la Oneg de 0,9 ± 0,0, p < 0,001.

Conclusiones: Hubo una relación inversa entre la donación de sangre, principalmente la Oneg, y la mortalidad materna por hemorragia obstétrica. Sin embargo, reconocemos que estas muertes podrían estar relacionadas con otros motivos, especialmente cuando se produjeron en zonas rurales con acceso limitado a los servicios médicos.

Título traducido de la contribución	Papel de las alteraciones en las donaciones O RhD negativo en Colombia en el aumento de la tasa de mortalidad materna por hemorragia
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	142-153
Número de páginas	12
Publicación	Transfusion Medicine
Volumen	34
N.º	2
DOI	https://doi.org/10.1111/tme.13021
Estado	Publicada - dic. 27 2023

Áreas temáticas de ASJC Scopus

Hematología

ODS de las Naciones Unidas

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@article{b24e759742c74657b4b5f6c61954699b,

title = "Role of disruptions in O RhD negative donations in Colombia on increasing maternal mortality ratio from haemorrhage",

abstract = "Objective: The aim of this work was to evaluate the relationship of the maternal mortality ratio due to obstetric haemorrhage (MMROH) with the national blood donations, particularly O RhD negative (Oneg) before and during COVID-19 pandemic. Background: The maternal mortality ratio is increasing in Colombia, yet little is known regarding the relationship between blood donations and maternal mortality due to obstetric haemorrhage. Materials and Methods: A retrospective cross-sectional study between January 1, 2018, and December 31, 2021, was performed, to assess MMROH compared to the blood donations notified to the Colombian National Haemovigilance System, through non-parametric methods. Because a relationship between blood donations and MMROH was identified, the analysis was expanded from 2009 to 2017. Results: In 2020, Colombia increased the MMROH by 32% compared to 2019 which coincided with the lockdown period to contain COVID-19. An inversed relationship (SumD2 = 631.0; rs = −0.7335; p 0.01) between blood donations, particularly Oneg (SumD2 = 652.0; rs = −0.7912; p 0.002) and MMROH was identified. For the years 2015–2019 and 2021, the annual mean MMROH was 8.5 ± 0.5 per 100 000 live births when the annual mean blood donations was 18.2 ± 0.4 donations per 1000 people and the Oneg was 1.0 ± 0.0 donations per 1000 people. In contrast, the years 2009–2014 and 2020 displayed an annual MMROH of 12.6 ± 0.8, when the annual collection of blood was 16.4 ± 0.8 donations and the Oneg was 0.9 ± 0.0, p < 0.001. Conclusion: There was an inverse relationship between blood donation, mainly Oneg, and maternal mortality from obstetric haemorrhage. However, we recognise these deaths could be related to other reasons, especially when they occurred in rural areas with limited access to medical services.",

author = "Berm{\'u}dez-Forero, {Mar{\'i}a Isabel} and Delgado-L{\'o}pez, {Diana Carolina} and Anzola-Samudio, {Diego Alexander} and Fernando Palomino and Garcia-Otalora, {Michel Andres}",

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year = "2023",

month = dec,

day = "27",

doi = "10.1111/tme.13021",

language = "English (US)",

volume = "34",

pages = "142--153",

journal = "Transfusion Medicine",

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Role of disruptions in O RhD negative donations in Colombia on increasing maternal mortality ratio from haemorrhage. / Bermúdez-Forero, María Isabel; Delgado-López, Diana Carolina; Anzola-Samudio, Diego Alexander et al.
En: Transfusion Medicine, Vol. 34, N.º 2, 27.12.2023, p. 142-153.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Role of disruptions in O RhD negative donations in Colombia on increasing maternal mortality ratio from haemorrhage

AU - Bermúdez-Forero, María Isabel

AU - Delgado-López, Diana Carolina

AU - Anzola-Samudio, Diego Alexander

AU - Palomino, Fernando

AU - Garcia-Otalora, Michel Andres

PY - 2023/12/27

Y1 - 2023/12/27

N2 - Objective: The aim of this work was to evaluate the relationship of the maternal mortality ratio due to obstetric haemorrhage (MMROH) with the national blood donations, particularly O RhD negative (Oneg) before and during COVID-19 pandemic. Background: The maternal mortality ratio is increasing in Colombia, yet little is known regarding the relationship between blood donations and maternal mortality due to obstetric haemorrhage. Materials and Methods: A retrospective cross-sectional study between January 1, 2018, and December 31, 2021, was performed, to assess MMROH compared to the blood donations notified to the Colombian National Haemovigilance System, through non-parametric methods. Because a relationship between blood donations and MMROH was identified, the analysis was expanded from 2009 to 2017. Results: In 2020, Colombia increased the MMROH by 32% compared to 2019 which coincided with the lockdown period to contain COVID-19. An inversed relationship (SumD2 = 631.0; rs = −0.7335; p 0.01) between blood donations, particularly Oneg (SumD2 = 652.0; rs = −0.7912; p 0.002) and MMROH was identified. For the years 2015–2019 and 2021, the annual mean MMROH was 8.5 ± 0.5 per 100 000 live births when the annual mean blood donations was 18.2 ± 0.4 donations per 1000 people and the Oneg was 1.0 ± 0.0 donations per 1000 people. In contrast, the years 2009–2014 and 2020 displayed an annual MMROH of 12.6 ± 0.8, when the annual collection of blood was 16.4 ± 0.8 donations and the Oneg was 0.9 ± 0.0, p < 0.001. Conclusion: There was an inverse relationship between blood donation, mainly Oneg, and maternal mortality from obstetric haemorrhage. However, we recognise these deaths could be related to other reasons, especially when they occurred in rural areas with limited access to medical services.

AB - Objective: The aim of this work was to evaluate the relationship of the maternal mortality ratio due to obstetric haemorrhage (MMROH) with the national blood donations, particularly O RhD negative (Oneg) before and during COVID-19 pandemic. Background: The maternal mortality ratio is increasing in Colombia, yet little is known regarding the relationship between blood donations and maternal mortality due to obstetric haemorrhage. Materials and Methods: A retrospective cross-sectional study between January 1, 2018, and December 31, 2021, was performed, to assess MMROH compared to the blood donations notified to the Colombian National Haemovigilance System, through non-parametric methods. Because a relationship between blood donations and MMROH was identified, the analysis was expanded from 2009 to 2017. Results: In 2020, Colombia increased the MMROH by 32% compared to 2019 which coincided with the lockdown period to contain COVID-19. An inversed relationship (SumD2 = 631.0; rs = −0.7335; p 0.01) between blood donations, particularly Oneg (SumD2 = 652.0; rs = −0.7912; p 0.002) and MMROH was identified. For the years 2015–2019 and 2021, the annual mean MMROH was 8.5 ± 0.5 per 100 000 live births when the annual mean blood donations was 18.2 ± 0.4 donations per 1000 people and the Oneg was 1.0 ± 0.0 donations per 1000 people. In contrast, the years 2009–2014 and 2020 displayed an annual MMROH of 12.6 ± 0.8, when the annual collection of blood was 16.4 ± 0.8 donations and the Oneg was 0.9 ± 0.0, p < 0.001. Conclusion: There was an inverse relationship between blood donation, mainly Oneg, and maternal mortality from obstetric haemorrhage. However, we recognise these deaths could be related to other reasons, especially when they occurred in rural areas with limited access to medical services.

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Role of disruptions in O RhD negative donations in Colombia on increasing maternal mortality ratio from haemorrhage

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