Zika virus and neurologic autoimmunity

the putative role of gangliosides

Juan-Manuel Anaya, Carolina Ramirez-Santana, Ignacio Salgado-Castaneda, Christopher Chang, Aftab Ansari, M. Eric Gershwin

Resultado de la investigación: Contribución a RevistaArtículo

32 Citas (Scopus)

Resumen

An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.

Idioma originalEnglish (US)
Páginas (desde-hasta)49
Número de páginas3
PublicaciónBMC Medicine
Volumen14
DOI
EstadoPublished - mar 21 2016
Publicado de forma externa

Huella dactilar

Gangliosides
Autoimmunity
Nervous System
Microcephaly
Guillain-Barre Syndrome
Molecular Mimicry
Glycolipids
Neurogenesis
Synaptic Transmission
Emergencies
Cell Proliferation
Incidence
Brain
Infection
Zika Virus

Citar esto

Anaya, J-M., Ramirez-Santana, C., Salgado-Castaneda, I., Chang, C., Ansari, A., & Gershwin, M. E. (2016). Zika virus and neurologic autoimmunity: the putative role of gangliosides. BMC Medicine, 14, 49. https://doi.org/10.1186/s12916-016-0601-y
Anaya, Juan-Manuel ; Ramirez-Santana, Carolina ; Salgado-Castaneda, Ignacio ; Chang, Christopher ; Ansari, Aftab ; Gershwin, M. Eric. / Zika virus and neurologic autoimmunity : the putative role of gangliosides. En: BMC Medicine. 2016 ; Vol. 14. pp. 49.
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Anaya, J-M, Ramirez-Santana, C, Salgado-Castaneda, I, Chang, C, Ansari, A & Gershwin, ME 2016, 'Zika virus and neurologic autoimmunity: the putative role of gangliosides', BMC Medicine, vol. 14, pp. 49. https://doi.org/10.1186/s12916-016-0601-y

Zika virus and neurologic autoimmunity : the putative role of gangliosides. / Anaya, Juan-Manuel; Ramirez-Santana, Carolina; Salgado-Castaneda, Ignacio; Chang, Christopher; Ansari, Aftab; Gershwin, M. Eric.

En: BMC Medicine, Vol. 14, 21.03.2016, p. 49.

Resultado de la investigación: Contribución a RevistaArtículo

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T2 - the putative role of gangliosides

AU - Anaya, Juan-Manuel

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AU - Ansari, Aftab

AU - Gershwin, M. Eric

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Anaya J-M, Ramirez-Santana C, Salgado-Castaneda I, Chang C, Ansari A, Gershwin ME. Zika virus and neurologic autoimmunity: the putative role of gangliosides. BMC Medicine. 2016 mar 21;14:49. https://doi.org/10.1186/s12916-016-0601-y