Developing an anti-malarial vaccine represents a dynamic area for exploration, even though one having enormous challenges, especially due to the complexity of the parasite’s lifecycle. Plasmodium falciparum’s different invasion stages must thus be blocked and the greatest amount of information possible concerning the artillery to be used in its attack must be extracted from them. Peptides from (sporozoite-derived) STARP, CelTOS and TRSP and (merozoite-derived) SERA 5 proteins having high binding affinity for HepG2 cells and red blood cells, respectively (known as conserved HABPs), have thus been modified, synthesised and evaluated at immune response level in Aotus monkeys as well as having been studied regarding their structural conformation by 1H-NMR.
|Fecha de adjudicación||may 26 2015|
|Idioma original||Español (Colombia)|
|Supervisor||Manuel Elkin Patarroyo (Supervisor)|