Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis

Antonio García-Hermoso; Robinson Ramírez-Vélez; Carlos A. Celis-Morales; Jordi Olloquequi; Mikel Izquierdo

doi:10.1016/j.exger.2018.03.002

Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis

Título traducido de la contribución: ¿Puede la actividad física atenuar la asociación negativa entre el tiempo sentado y la función cognitiva entre los adultos mayores? Un análisis de mediación

Antonio García-Hermoso, Robinson Ramírez-Vélez, Carlos A. Celis-Morales, Jordi Olloquequi, Mikel Izquierdo

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22 Citas (Scopus)

Resumen

El propósito de este estudio fue examinar la asociación combinada del tiempo sentado y la actividad física con la función cognitiva y determinar si la actividad física moderada a vigorosa (AMPM) es un mediador de la asociación entre el tiempo sentado y la función cognitiva en una muestra representativa a nivel nacional de adultos mayores de Chile. Se analizaron datos de 989 adultos mayores (≥ años, 61,3% mujeres) de la Encuesta de Salud de Chile 2009-2010. La actividad física y el tiempo sentado se midieron mediante el cuestionario de Actividad Física Global. La función cognitiva se evaluó mediante el examen modificado de los niveles Mini-Mental State Examination. Los niveles de actividad física se clasificaron como "inactivos" (<600 minutos de valor metabólico equivalente por semana) o "activos" (≥ metabolic equivalent value minutes per week). El tiempo de permanencia se clasificó como "sedentario", definido como ≥ h de tiempo de permanencia por día, o "no sedentario", definido como <4 h. Creamos los siguientes grupos (i) no sedentario/activo; (ii) no sedentario/inactivo; (iii) sedentario/activo; y (iv) sedentario/inactivo. La macro de PROCESO de Hayes se utilizó para el análisis de mediación simple. En comparación con el grupo de referencia (individuos clasificados como no sedentarios/activos), los adultos mayores que fueron clasificados como sedentarios/activos tuvieron probabilidades elevadas de deterioro cognitivo (OR = 1,90;[IC del 95%: 1,84 a 3,85]). Sin embargo, el odds-ratio para el deterioro cognitivo aumentó sustancialmente en aquellos clasificados como sedentarios/inactivos (OR = 4,85[IC del 95%: 2,54 a 6,24]) en comparación con el grupo de referencia. Se halló que el MVPA mediaba la relación entre el tiempo sentado y la función cognitiva (Efecto indirecto = -0,070[IC del 95%: -0,012 a -0,004]). CONCLUSIÓN: Los presentes hallazgos sugieren que, ya sea que la actividad física general sea alta o baja, pasar grandes cantidades de tiempo sentado está asociado con mayores probabilidades de deterioro cognitivo y que el MVPA debilita ligeramente la relación entre el tiempo sentado y la función cognitiva.

Título traducido de la contribución	¿Puede la actividad física atenuar la asociación negativa entre el tiempo sentado y la función cognitiva entre los adultos mayores? Un análisis de mediación
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	173-177
Número de páginas	5
Publicación	Experimental Gerontology
Volumen	106
DOI	https://doi.org/10.1016/j.exger.2018.03.002
Estado	Publicada - jun. 1 2018

Áreas temáticas de ASJC Scopus

Bioquímica
Estudio del envejecimiento
Biología molecular
Genética
Endocrinología
Biología celular

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title = "Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis",

abstract = "The purpose of this study was to examine the combined association of sitting time and physical activity with cognitive function and to determine whether moderate-to-vigorous physical activity (MVPA) is a mediator of the association between sitting time and cognitive function in a nationally representative sample of older adults from Chile. Data from 989 older adults (≥65 years old, 61.3% female) from the 2009–2010 Chilean Health Survey were analyzed. Physical activity and sitting time were measured using the Global Physical Activity questionnaire. Cognitive function was assessed using the modified Mini-Mental State levels Examination. Physical activity levels were categorized as “inactive” (<600 metabolic equivalent value minutes per week) or “active” (≥600 metabolic equivalent value minutes per week). Sitting time was categorized as “sedentary”, defined as ≥4 h of reported sitting time per day, or “non-sedentary”, defined as <4 h. We created the following groups (i) non-sedentary/active; (ii) non-sedentary/inactive; (iii) sedentary/active; and (iv) sedentary/inactive. Hayes's PROCESS macro was used for the simple mediation analysis. Compared with the reference group (individuals classified as non-sedentary/active), older adults who were classified as sedentary/active had elevated odds of cognitive impairment (OR = 1.90, [95% CI, 1.84 to 3.85]). However, the odds ratio for cognitive impairment was substantially increased in those classified as sedentary/inactive (OR = 4.85 [95% CI, 2.54 to 6.24]) compared with the reference group. MVPA was found to mediate the relationship between sitting time and cognitive function (Indirect Effect = −0.070 [95% CI, −0.012 to −0.004]). Conclusion: The present findings suggest that, whether overall physical activity is high or low, spending large amounts of time sitting is associated with elevated odds of cognitive impairment and that MVPA slightly weakens the relationship between sitting time and cognitive function.",

author = "Antonio Garc{\'i}a-Hermoso and Robinson Ram{\'i}rez-V{\'e}lez and Celis-Morales, {Carlos A.} and Jordi Olloquequi and Mikel Izquierdo",

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Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis. / García-Hermoso, Antonio; Ramírez-Vélez, Robinson; Celis-Morales, Carlos A. et al.
En: Experimental Gerontology, Vol. 106, 01.06.2018, p. 173-177.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

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T1 - Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis

AU - García-Hermoso, Antonio

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AU - Izquierdo, Mikel

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N2 - The purpose of this study was to examine the combined association of sitting time and physical activity with cognitive function and to determine whether moderate-to-vigorous physical activity (MVPA) is a mediator of the association between sitting time and cognitive function in a nationally representative sample of older adults from Chile. Data from 989 older adults (≥65 years old, 61.3% female) from the 2009–2010 Chilean Health Survey were analyzed. Physical activity and sitting time were measured using the Global Physical Activity questionnaire. Cognitive function was assessed using the modified Mini-Mental State levels Examination. Physical activity levels were categorized as “inactive” (<600 metabolic equivalent value minutes per week) or “active” (≥600 metabolic equivalent value minutes per week). Sitting time was categorized as “sedentary”, defined as ≥4 h of reported sitting time per day, or “non-sedentary”, defined as <4 h. We created the following groups (i) non-sedentary/active; (ii) non-sedentary/inactive; (iii) sedentary/active; and (iv) sedentary/inactive. Hayes's PROCESS macro was used for the simple mediation analysis. Compared with the reference group (individuals classified as non-sedentary/active), older adults who were classified as sedentary/active had elevated odds of cognitive impairment (OR = 1.90, [95% CI, 1.84 to 3.85]). However, the odds ratio for cognitive impairment was substantially increased in those classified as sedentary/inactive (OR = 4.85 [95% CI, 2.54 to 6.24]) compared with the reference group. MVPA was found to mediate the relationship between sitting time and cognitive function (Indirect Effect = −0.070 [95% CI, −0.012 to −0.004]). Conclusion: The present findings suggest that, whether overall physical activity is high or low, spending large amounts of time sitting is associated with elevated odds of cognitive impairment and that MVPA slightly weakens the relationship between sitting time and cognitive function.

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Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis

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