[Bogota paint-industry workers exposure to organic solvents and genotoxic effects].

Omayda Cardenas-Bustamante, Marcela Varona-Uribe, Rosa I Patino-Florez, Helena Groot-Restrepo, Diana Sicard-Suarez, Maria M Torres-Carvajal, Dario Pardo-Pardo

Resultado de la investigación: Contribución a RevistaArtículo

Resumen

OBJECTIVE: Investigating the degree of exposure to organic solvents and related genotoxic consequences in paint-factory workers by using cytogenetic monitoring and determining micronuclei frequency in lymphocytes and DNA damage as assessed by comet assays. METHODOLOGY: Excretion of phenol and hippuric and methylhippuric acids in urine was investigated as biomarkers for benzene, toluene and xylene exposure. Urine samples were taken in two paint-factories in Bogota and in a non-exposed control group. Benzene, toluene and xylene concentrations in air were measured in the work setting. Micronuclei and simple DNA chain breakage frequency were evaluated in peripheral blood sample mononuclear cells to assess early genetic effects. RESULTS: Hippuric acid concentration was found to be within normal values; by contrast, phenol and methylhippuric acid sample concentrations were above normal values by 3,3 % and 50,8 %, respectively. Benzene concentration in air was above permissible limits in one of the factories. There were no statistical differences regarding genetic biomarkers between exposed and non-exposed workers. CONCLUSIONS: Organic solvent levels in the samples were apparently low, which is consistent with the absence of genotoxicity in cells. This study represents a step forward in research in occupational health surveillance.
Idioma originalEnglish (US)
Páginas (desde-hasta)275-288
Número de páginas14
PublicaciónRevista de salud publica (Bogota, Colombia)
Volumen9
N.º2
EstadoPublished - 2007

Huella dactilar

Paint
Benzene
Xylenes
Industry
Toluene
Phenol
Reference Values
Biomarkers
Air
Urine
Comet Assay
Occupational Health
Cytogenetics
DNA Damage
Lymphocytes
Control Groups
Acids
DNA
Research
hippuric acid

Citar esto

Cardenas-Bustamante, O., Varona-Uribe, M., Patino-Florez, R. I., Groot-Restrepo, H., Sicard-Suarez, D., Torres-Carvajal, M. M., & Pardo-Pardo, D. (2007). [Bogota paint-industry workers exposure to organic solvents and genotoxic effects]. Revista de salud publica (Bogota, Colombia), 9(2), 275-288.
Cardenas-Bustamante, Omayda ; Varona-Uribe, Marcela ; Patino-Florez, Rosa I ; Groot-Restrepo, Helena ; Sicard-Suarez, Diana ; Torres-Carvajal, Maria M ; Pardo-Pardo, Dario. / [Bogota paint-industry workers exposure to organic solvents and genotoxic effects]. En: Revista de salud publica (Bogota, Colombia). 2007 ; Vol. 9, N.º 2. pp. 275-288.
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title = "[Bogota paint-industry workers exposure to organic solvents and genotoxic effects].",
abstract = "OBJECTIVE: Investigating the degree of exposure to organic solvents and related genotoxic consequences in paint-factory workers by using cytogenetic monitoring and determining micronuclei frequency in lymphocytes and DNA damage as assessed by comet assays. METHODOLOGY: Excretion of phenol and hippuric and methylhippuric acids in urine was investigated as biomarkers for benzene, toluene and xylene exposure. Urine samples were taken in two paint-factories in Bogota and in a non-exposed control group. Benzene, toluene and xylene concentrations in air were measured in the work setting. Micronuclei and simple DNA chain breakage frequency were evaluated in peripheral blood sample mononuclear cells to assess early genetic effects. RESULTS: Hippuric acid concentration was found to be within normal values; by contrast, phenol and methylhippuric acid sample concentrations were above normal values by 3,3 {\%} and 50,8 {\%}, respectively. Benzene concentration in air was above permissible limits in one of the factories. There were no statistical differences regarding genetic biomarkers between exposed and non-exposed workers. CONCLUSIONS: Organic solvent levels in the samples were apparently low, which is consistent with the absence of genotoxicity in cells. This study represents a step forward in research in occupational health surveillance.",
author = "Omayda Cardenas-Bustamante and Marcela Varona-Uribe and Patino-Florez, {Rosa I} and Helena Groot-Restrepo and Diana Sicard-Suarez and Torres-Carvajal, {Maria M} and Dario Pardo-Pardo",
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Cardenas-Bustamante, O, Varona-Uribe, M, Patino-Florez, RI, Groot-Restrepo, H, Sicard-Suarez, D, Torres-Carvajal, MM & Pardo-Pardo, D 2007, '[Bogota paint-industry workers exposure to organic solvents and genotoxic effects].', Revista de salud publica (Bogota, Colombia), vol. 9, n.º 2, pp. 275-288.

