Epidemiological characterisation of asymptomatic carriers of COVID-19 in Colombia: A cross-sectional study

Aníbal A. Teherán; Gabriel Camero Ramos; Ronald Prado De La Guardia; Carolina Hernández; Giovanny Herrera; Luis M. Pombo; Albert Alejandro Avila; Carolina Flórez; Esther C. Barros; Luis Perez-Garcia; Alberto Paniz-Mondolfi; Juan David Ramírez

doi:10.1136/bmjopen-2020-042122

Epidemiological characterisation of asymptomatic carriers of COVID-19 in Colombia: A cross-sectional study

Título traducido de la contribución: Caracterización epidemiológica de los portadores asintomáticos de COVID-19 en Colombia

Aníbal A. Teherán, Gabriel Camero Ramos, Ronald Prado De La Guardia, Carolina Hernández, Giovanny Herrera, Luis M. Pombo, Albert Alejandro Avila, Carolina Flórez, Esther C. Barros, Luis Perez-Garcia, Alberto Paniz-Mondolfi, Juan David Ramírez

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Resumen

Introducción Los portadores asintomáticos (CA) del nuevo SARS-CoV-2 representan una importante fuente de propagación del COVID-19. El diagnóstico temprano de estos casos es una poderosa herramienta para controlar la pandemia. Nuestro objetivo fue caracterizar a los pacientes con condición de AC e identificar los factores sociodemográficos asociados. Métodos Utilizando un diseño transversal y la base de datos nacional de ocurrencia diaria de COVID-19, caracterizamos social y demográficamente a todos los AC. Se realizó un análisis de correspondencia adicional y un modelo de regresión logística para identificar las características asociadas con el estado de las AC (OR, IC del 95%). Resultados Se identificaron 76.162 CA (12,1%; IC 95%: 12,0% a 12,2%), principalmente antes de la semana epidemiológica 35. La edad≤26 años (1,18; 1,09 a 1,28), el sexo masculino (1,51; 1,40 a 1,62), los casos importados de Venezuela, Argentina, Brasil, Alemania, Puerto Rico, España, EE.UU. o México (12,6; 3,03 a 52,5) y los casos autóctonos (22,6; 5,62 a 91,4) aumentaron el riesgo de identificar CA. También se identificaron grupos de departamentos con una asociación moderada (1,23; 1,13 a 1,34) y fuerte (19,8; 18,6 a 21,0) con los CA. Conclusión Se identificaron características sociodemográficas fuertemente asociadas a los CA, lo que puede explicar su relevancia epidemiológica y su utilidad para optimizar las estrategias de cribado masivo y prevenir la transmisión de persona a persona.

Título traducido de la contribución	Caracterización epidemiológica de los portadores asintomáticos de COVID-19 en Colombia
Idioma original	Inglés estadounidense
Número de artículo	e042122
Publicación	BMJ Open
Volumen	10
N.º	12
DOI	https://doi.org/10.1136/bmjopen-2020-042122
Estado	Publicada - dic. 7 2020

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Medicina General

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Teherán, A. A., Camero Ramos, G., Prado De La Guardia, R., Hernández, C., Herrera, G., Pombo, L. M., Avila, A. A., Flórez, C., Barros, E. C., Perez-Garcia, L., Paniz-Mondolfi, A., & Ramírez, J. D. (2020). Epidemiological characterisation of asymptomatic carriers of COVID-19 in Colombia: A cross-sectional study. BMJ Open, 10(12), Artículo e042122. https://doi.org/10.1136/bmjopen-2020-042122

@article{b2e27cc61f7a473a87676c2bfec4fc42,

title = "Epidemiological characterisation of asymptomatic carriers of COVID-19 in Colombia: A cross-sectional study",

abstract = "Introduction Asymptomatic carriers (AC) of the new SARS-CoV-2 represent an important source of spread for COVID-19. Early diagnosis of these cases is a powerful tool to control the pandemic. Our objective was to characterise patients with AC status and identify associated sociodemographic factors. Methods Using a cross-sectional design and the national database of daily occurrence of COVID-19, we characterised both socially and demographically all ACs. Additional correspondence analysis and logistic regression model were performed to identify characteristics associated with AC state (OR, 95% CI). Results 76.162 ACs (12.1%; 95% CI 12.0% to 12.2%) were identified, mainly before epidemiological week 35. Age≤26 years (1.18; 1.09 to 1.28), male sex (1.51; 1.40 to 1.62), cases imported from Venezuela, Argentina, Brazil, Germany, Puerto Rico, Spain, USA or Mexico (12.6; 3.03 to 52.5) and autochthonous cases (22.6; 5.62 to 91.4) increased the risk of identifying ACs. We also identified groups of departments with moderate (1.23; 1.13 to 1.34) and strong (19.8; 18.6 to 21.0) association with ACs. Conclusion Sociodemographic characteristics strongly associated with AC were identified, which may explain its epidemiological relevance and usefulness to optimise mass screening strategies and prevent person-to-person transmission. ",

