Mapping Retinal Abnormalities in Psychosis: Meta-analytical Evidence for Focal Peripapillary and Macular Reductions

Jairo M. Gonzalez-Diaz; Joaquim Radua; Bernardo Sanchez-Dalmau; Anna Camos-Carreras; Diana C. Zamora; Miquel Bernardo

doi:10.1093/schbul/sbac085

Mapping Retinal Abnormalities in Psychosis: Meta-analytical Evidence for Focal Peripapillary and Macular Reductions

Título traducido de la contribución: Mapeo de anomalías retinianas en la psicosis: evidencia metaanalítica de reducciones focales peripapilares y maculares

Jairo M. Gonzalez-Diaz, Joaquim Radua, Bernardo Sanchez-Dalmau, Anna Camos-Carreras, Diana C. Zamora, Miquel Bernardo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

9 Citas (Scopus)

Resumen

Fondo
Varios estudios han sugerido que la estructura de la retina se ve afectada en los trastornos del espectro de la esquizofrenia (SSD). Nuestro objetivo fue investigar la ubicación y el tamaño de las posibles diferencias entre pacientes y controles sanos (HC) en varias medidas de espesor y volumen en la retina.

Diseño del estudio
Se incluyeron estudios transversales que compararon el espesor de la capa de fibras nerviosas peripapilares de la retina (pRNFL), el volumen macular, el espesor macular (MT), el espesor foveal, las células ganglionares y el espesor de la capa plexiforme interna (GCL+IPL), el volumen de la copa y la relación copa/disco. (C/D) en el ojo derecho y/o izquierdo y/o los cuadrantes pRNFL y MT entre pacientes con SSD y HC. Las bases de datos de búsqueda fueron MEDLINE, Web of Science, PsycINFO, Cochrane Central y medrxiv.org. El riesgo de sesgo se evaluó con la escala de Newcastle-Ottawa. Las diferencias de medias estandarizadas (DME), el análisis de subgrupos y la metarregresión con varias variables se calcularon utilizando el paquete dmetar en R. PROSPERO: CRD42021287873.

Resultados del estudio
Se incluyeron datos de 22 informes (942 pacientes, 742 HC). Encontramos un adelgazamiento de la retina en pRNFL (−0,30; IC del 95 %: −0,46, −0,14), mácula (−0,37; IC del 95 %: −0,61, −0,13) y GCL+IPL (−0,33; IC del 95 %: −0,57, −0,10). El adelgazamiento de la retina fue especialmente pronunciado en los cuadrantes superior e inferior del anillo interno de la mácula. También observamos una disminución del volumen macular (−0,44; IC del 95%: −0,68, −0,20) y un aumento en la relación C/D (0,35; IC del 95%: 0,03, 0,67).

Conclusiones
La evidencia actual demuestra un adelgazamiento de la retina en la SSD, que afecta tanto a las estructuras axonales como a las celulares, especialmente enfocadas en el anillo interno de la mácula.

Título traducido de la contribución	Mapeo de anomalías retinianas en la psicosis: evidencia metaanalítica de reducciones focales peripapilares y maculares
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1194-1205
Número de páginas	12
Publicación	Schizophrenia Bulletin
Volumen	48
N.º	6
DOI	https://doi.org/10.1093/schbul/sbac085
Estado	Publicada - nov. 18 2022

Áreas temáticas de ASJC Scopus

Psiquiatría y salud mental

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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@article{8dd652deda754682a9d8b8568ea36f9b,

title = "Mapping Retinal Abnormalities in Psychosis: Meta-analytical Evidence for Focal Peripapillary and Macular Reductions",

abstract = "BACKGROUND: Several studies have suggested that the retina structure is affected in schizophrenia spectrum disorders (SSD). We aimed to investigate the location and size of the potential differences between patients and healthy controls (HC) in several thickness and volume measures across the retina. STUDY DESIGN: We included cross-sectional studies comparing peripapillary retinal nerve fiber layer (pRNFL) thickness, macular volume, macular thickness (MT), foveal thickness, ganglion cell and inner plexiform layer thickness (GCL+IPL), cup volume, and cup/disc ratio (C/D) in the right and/or left eyes and/or the pRNFL and MT quadrants between patients with SSD and HC. Search databases were MEDLINE, Web of Science, PsycINFO, Cochrane Central, and medrxiv.org. Risk of bias was assessed with the Newcastle-Ottawa Scale. Standardized mean differences (SMD), subgroup analysis, and meta-regression with several variables were computed using the dmetar package in R. PROSPERO: CRD42021287873. STUDY RESULTS: Data from 22 reports (942 patients, 742 HC) were included. We found a retinal thinning in pRNFL (-0.30; 95% CI: -0.46, -0.14), macula (-0.37; 95% CI: -0.61, -0.13), and GCL+IPL (-0.33; 95% CI: -0.57, -0.10). The retinal thinning was especially pronounced in the superior and inferior quadrants of the inner ring of the macula. We also observed a decrease of macular volume (-0.44; 95% CI: -0.68, -0.20) and an increase in C/D ratio (0.35; 95% CI: 0.03, 0.67). CONCLUSIONS: Current evidence demonstrates retinal thinning in SSD, affecting both axonal and cellular structures, specially focused in the inner ring of the macula.",

