RNA-seq in kinetoplastids: A powerful tool for the understanding of the biology and host-pathogen interactions

Luz Helena Patino, Juan David Ramírez

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

23 Citas (Scopus)

Resumen

The kinetoplastids include a large number of parasites responsible for serious diseases in humans and animals (Leishmania and Trypanosoma brucei) considered endemic in several regions of the world. These parasites are characterized by digenetic life cycles that undergo morphological and genetic changes that allow them to adapt to different microenvironments on their vertebrates and invertebrates hosts. Recent advances in ´omics´ technology, specifically transcriptomics have allowed to reveal aspects associated with such molecular changes. So far, different techniques have been used to evaluate the gene expression profile during the various stages of the life cycle of these parasites and during the host-parasite interactions. However, some of them have serious drawbacks that limit the precise study and full understanding of their transcriptomes. Therefore, recently has been implemented the latest technology (RNA-seq), which overcomes the drawbacks of traditional methods. In this review, studies that so far have used RNA-seq are presented and allowed to expand our knowledge regarding the biology of these parasites and their interactions with their hosts.

Idioma originalInglés estadounidense
Páginas (desde-hasta)273-282
Número de páginas10
PublicaciónInfection, Genetics and Evolution
Volumen49
DOI
EstadoPublicada - abr 1 2017

All Science Journal Classification (ASJC) codes

  • Microbiología
  • Ecología, evolución, comportamiento y sistemática
  • Biología molecular
  • Genética
  • Microbiología (médica)
  • Enfermedades infecciosas

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