Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion

Ramsés López; John Valbuena; Luis E Rodríguez; Marisol Ocampo; Ricardo Vera; Hernando Curtidor; Alvaro Puentes; Javier García; Luis E Ramirez; Manuel E Patarroyo

doi:10.1016/j.peptides.2006.02.001

Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion

Ramsés López, John Valbuena, Luis E Rodríguez, Marisol Ocampo, Ricardo Vera, Hernando Curtidor, Alvaro Puentes, Javier García, Luis E Ramirez, Manuel E Patarroyo

Escuela de Medicina y Ciencias de la Salud

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

14 Citas (Scopus)

Resumen

This work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in the amino terminal region and 31191 (361EIDSTINNLVQEMIHLFSNNY380) at the carboxy terminal. Their binding to erythrocytes was saturable. HABPs 31191 and 31178 recognized 56 and 26 kDa receptors on erythrocyte membrane and inhibited in vitro Plasmodium falciparum merozoite invasion of erythrocytes by between 27% and 46% at 200 microg ml(-1) concentration, suggesting that these MSP-6 protein peptides play a possible role in the invasion process.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1685-92
Número de páginas	8
Publicación	Peptides
Volumen	27
N.º	7
DOI	https://doi.org/10.1016/j.peptides.2006.02.001
Estado	Publicada - jul. 2006

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10.1016/j.peptides.2006.02.001

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@article{061fe3de6f42485cb4f698efb103d623,

title = "Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion",

abstract = "This work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in the amino terminal region and 31191 (361EIDSTINNLVQEMIHLFSNNY380) at the carboxy terminal. Their binding to erythrocytes was saturable. HABPs 31191 and 31178 recognized 56 and 26 kDa receptors on erythrocyte membrane and inhibited in vitro Plasmodium falciparum merozoite invasion of erythrocytes by between 27% and 46% at 200 microg ml(-1) concentration, suggesting that these MSP-6 protein peptides play a possible role in the invasion process.",

author = "Rams{\'e}s L{\'o}pez and John Valbuena and Rodr{\'i}guez, {Luis E} and Marisol Ocampo and Ricardo Vera and Hernando Curtidor and Alvaro Puentes and Javier Garc{\'i}a and Ramirez, {Luis E} and Patarroyo, {Manuel E}",

year = "2006",

month = jul,

doi = "10.1016/j.peptides.2006.02.001",

language = "English (US)",

volume = "27",

pages = "1685--92",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion

AU - López, Ramsés

AU - Valbuena, John

AU - Rodríguez, Luis E

AU - Ocampo, Marisol

AU - Vera, Ricardo

AU - Curtidor, Hernando

AU - Puentes, Alvaro

AU - García, Javier

AU - Ramirez, Luis E

AU - Patarroyo, Manuel E

PY - 2006/7

Y1 - 2006/7

N2 - This work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in the amino terminal region and 31191 (361EIDSTINNLVQEMIHLFSNNY380) at the carboxy terminal. Their binding to erythrocytes was saturable. HABPs 31191 and 31178 recognized 56 and 26 kDa receptors on erythrocyte membrane and inhibited in vitro Plasmodium falciparum merozoite invasion of erythrocytes by between 27% and 46% at 200 microg ml(-1) concentration, suggesting that these MSP-6 protein peptides play a possible role in the invasion process.

AB - This work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in the amino terminal region and 31191 (361EIDSTINNLVQEMIHLFSNNY380) at the carboxy terminal. Their binding to erythrocytes was saturable. HABPs 31191 and 31178 recognized 56 and 26 kDa receptors on erythrocyte membrane and inhibited in vitro Plasmodium falciparum merozoite invasion of erythrocytes by between 27% and 46% at 200 microg ml(-1) concentration, suggesting that these MSP-6 protein peptides play a possible role in the invasion process.

U2 - 10.1016/j.peptides.2006.02.001

DO - 10.1016/j.peptides.2006.02.001

M3 - Article

C2 - 16713025

SN - 0196-9781

VL - 27

SP - 1685

EP - 1692

JO - Peptides

JF - Peptides

IS - 7

ER -

Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion

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