[Bogota paint-industry workers exposure to organic solvents and genotoxic effects]. / Cardenas-Bustamante, Omayda; Varona-Uribe, Marcela; Patino-Florez, Rosa I; Groot-Restrepo, Helena; Sicard-Suarez, Diana; Torres-Carvajal, Maria M; Pardo-Pardo, Dario.

En: Revista de salud publica (Bogota, Colombia), Vol. 9, N.º 2, 2007, p. 275-288.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - [Bogota paint-industry workers exposure to organic solvents and genotoxic effects].

AU - Cardenas-Bustamante, Omayda

AU - Varona-Uribe, Marcela

AU - Patino-Florez, Rosa I

AU - Groot-Restrepo, Helena

AU - Sicard-Suarez, Diana

AU - Torres-Carvajal, Maria M

AU - Pardo-Pardo, Dario

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: Investigating the degree of exposure to organic solvents and related genotoxic consequences in paint-factory workers by using cytogenetic monitoring and determining micronuclei frequency in lymphocytes and DNA damage as assessed by comet assays. METHODOLOGY: Excretion of phenol and hippuric and methylhippuric acids in urine was investigated as biomarkers for benzene, toluene and xylene exposure. Urine samples were taken in two paint-factories in Bogota and in a non-exposed control group. Benzene, toluene and xylene concentrations in air were measured in the work setting. Micronuclei and simple DNA chain breakage frequency were evaluated in peripheral blood sample mononuclear cells to assess early genetic effects. RESULTS: Hippuric acid concentration was found to be within normal values; by contrast, phenol and methylhippuric acid sample concentrations were above normal values by 3,3 % and 50,8 %, respectively. Benzene concentration in air was above permissible limits in one of the factories. There were no statistical differences regarding genetic biomarkers between exposed and non-exposed workers. CONCLUSIONS: Organic solvent levels in the samples were apparently low, which is consistent with the absence of genotoxicity in cells. This study represents a step forward in research in occupational health surveillance.

AB - OBJECTIVE: Investigating the degree of exposure to organic solvents and related genotoxic consequences in paint-factory workers by using cytogenetic monitoring and determining micronuclei frequency in lymphocytes and DNA damage as assessed by comet assays. METHODOLOGY: Excretion of phenol and hippuric and methylhippuric acids in urine was investigated as biomarkers for benzene, toluene and xylene exposure. Urine samples were taken in two paint-factories in Bogota and in a non-exposed control group. Benzene, toluene and xylene concentrations in air were measured in the work setting. Micronuclei and simple DNA chain breakage frequency were evaluated in peripheral blood sample mononuclear cells to assess early genetic effects. RESULTS: Hippuric acid concentration was found to be within normal values; by contrast, phenol and methylhippuric acid sample concentrations were above normal values by 3,3 % and 50,8 %, respectively. Benzene concentration in air was above permissible limits in one of the factories. There were no statistical differences regarding genetic biomarkers between exposed and non-exposed workers. CONCLUSIONS: Organic solvent levels in the samples were apparently low, which is consistent with the absence of genotoxicity in cells. This study represents a step forward in research in occupational health surveillance.

M3 - Article

VL - 9

SP - 275

EP - 288

IS - 2

ER -

Cardenas-Bustamante O, Varona-Uribe M, Patino-Florez RI, Groot-Restrepo H, Sicard-Suarez D, Torres-Carvajal MM y otros. [Bogota paint-industry workers exposure to organic solvents and genotoxic effects]. Revista de salud publica (Bogota, Colombia). 2007;9(2):275-288.