Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America

Valentina Caicedo-Garzón, Fabian C. Salgado-Roa, Melissa Sánchez-Herrera, Carolina Hernández, Luisa María Arias-Giraldo, Lineth García, Gustavo Vallejo, Omar Cantillo, Catalina Tovar, Joao Aristeu Da Rosa, Hernán J. Carrasco, Maikell Segovia, Camilo Salazar, Juan David Ramírez

Resultado de la investigación: Contribución a una revistaArtículo

Resumen

Triatomines are the vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Although Triatoma and Rhodnius are the most-studied vector genera, other triatomines, such as Panstrongylus, also transmit T. cruzi, creating new epidemiological scenarios. Panstrongylus has at least 13 reported species but there is limited information about its intraspecific genetic variation and patterns of diversification. Here, we begin to fill this gap by studying populations of P. geniculatus from Colombia and Venezuela and including other epidemiologically important species from the region. We examined the pattern of diversification of P. geniculatus in Colombia using mitochondrial and nuclear ribosomal data. Genetic diversity and differentiation were calculated within and among populations of P. geniculatus. Moreover, we constructed maximum likelihood and Bayesian inference phylogenies and haplotype networks using P. geniculatus and other species from the genus (P. megistus, P. lignarius, P. lutzi, P. tupynambai, P. chinai, P. rufotuberculatus and P. howardi). Using a coalescence framework, we also dated the P. geniculatus lineages. The total evidence tree showed that P. geniculatus is a monophyletic species, with four clades that are concordant with its geographic distribution and are partly explained by the Andes orogeny. However, other factors, including anthropogenic and eco-epidemiological effects must be investigated to explain the existence of recent geographic P. geniculatus lineages. The epidemiological dynamics in structured vector populations, such as those found here, warrant further investigation. Extending our knowledge of P. geniculatus is necessary for the accurate development of effective strategies for the control of Chagas disease vectors.

Idioma originalInglés estadounidense
Número de artículoe0223963
PublicaciónPLoS One
Volumen14
N.º10
DOI
EstadoPublicada - ene 1 2019

All Science Journal Classification (ASJC) codes

  • Bioquímica, genética y biología molecular (todo)
  • Agricultura y biología (todo)
  • General

Citar esto

Caicedo-Garzón, V., Salgado-Roa, F. C., Sánchez-Herrera, M., Hernández, C., Arias-Giraldo, L. M., García, L., ... Ramírez, J. D. (2019). Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America. PLoS One, 14(10), [e0223963]. https://doi.org/10.1371/journal.pone.0223963
Caicedo-Garzón, Valentina ; Salgado-Roa, Fabian C. ; Sánchez-Herrera, Melissa ; Hernández, Carolina ; Arias-Giraldo, Luisa María ; García, Lineth ; Vallejo, Gustavo ; Cantillo, Omar ; Tovar, Catalina ; Da Rosa, Joao Aristeu ; Carrasco, Hernán J. ; Segovia, Maikell ; Salazar, Camilo ; Ramírez, Juan David. / Genetic diversification of Panstrongylus geniculatus (Reduviidae : Triatominae) in northern South America. En: PLoS One. 2019 ; Vol. 14, N.º 10.
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title = "Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America",
abstract = "Triatomines are the vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Although Triatoma and Rhodnius are the most-studied vector genera, other triatomines, such as Panstrongylus, also transmit T. cruzi, creating new epidemiological scenarios. Panstrongylus has at least 13 reported species but there is limited information about its intraspecific genetic variation and patterns of diversification. Here, we begin to fill this gap by studying populations of P. geniculatus from Colombia and Venezuela and including other epidemiologically important species from the region. We examined the pattern of diversification of P. geniculatus in Colombia using mitochondrial and nuclear ribosomal data. Genetic diversity and differentiation were calculated within and among populations of P. geniculatus. Moreover, we constructed maximum likelihood and Bayesian inference phylogenies and haplotype networks using P. geniculatus and other species from the genus (P. megistus, P. lignarius, P. lutzi, P. tupynambai, P. chinai, P. rufotuberculatus and P. howardi). Using a coalescence framework, we also dated the P. geniculatus lineages. The total evidence tree showed that P. geniculatus is a monophyletic species, with four clades that are concordant with its geographic distribution and are partly explained by the Andes orogeny. However, other factors, including anthropogenic and eco-epidemiological effects must be investigated to explain the existence of recent geographic P. geniculatus lineages. The epidemiological dynamics in structured vector populations, such as those found here, warrant further investigation. Extending our knowledge of P. geniculatus is necessary for the accurate development of effective strategies for the control of Chagas disease vectors.",
author = "Valentina Caicedo-Garz{\'o}n and Salgado-Roa, {Fabian C.} and Melissa S{\'a}nchez-Herrera and Carolina Hern{\'a}ndez and Arias-Giraldo, {Luisa Mar{\'i}a} and Lineth Garc{\'i}a and Gustavo Vallejo and Omar Cantillo and Catalina Tovar and {Da Rosa}, {Joao Aristeu} and Carrasco, {Hern{\'a}n J.} and Maikell Segovia and Camilo Salazar and Ram{\'i}rez, {Juan David}",
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Caicedo-Garzón, V, Salgado-Roa, FC, Sánchez-Herrera, M, Hernández, C, Arias-Giraldo, LM, García, L, Vallejo, G, Cantillo, O, Tovar, C, Da Rosa, JA, Carrasco, HJ, Segovia, M, Salazar, C & Ramírez, JD 2019, 'Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America', PLoS One, vol. 14, n.º 10, e0223963. https://doi.org/10.1371/journal.pone.0223963

