Zinc and epilepsy: Is there a causal relation between them?

C. B. Moreno, Ángela Maria Gutiérrez-Álvarez, R. E. González-Reyes

Resultado de la investigación: Contribución a RevistaRevisión Literaria

4 Citas (Scopus)

Resumen

Introduction. Zinc is a fundamental trace element for an adequate nervous system function. It has been suggested that in the brain, a zinc homeostasis alteration may be associated with the genesis of epilepsy, although it is not yet determined if concentrations of zinc are a cause or a consequence of seizures. Another poorly studied aspect is the relationship between antiepileptic drugs and the neuronal zinc behaviour. Development. We perform a systematic review of the literature to evaluate the role that zinc plays in epilepsy as well as the antiepileptic effect of zinc concentrations. Databases such as MEDLINE, EMBASE, SCISEARCH and LILACS were consulted from January 1974 to July 2005. All articles published in English and Spanish were considered. A manual review of the references present in each article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles that seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. Clinical research in epilepsy presented contradictory results. In fact, the reviewed studies, both animal and human, did not give enough evidence to determine if organic zinc variations are directly related to epilepsy. Most of them gave not statistically significant results. © 2006, Revista de Neurología.
Idioma originalEnglish (US)
Páginas (desde-hasta)754-759
Número de páginas6
PublicaciónRevista de Neurologia
EstadoPublished - jun 1 2006

Huella dactilar

Zinc
Epilepsy
Anticonvulsants
Trace Elements
MEDLINE
Nervous System
Seizures
Homeostasis
Databases
Brain
Research

Citar esto

Moreno, C. B., Gutiérrez-Álvarez, Á. M., & González-Reyes, R. E. (2006). Zinc and epilepsy: Is there a causal relation between them? Revista de Neurologia, 754-759.
Moreno, C. B. ; Gutiérrez-Álvarez, Ángela Maria ; González-Reyes, R. E. / Zinc and epilepsy: Is there a causal relation between them?. En: Revista de Neurologia. 2006 ; pp. 754-759.
@article{5e120638545a4ae39a0b59a69e25c48b,
title = "Zinc and epilepsy: Is there a causal relation between them?",
abstract = "Introduction. Zinc is a fundamental trace element for an adequate nervous system function. It has been suggested that in the brain, a zinc homeostasis alteration may be associated with the genesis of epilepsy, although it is not yet determined if concentrations of zinc are a cause or a consequence of seizures. Another poorly studied aspect is the relationship between antiepileptic drugs and the neuronal zinc behaviour. Development. We perform a systematic review of the literature to evaluate the role that zinc plays in epilepsy as well as the antiepileptic effect of zinc concentrations. Databases such as MEDLINE, EMBASE, SCISEARCH and LILACS were consulted from January 1974 to July 2005. All articles published in English and Spanish were considered. A manual review of the references present in each article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles that seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. Clinical research in epilepsy presented contradictory results. In fact, the reviewed studies, both animal and human, did not give enough evidence to determine if organic zinc variations are directly related to epilepsy. Most of them gave not statistically significant results. {\circledC} 2006, Revista de Neurolog{\'i}a.",
author = "Moreno, {C. B.} and Guti{\'e}rrez-{\'A}lvarez, {{\'A}ngela Maria} and Gonz{\'a}lez-Reyes, {R. E.}",
year = "2006",
month = "6",
day = "1",
language = "English (US)",
pages = "754--759",
journal = "Revista de Neurologia",
issn = "0210-0010",
publisher = "Revista de Neurologia",

}

Moreno, CB, Gutiérrez-Álvarez, ÁM & González-Reyes, RE 2006, 'Zinc and epilepsy: Is there a causal relation between them?', Revista de Neurologia, pp. 754-759.

Zinc and epilepsy: Is there a causal relation between them? / Moreno, C. B.; Gutiérrez-Álvarez, Ángela Maria; González-Reyes, R. E.

En: Revista de Neurologia, 01.06.2006, p. 754-759.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - Zinc and epilepsy: Is there a causal relation between them?

AU - Moreno, C. B.

AU - Gutiérrez-Álvarez, Ángela Maria

AU - González-Reyes, R. E.

PY - 2006/6/1

Y1 - 2006/6/1

N2 - Introduction. Zinc is a fundamental trace element for an adequate nervous system function. It has been suggested that in the brain, a zinc homeostasis alteration may be associated with the genesis of epilepsy, although it is not yet determined if concentrations of zinc are a cause or a consequence of seizures. Another poorly studied aspect is the relationship between antiepileptic drugs and the neuronal zinc behaviour. Development. We perform a systematic review of the literature to evaluate the role that zinc plays in epilepsy as well as the antiepileptic effect of zinc concentrations. Databases such as MEDLINE, EMBASE, SCISEARCH and LILACS were consulted from January 1974 to July 2005. All articles published in English and Spanish were considered. A manual review of the references present in each article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles that seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. Clinical research in epilepsy presented contradictory results. In fact, the reviewed studies, both animal and human, did not give enough evidence to determine if organic zinc variations are directly related to epilepsy. Most of them gave not statistically significant results. © 2006, Revista de Neurología.

AB - Introduction. Zinc is a fundamental trace element for an adequate nervous system function. It has been suggested that in the brain, a zinc homeostasis alteration may be associated with the genesis of epilepsy, although it is not yet determined if concentrations of zinc are a cause or a consequence of seizures. Another poorly studied aspect is the relationship between antiepileptic drugs and the neuronal zinc behaviour. Development. We perform a systematic review of the literature to evaluate the role that zinc plays in epilepsy as well as the antiepileptic effect of zinc concentrations. Databases such as MEDLINE, EMBASE, SCISEARCH and LILACS were consulted from January 1974 to July 2005. All articles published in English and Spanish were considered. A manual review of the references present in each article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles that seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. Clinical research in epilepsy presented contradictory results. In fact, the reviewed studies, both animal and human, did not give enough evidence to determine if organic zinc variations are directly related to epilepsy. Most of them gave not statistically significant results. © 2006, Revista de Neurología.

M3 - Literature review

SP - 754

EP - 759

JO - Revista de Neurologia

JF - Revista de Neurologia

SN - 0210-0010

ER -

Moreno CB, Gutiérrez-Álvarez ÁM, González-Reyes RE. Zinc and epilepsy: Is there a causal relation between them? Revista de Neurologia. 2006 jun 1;754-759.