Methotrexate concentrations in synovial membrane and trabecular and cortical bone in rheumatoid arthritis patients

Christophe Bologna, Leila Edno, Juan‐Manuel ‐M Anaya, Francois Canovas, Marc Vanden Berghe, Christian Jorgensen, Marc Galtier, Bernard Combe, Francoise Bressolle, Jacques Sany

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

47 Citas (Scopus)

Resumen

Objective. To determine methotrexate (MTX) concentrations in the synovial membrane (SM) and cortical and trabecular bone of rheumatoid arthritis (RA) patients. Methods. Ten RA patients (9 women, 1 man; mean ± SD age 49.2 ± 10.6, mean disease duration 13.2 ± 9.9 years) undergoing surgical procedures for rheumatoid articular lesions participated in this study. Mean ± SD MTX treatment duration was 26.4 ± 21.3 months. The day preceding surgery, 10 mg of MTX was administered intramuscularly. During surgery, a mean ± SD of 19.7 ± 2.6 hours after MTX administration, SM, bone fragments, and blood were collected simultaneously. MTX was assayed by fluorescence polarization immunoassay in plasma and tissues. Results. The mean ± SD plasma concentration was 0.0252 ± 0.01 nmoles/ml at the time of tissue sampling. The mean MTX concentration in SM was 0.285 ± 0.159 nmoles/gm. The mean MTX concentrations in trabecular and cortical bone were 0.292 ± 0.164 and 0.286 ± 0.126 nmoles/gm, respectively. Conclusion. After intramuscular administration, high MTX concentrations are found in SM and cortical and trabecular bone of RA patients.

Idioma originalInglés estadounidense
Páginas (desde-hasta)1770-1773
Número de páginas4
PublicaciónArthritis & Rheumatism
Volumen37
N.º12
DOI
EstadoPublicada - dic 1994
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Inmulogía y alergología
  • Reumatología
  • Inmunología
  • Farmacología (médica)

Huella

Profundice en los temas de investigación de 'Methotrexate concentrations in synovial membrane and trabecular and cortical bone in rheumatoid arthritis patients'. En conjunto forman una huella única.

Citar esto