Premature delivery influences the immunological composition of colostrum and transitional and mature human milk

Cristina Castellote, Rosario Casillas, Carolina Ramírez-Santana, Francisco J. Pérez-Cano, Margarida Castell, M. Glòria Moretones, M. Carmen López-Sabater, Àngels Franch

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

178 Citas (Scopus)


Human breast milk is the ideal nutrition for the newborn, and in addition to its nutritional contribution, necessary for infant growth and development, it contains various immune bioactive factors that confer some of the numerous beneficial effects of breastfeeding. The current study analyzed the concentrations of IgA, growth factors such as epidermal growth factor (EGF), TGFβ1, and TGFβ2, cytokines IL-6, IL-8, IL-10, IL-13, and TNFα, and TNF-receptor I (TNF-RI) in colostrum and transitional and mature milk from mothers with mature, premature, and very premature infants. Human milk samples were collected from mothers delivering at term (T), preterm (PT), and very preterm (VPT). Milk from all the mothers was collected at 3 different time points after delivery corresponding to colostrum and transitional and mature milk. After obtaining milk whey, IgA, EGF, TGFβ1, and TGFβ2 were determined by ELISA and IL-6, IL-8, IL-10, IL-13, TNFα and TNF-RI by cytometric bead array immunoassay. The colostrum of the PT group was extremely rich in most of the factors studied, but higher concentrations than in the T group were only found for IL-6 (P = 0.051), TGFβ1, and TGFβ2 (P < 0.05). Conversely, the colostrum of the VPT group had lower concentrations of IgA, IL-8, IL-10, and TNFα than those in the T group (P < 0.05). Results suggest that maternal lactogenic compensatory mechanisms accelerating the development of immature breast-fed preterm infants may take effect only after wk 30 of gestation.

Idioma originalInglés estadounidense
Páginas (desde-hasta)1181-1187
Número de páginas7
PublicaciónJournal of Nutrition
EstadoPublicada - jun. 1 2011
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Medicina (miscelánea)
  • Nutrición y dietética


Profundice en los temas de investigación de 'Premature delivery influences the immunological composition of colostrum and transitional and mature human milk'. En conjunto forman una huella única.

Citar esto