author = "Gonzalez-Diaz, {Jairo M.} and Joaquim Radua and Bernardo Sanchez-Dalmau and Anna Camos-Carreras and Zamora, {Diana C.} and Miquel Bernardo",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.",

year = "2022",

month = nov,

day = "18",

doi = "10.1093/schbul/sbac085",

language = "English (US)",

volume = "48",

pages = "1194--1205",

journal = "Schizophrenia Bulletin",

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T1 - Mapping Retinal Abnormalities in Psychosis

T2 - Meta-analytical Evidence for Focal Peripapillary and Macular Reductions

AU - Gonzalez-Diaz, Jairo M.

AU - Radua, Joaquim

AU - Sanchez-Dalmau, Bernardo

AU - Camos-Carreras, Anna

AU - Zamora, Diana C.

AU - Bernardo, Miquel

N1 - Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2022/11/18

Y1 - 2022/11/18

N2 - BACKGROUND: Several studies have suggested that the retina structure is affected in schizophrenia spectrum disorders (SSD). We aimed to investigate the location and size of the potential differences between patients and healthy controls (HC) in several thickness and volume measures across the retina. STUDY DESIGN: We included cross-sectional studies comparing peripapillary retinal nerve fiber layer (pRNFL) thickness, macular volume, macular thickness (MT), foveal thickness, ganglion cell and inner plexiform layer thickness (GCL+IPL), cup volume, and cup/disc ratio (C/D) in the right and/or left eyes and/or the pRNFL and MT quadrants between patients with SSD and HC. Search databases were MEDLINE, Web of Science, PsycINFO, Cochrane Central, and medrxiv.org. Risk of bias was assessed with the Newcastle-Ottawa Scale. Standardized mean differences (SMD), subgroup analysis, and meta-regression with several variables were computed using the dmetar package in R. PROSPERO: CRD42021287873. STUDY RESULTS: Data from 22 reports (942 patients, 742 HC) were included. We found a retinal thinning in pRNFL (-0.30; 95% CI: -0.46, -0.14), macula (-0.37; 95% CI: -0.61, -0.13), and GCL+IPL (-0.33; 95% CI: -0.57, -0.10). The retinal thinning was especially pronounced in the superior and inferior quadrants of the inner ring of the macula. We also observed a decrease of macular volume (-0.44; 95% CI: -0.68, -0.20) and an increase in C/D ratio (0.35; 95% CI: 0.03, 0.67). CONCLUSIONS: Current evidence demonstrates retinal thinning in SSD, affecting both axonal and cellular structures, specially focused in the inner ring of the macula.

AB - BACKGROUND: Several studies have suggested that the retina structure is affected in schizophrenia spectrum disorders (SSD). We aimed to investigate the location and size of the potential differences between patients and healthy controls (HC) in several thickness and volume measures across the retina. STUDY DESIGN: We included cross-sectional studies comparing peripapillary retinal nerve fiber layer (pRNFL) thickness, macular volume, macular thickness (MT), foveal thickness, ganglion cell and inner plexiform layer thickness (GCL+IPL), cup volume, and cup/disc ratio (C/D) in the right and/or left eyes and/or the pRNFL and MT quadrants between patients with SSD and HC. Search databases were MEDLINE, Web of Science, PsycINFO, Cochrane Central, and medrxiv.org. Risk of bias was assessed with the Newcastle-Ottawa Scale. Standardized mean differences (SMD), subgroup analysis, and meta-regression with several variables were computed using the dmetar package in R. PROSPERO: CRD42021287873. STUDY RESULTS: Data from 22 reports (942 patients, 742 HC) were included. We found a retinal thinning in pRNFL (-0.30; 95% CI: -0.46, -0.14), macula (-0.37; 95% CI: -0.61, -0.13), and GCL+IPL (-0.33; 95% CI: -0.57, -0.10). The retinal thinning was especially pronounced in the superior and inferior quadrants of the inner ring of the macula. We also observed a decrease of macular volume (-0.44; 95% CI: -0.68, -0.20) and an increase in C/D ratio (0.35; 95% CI: 0.03, 0.67). CONCLUSIONS: Current evidence demonstrates retinal thinning in SSD, affecting both axonal and cellular structures, specially focused in the inner ring of the macula.

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Mapping Retinal Abnormalities in Psychosis: Meta-analytical Evidence for Focal Peripapillary and Macular Reductions

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