TY - JOUR
T1 - Human coding and noncoding DNA
T2 - Compositional correlations
AU - Clay, Oliver
AU - Cacciò, Simone
AU - Zoubak, Serguei
AU - Mouchiroud, Dominique
AU - Bernardi, Giorgio
N1 - Funding Information:
We thank Dr. Giuseppe D'Onofrio for careful reading of the manuscript and for discussions, and Dr. Gabriel Macaya for helpful comments. Simone CaccioÁ and Serguei Zoubak acknowledge the Federation of European Biochemical Societies for the award of a long-term fellowship.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/2
Y1 - 1996/2
N2 - As the correlations between GC levels in third, codon positions (GC3) and intergenic sequence GC levels can be used to assess the distribution of genes in the human genome, they were studied in detail. Previous work from our laboratory has demonstrated the existence of linear correlations between GC levels of exons, introns, third codon positions, 5′ flanking regions of genes, and long genomic DNA sequences (> 10 kb) or DNA molecules (50-100 kb) in which the genes are embedded. The present study confirms and extends the previous results using a larger set of data. Furthermore, an analysis of 4270 human genomic DNA and cDNA sequences has allowed us to confirm a correlation of GC3 against GC1+2. Recent additions to the sequence database have also allowed separate analyses of the 5′ flanking regions of CpG island and non-CpG island genes as well as analyses of 3′ flanking regions, which suggest that the GC levels of 3′ flanking regions are closer to those of intergenic DNA than are those of other regions of genes.
AB - As the correlations between GC levels in third, codon positions (GC3) and intergenic sequence GC levels can be used to assess the distribution of genes in the human genome, they were studied in detail. Previous work from our laboratory has demonstrated the existence of linear correlations between GC levels of exons, introns, third codon positions, 5′ flanking regions of genes, and long genomic DNA sequences (> 10 kb) or DNA molecules (50-100 kb) in which the genes are embedded. The present study confirms and extends the previous results using a larger set of data. Furthermore, an analysis of 4270 human genomic DNA and cDNA sequences has allowed us to confirm a correlation of GC3 against GC1+2. Recent additions to the sequence database have also allowed separate analyses of the 5′ flanking regions of CpG island and non-CpG island genes as well as analyses of 3′ flanking regions, which suggest that the GC levels of 3′ flanking regions are closer to those of intergenic DNA than are those of other regions of genes.
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U2 - 10.1006/mpev.1996.0002
DO - 10.1006/mpev.1996.0002
M3 - Article
C2 - 8673288
AN - SCOPUS:0030077335
SN - 1055-7903
VL - 5
SP - 2
EP - 12
JO - Molecular Phylogenetics and Evolution
JF - Molecular Phylogenetics and Evolution
IS - 1
ER -