author = "Teher{\'a}n, {An{\'i}bal A.} and {Camero Ramos}, Gabriel and {Prado De La Guardia}, Ronald and Carolina Hern{\'a}ndez and Giovanny Herrera and Pombo, {Luis M.} and Avila, {Albert Alejandro} and Carolina Fl{\'o}rez and Barros, {Esther C.} and Luis Perez-Garcia and Alberto Paniz-Mondolfi and Ram{\'i}rez, {Juan David}",

year = "2020",

month = dec,

day = "7",

doi = "10.1136/bmjopen-2020-042122",

language = "English (US)",

volume = "10",

journal = "BMJ Open",

issn = "2044-6055",

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Teherán, AA, Camero Ramos, G, Prado De La Guardia, R, Hernández, C, Herrera, G, Pombo, LM, Avila, AA, Flórez, C, Barros, EC, Perez-Garcia, L, Paniz-Mondolfi, A & Ramírez, JD 2020, 'Epidemiological characterisation of asymptomatic carriers of COVID-19 in Colombia: A cross-sectional study', BMJ Open, vol. 10, n.º 12, e042122. https://doi.org/10.1136/bmjopen-2020-042122

TY - JOUR

T1 - Epidemiological characterisation of asymptomatic carriers of COVID-19 in Colombia

T2 - A cross-sectional study

AU - Teherán, Aníbal A.

AU - Camero Ramos, Gabriel

AU - Prado De La Guardia, Ronald

AU - Hernández, Carolina

AU - Herrera, Giovanny

AU - Pombo, Luis M.

AU - Avila, Albert Alejandro

AU - Flórez, Carolina

AU - Barros, Esther C.

AU - Perez-Garcia, Luis

AU - Paniz-Mondolfi, Alberto

AU - Ramírez, Juan David

PY - 2020/12/7

Y1 - 2020/12/7

N2 - Introduction Asymptomatic carriers (AC) of the new SARS-CoV-2 represent an important source of spread for COVID-19. Early diagnosis of these cases is a powerful tool to control the pandemic. Our objective was to characterise patients with AC status and identify associated sociodemographic factors. Methods Using a cross-sectional design and the national database of daily occurrence of COVID-19, we characterised both socially and demographically all ACs. Additional correspondence analysis and logistic regression model were performed to identify characteristics associated with AC state (OR, 95% CI). Results 76.162 ACs (12.1%; 95% CI 12.0% to 12.2%) were identified, mainly before epidemiological week 35. Age≤26 years (1.18; 1.09 to 1.28), male sex (1.51; 1.40 to 1.62), cases imported from Venezuela, Argentina, Brazil, Germany, Puerto Rico, Spain, USA or Mexico (12.6; 3.03 to 52.5) and autochthonous cases (22.6; 5.62 to 91.4) increased the risk of identifying ACs. We also identified groups of departments with moderate (1.23; 1.13 to 1.34) and strong (19.8; 18.6 to 21.0) association with ACs. Conclusion Sociodemographic characteristics strongly associated with AC were identified, which may explain its epidemiological relevance and usefulness to optimise mass screening strategies and prevent person-to-person transmission.

AB - Introduction Asymptomatic carriers (AC) of the new SARS-CoV-2 represent an important source of spread for COVID-19. Early diagnosis of these cases is a powerful tool to control the pandemic. Our objective was to characterise patients with AC status and identify associated sociodemographic factors. Methods Using a cross-sectional design and the national database of daily occurrence of COVID-19, we characterised both socially and demographically all ACs. Additional correspondence analysis and logistic regression model were performed to identify characteristics associated with AC state (OR, 95% CI). Results 76.162 ACs (12.1%; 95% CI 12.0% to 12.2%) were identified, mainly before epidemiological week 35. Age≤26 years (1.18; 1.09 to 1.28), male sex (1.51; 1.40 to 1.62), cases imported from Venezuela, Argentina, Brazil, Germany, Puerto Rico, Spain, USA or Mexico (12.6; 3.03 to 52.5) and autochthonous cases (22.6; 5.62 to 91.4) increased the risk of identifying ACs. We also identified groups of departments with moderate (1.23; 1.13 to 1.34) and strong (19.8; 18.6 to 21.0) association with ACs. Conclusion Sociodemographic characteristics strongly associated with AC were identified, which may explain its epidemiological relevance and usefulness to optimise mass screening strategies and prevent person-to-person transmission.

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DO - 10.1136/bmjopen-2020-042122

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Epidemiological characterisation of asymptomatic carriers of COVID-19 in Colombia: A cross-sectional study

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