Handgrip and knee extension strength as predictors of cancer mortality

A systematic review and meta-analysis

A. García-Hermoso, R. Ramírez-Vélez, M. D. Peterson, F. Lobelo, I. Cavero-Redondo, J. E. Correa-Bautista, V. Martínez-Vizcaíno

Resultado de la investigación: Contribución a RevistaArtículo de revisión

1 Cita (Scopus)

Resumen

The specific role of different strength measures on mortality risk needs to be clarified to gain a better understanding of the clinical importance of different muscle groups, as well as to inform intervention protocols in relation to reducing early mortality. The aim of the systematic review and meta-analysis was to determine the relationship between muscular strength and risk of cancer mortality. Eligible cohort studies were those that examined the association between muscular strength, as assessed using validated tests, and cancer mortality in healthy youth and adults. The hazard ratio (HR) estimates obtained were pooled using random effects meta-analysis models. The outcome was cancer mortality assessed using the HR (Cox proportional hazards model). Eleven prospective studies with 1 309 413 participants were included, and 9787 cancer-specific deaths were reported. Overall, greater handgrip (HR = 0.97, 95% CI, 0.92-1.02; P =.055; I2 = 18.9%) and knee extension strength (HR = 0.98, 95% CI, 0.95-1.00; P =.051; I2 = 60.6%) were barely significant associated with reduced risk of cancer mortality. Our study suggests that higher level of muscular strength is not statistically associated with lower risk of cancer mortality.

Idioma originalEnglish (US)
Páginas (desde-hasta)1852-1858
Número de páginas7
PublicaciónScandinavian Journal of Medicine and Science in Sports
Volumen28
N.º8
DOI
EstadoPublished - ago 1 2018

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Citar esto

García-Hermoso, A., Ramírez-Vélez, R., Peterson, M. D., Lobelo, F., Cavero-Redondo, I., Correa-Bautista, J. E., & Martínez-Vizcaíno, V. (2018). Handgrip and knee extension strength as predictors of cancer mortality: A systematic review and meta-analysis. Scandinavian Journal of Medicine and Science in Sports, 28(8), 1852-1858. https://doi.org/10.1111/sms.13206
García-Hermoso, A. ; Ramírez-Vélez, R. ; Peterson, M. D. ; Lobelo, F. ; Cavero-Redondo, I. ; Correa-Bautista, J. E. ; Martínez-Vizcaíno, V. / Handgrip and knee extension strength as predictors of cancer mortality : A systematic review and meta-analysis. En: Scandinavian Journal of Medicine and Science in Sports. 2018 ; Vol. 28, N.º 8. pp. 1852-1858.
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title = "Handgrip and knee extension strength as predictors of cancer mortality: A systematic review and meta-analysis",
abstract = "The specific role of different strength measures on mortality risk needs to be clarified to gain a better understanding of the clinical importance of different muscle groups, as well as to inform intervention protocols in relation to reducing early mortality. The aim of the systematic review and meta-analysis was to determine the relationship between muscular strength and risk of cancer mortality. Eligible cohort studies were those that examined the association between muscular strength, as assessed using validated tests, and cancer mortality in healthy youth and adults. The hazard ratio (HR) estimates obtained were pooled using random effects meta-analysis models. The outcome was cancer mortality assessed using the HR (Cox proportional hazards model). Eleven prospective studies with 1 309 413 participants were included, and 9787 cancer-specific deaths were reported. Overall, greater handgrip (HR = 0.97, 95{\%} CI, 0.92-1.02; P =.055; I2 = 18.9{\%}) and knee extension strength (HR = 0.98, 95{\%} CI, 0.95-1.00; P =.051; I2 = 60.6{\%}) were barely significant associated with reduced risk of cancer mortality. Our study suggests that higher level of muscular strength is not statistically associated with lower risk of cancer mortality.",
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García-Hermoso, A, Ramírez-Vélez, R, Peterson, MD, Lobelo, F, Cavero-Redondo, I, Correa-Bautista, JE & Martínez-Vizcaíno, V 2018, 'Handgrip and knee extension strength as predictors of cancer mortality: A systematic review and meta-analysis', Scandinavian Journal of Medicine and Science in Sports, vol. 28, n.º 8, pp. 1852-1858. https://doi.org/10.1111/sms.13206

