Development of a genome editing platform, using the CRISPR-Cas9 technique, for the treatment of orphan diseases associated with thoracic aortic aneurysms.

Medicine & Life Sciences

1. Gene Editing 100%
2. Thoracic Aortic Aneurysm 80%
3. Rare Diseases 39%
4. Technology 26%
5. Aortic Aneurysm 23%
6. Clustered Regularly Interspaced Short Palindromic Repeats 23%
7. Mutation 22%
8. Extracellular Matrix Proteins 22%
9. Feasibility Studies 21%
10. Nucleic Acids 20%
11. Cardiovascular System 20%
12. Aorta 17%
13. Extracellular Matrix 17%
14. Cell Culture Techniques 15%
15. Alleles 14%
16. Animal Models 14%
17. Genome 13%
18. Pathology 12%
19. Phenotype 12%
20. Safety 11%
21. In Vitro Techniques 8%
22. Proteins 7%