Genetic diversification of Panstrongylus geniculatus (Reduviidae : Triatominae) in northern South America. / Caicedo-Garzón, Valentina; Salgado-Roa, Fabian C.; Sánchez-Herrera, Melissa; Hernández, Carolina; Arias-Giraldo, Luisa María; García, Lineth; Vallejo, Gustavo; Cantillo, Omar; Tovar, Catalina; Da Rosa, Joao Aristeu; Carrasco, Hernán J.; Segovia, Maikell; Salazar, Camilo; Ramírez, Juan David.

En: PLoS One, Vol. 14, N.º 10, e0223963, 01.01.2019.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Genetic diversification of Panstrongylus geniculatus (Reduviidae

T2 - Triatominae) in northern South America

AU - Caicedo-Garzón, Valentina

AU - Salgado-Roa, Fabian C.

AU - Sánchez-Herrera, Melissa

AU - Hernández, Carolina

AU - Arias-Giraldo, Luisa María

AU - García, Lineth

AU - Vallejo, Gustavo

AU - Cantillo, Omar

AU - Tovar, Catalina

AU - Da Rosa, Joao Aristeu

AU - Carrasco, Hernán J.

AU - Segovia, Maikell

AU - Salazar, Camilo

AU - Ramírez, Juan David

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Triatomines are the vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Although Triatoma and Rhodnius are the most-studied vector genera, other triatomines, such as Panstrongylus, also transmit T. cruzi, creating new epidemiological scenarios. Panstrongylus has at least 13 reported species but there is limited information about its intraspecific genetic variation and patterns of diversification. Here, we begin to fill this gap by studying populations of P. geniculatus from Colombia and Venezuela and including other epidemiologically important species from the region. We examined the pattern of diversification of P. geniculatus in Colombia using mitochondrial and nuclear ribosomal data. Genetic diversity and differentiation were calculated within and among populations of P. geniculatus. Moreover, we constructed maximum likelihood and Bayesian inference phylogenies and haplotype networks using P. geniculatus and other species from the genus (P. megistus, P. lignarius, P. lutzi, P. tupynambai, P. chinai, P. rufotuberculatus and P. howardi). Using a coalescence framework, we also dated the P. geniculatus lineages. The total evidence tree showed that P. geniculatus is a monophyletic species, with four clades that are concordant with its geographic distribution and are partly explained by the Andes orogeny. However, other factors, including anthropogenic and eco-epidemiological effects must be investigated to explain the existence of recent geographic P. geniculatus lineages. The epidemiological dynamics in structured vector populations, such as those found here, warrant further investigation. Extending our knowledge of P. geniculatus is necessary for the accurate development of effective strategies for the control of Chagas disease vectors.

AB - Triatomines are the vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Although Triatoma and Rhodnius are the most-studied vector genera, other triatomines, such as Panstrongylus, also transmit T. cruzi, creating new epidemiological scenarios. Panstrongylus has at least 13 reported species but there is limited information about its intraspecific genetic variation and patterns of diversification. Here, we begin to fill this gap by studying populations of P. geniculatus from Colombia and Venezuela and including other epidemiologically important species from the region. We examined the pattern of diversification of P. geniculatus in Colombia using mitochondrial and nuclear ribosomal data. Genetic diversity and differentiation were calculated within and among populations of P. geniculatus. Moreover, we constructed maximum likelihood and Bayesian inference phylogenies and haplotype networks using P. geniculatus and other species from the genus (P. megistus, P. lignarius, P. lutzi, P. tupynambai, P. chinai, P. rufotuberculatus and P. howardi). Using a coalescence framework, we also dated the P. geniculatus lineages. The total evidence tree showed that P. geniculatus is a monophyletic species, with four clades that are concordant with its geographic distribution and are partly explained by the Andes orogeny. However, other factors, including anthropogenic and eco-epidemiological effects must be investigated to explain the existence of recent geographic P. geniculatus lineages. The epidemiological dynamics in structured vector populations, such as those found here, warrant further investigation. Extending our knowledge of P. geniculatus is necessary for the accurate development of effective strategies for the control of Chagas disease vectors.

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Caicedo-Garzón V, Salgado-Roa FC, Sánchez-Herrera M, Hernández C, Arias-Giraldo LM, García L y otros. Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America. PLoS One. 2019 ene 1;14(10). e0223963. https://doi.org/10.1371/journal.pone.0223963