Handgrip and knee extension strength as predictors of cancer mortality : A systematic review and meta-analysis. / García-Hermoso, A.; Ramírez-Vélez, R.; Peterson, M. D.; Lobelo, F.; Cavero-Redondo, I.; Correa-Bautista, J. E.; Martínez-Vizcaíno, V.

En: Scandinavian Journal of Medicine and Science in Sports, Vol. 28, N.º 8, 01.08.2018, p. 1852-1858.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

TY - JOUR

T1 - Handgrip and knee extension strength as predictors of cancer mortality

T2 - A systematic review and meta-analysis

AU - García-Hermoso, A.

AU - Ramírez-Vélez, R.

AU - Peterson, M. D.

AU - Lobelo, F.

AU - Cavero-Redondo, I.

AU - Correa-Bautista, J. E.

AU - Martínez-Vizcaíno, V.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - The specific role of different strength measures on mortality risk needs to be clarified to gain a better understanding of the clinical importance of different muscle groups, as well as to inform intervention protocols in relation to reducing early mortality. The aim of the systematic review and meta-analysis was to determine the relationship between muscular strength and risk of cancer mortality. Eligible cohort studies were those that examined the association between muscular strength, as assessed using validated tests, and cancer mortality in healthy youth and adults. The hazard ratio (HR) estimates obtained were pooled using random effects meta-analysis models. The outcome was cancer mortality assessed using the HR (Cox proportional hazards model). Eleven prospective studies with 1 309 413 participants were included, and 9787 cancer-specific deaths were reported. Overall, greater handgrip (HR = 0.97, 95% CI, 0.92-1.02; P =.055; I2 = 18.9%) and knee extension strength (HR = 0.98, 95% CI, 0.95-1.00; P =.051; I2 = 60.6%) were barely significant associated with reduced risk of cancer mortality. Our study suggests that higher level of muscular strength is not statistically associated with lower risk of cancer mortality.

AB - The specific role of different strength measures on mortality risk needs to be clarified to gain a better understanding of the clinical importance of different muscle groups, as well as to inform intervention protocols in relation to reducing early mortality. The aim of the systematic review and meta-analysis was to determine the relationship between muscular strength and risk of cancer mortality. Eligible cohort studies were those that examined the association between muscular strength, as assessed using validated tests, and cancer mortality in healthy youth and adults. The hazard ratio (HR) estimates obtained were pooled using random effects meta-analysis models. The outcome was cancer mortality assessed using the HR (Cox proportional hazards model). Eleven prospective studies with 1 309 413 participants were included, and 9787 cancer-specific deaths were reported. Overall, greater handgrip (HR = 0.97, 95% CI, 0.92-1.02; P =.055; I2 = 18.9%) and knee extension strength (HR = 0.98, 95% CI, 0.95-1.00; P =.051; I2 = 60.6%) were barely significant associated with reduced risk of cancer mortality. Our study suggests that higher level of muscular strength is not statistically associated with lower risk of cancer mortality.

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U2 - 10.1111/sms.13206

DO - 10.1111/sms.13206

M3 - Review article

VL - 28

SP - 1852

EP - 1858

JO - Scandinavian Journal of Medicine and Science in Sports

JF - Scandinavian Journal of Medicine and Science in Sports

SN - 0905-7188

IS - 8

ER -

García-Hermoso A, Ramírez-Vélez R, Peterson MD, Lobelo F, Cavero-Redondo I, Correa-Bautista JE y otros. Handgrip and knee extension strength as predictors of cancer mortality: A systematic review and meta-analysis. Scandinavian Journal of Medicine and Science in Sports. 2018 ago 1;28(8):1852-1858. https://doi.org/10.1111/sms.13206