Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview

María Alejandra Cerquera; Mauricio Orlando Nava Mesa; Rodrigo Esteban Gonzalez Reyes; Carlos  Tellez-Conti; Ligia Alejandra Delatorre Cifuentes

doi:10.1155/2018/2941783

Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview

Título traducido de la contribución: CARACTERÍSTICAS VISUALES EN LA ENFERMEDAD DE ALZHEIMER: DE MECANISMOS BÁSICOS A VISIÓN CLÍNICA

Producción científica: Contribución a revista › Artículo de revisión › revisión exhaustiva

47 Citas (Scopus)

Resumen

La enfermedad de Alzheimer (EA) es la principal causa de demencia en todo el mundo. Compromete las actividades diarias de los pacientes debido al deterioro cognitivo progresivo, que ha elevado los costos directos e indirectos. Aunque AD tiene varios factores de riesgo, el envejecimiento se considera el más importante. Desafortunadamente, el diagnóstico clínico generalmente se realiza en una etapa avanzada de la enfermedad cuando se establece la demencia, lo que dificulta la implementación de intervenciones terapéuticas exitosas. Los biomarcadores actuales tienden a ser costosos, insuficientes o invasivos, lo que aumenta la necesidad de herramientas nuevas y mejoradas destinadas a la detección temprana de enfermedades. La AD se caracteriza por atrofia cerebral debida a pérdida neuronal y sináptica, placas amiloides extracelulares compuestas de péptido beta amiloide (Aβ) y marañas neurofibrilares de proteína Tau hiperfosforilada. El sistema visual y el sistema nervioso central comparten muchos componentes funcionales. Por lo tanto, es plausible que el daño inducido por Aβ, Tau y neuroinflamación se pueda observar en componentes visuales tales como la retina, incluso en una etapa temprana de la enfermedad. Esto subraya la importancia de implementar exámenes oftalmológicos, menos invasivos y caros que otros biomarcadores, como medidas útiles para evaluar la progresión y gravedad de la enfermedad en individuos con o en riesgo de AD. Aquí, revisamos los cambios funcionales y morfológicos de la retina y la vía visual en AD desde perspectivas fisiopatológicas y clínicas

Título traducido de la contribución	CARACTERÍSTICAS VISUALES EN LA ENFERMEDAD DE ALZHEIMER: DE MECANISMOS BÁSICOS A VISIÓN CLÍNICA
Idioma original	Inglés estadounidense
Número de artículo	2941783
Páginas (desde-hasta)	1-21
Número de páginas	21
Publicación	Neural Plasticity
Volumen	2018
DOI	https://doi.org/10.1155/2018/2941783
Estado	Publicada - nov. 14 2018

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@article{c8c29c29756f469dab239d4ce8e0c8d8,

title = "Visual Features in Alzheimer{\textquoteright}s Disease: From Basic Mechanisms to Clinical Overview",

abstract = "Alzheimer's disease (AD) is the leading cause of dementia worldwide. It compromises patients{\textquoteright} daily activities owing to progressive cognitive deterioration, which has elevated direct and indirect costs. Although AD has several risk factors, aging is considered the most important. Unfortunately, clinical diagnosis is usually performed at an advanced disease stage when dementia is established, making implementation of successful therapeutic interventions difficult. Current biomarkers tend to be expensive, insufficient, or invasive, raising the need for novel, improved tools aimed at early disease detection. AD is characterized by brain atrophy due to neuronal and synaptic loss, extracellular amyloid plaques composed of amyloid-beta peptide (Aβ), and neurofibrillary tangles of hyperphosphorylated Tau protein. The visual system and central nervous system share many functional components. Thus, it is plausible that damage induced by Aβ, Tau, and neuroinflammation may be observed in visual components such as the retina, even at an early disease stage. This underscores the importance of implementing ophthalmological examinations, less invasive and expensive than other biomarkers, as useful measures to assess disease progression and severity in individuals with or at risk of AD. Here, we review functional and morphological changes of the retina and visual pathway in AD from pathophysiological and clinical perspectives. ",

author = "Cerquera, \{Mar{\'i}a Alejandra\} and \{Nava Mesa\}, \{Mauricio Orlando\} and \{Gonzalez Reyes\}, \{Rodrigo Esteban\} and Carlos Tellez-Conti and \{Delatorre Cifuentes\}, \{Ligia Alejandra\}",

year = "2018",

month = nov,

day = "14",

doi = "10.1155/2018/2941783",

language = "English (US)",

volume = "2018",

pages = "1--21",

journal = "Neural Plasticity",

issn = "2090-5904",

publisher = "John Wiley and Sons Ltd",

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T1 - Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview

AU - Cerquera, María Alejandra

AU - Nava Mesa, Mauricio Orlando

AU - Gonzalez Reyes, Rodrigo Esteban

AU - Tellez-Conti, Carlos

AU - Delatorre Cifuentes, Ligia Alejandra

PY - 2018/11/14

Y1 - 2018/11/14

N2 - Alzheimer's disease (AD) is the leading cause of dementia worldwide. It compromises patients’ daily activities owing to progressive cognitive deterioration, which has elevated direct and indirect costs. Although AD has several risk factors, aging is considered the most important. Unfortunately, clinical diagnosis is usually performed at an advanced disease stage when dementia is established, making implementation of successful therapeutic interventions difficult. Current biomarkers tend to be expensive, insufficient, or invasive, raising the need for novel, improved tools aimed at early disease detection. AD is characterized by brain atrophy due to neuronal and synaptic loss, extracellular amyloid plaques composed of amyloid-beta peptide (Aβ), and neurofibrillary tangles of hyperphosphorylated Tau protein. The visual system and central nervous system share many functional components. Thus, it is plausible that damage induced by Aβ, Tau, and neuroinflammation may be observed in visual components such as the retina, even at an early disease stage. This underscores the importance of implementing ophthalmological examinations, less invasive and expensive than other biomarkers, as useful measures to assess disease progression and severity in individuals with or at risk of AD. Here, we review functional and morphological changes of the retina and visual pathway in AD from pathophysiological and clinical perspectives.

AB - Alzheimer's disease (AD) is the leading cause of dementia worldwide. It compromises patients’ daily activities owing to progressive cognitive deterioration, which has elevated direct and indirect costs. Although AD has several risk factors, aging is considered the most important. Unfortunately, clinical diagnosis is usually performed at an advanced disease stage when dementia is established, making implementation of successful therapeutic interventions difficult. Current biomarkers tend to be expensive, insufficient, or invasive, raising the need for novel, improved tools aimed at early disease detection. AD is characterized by brain atrophy due to neuronal and synaptic loss, extracellular amyloid plaques composed of amyloid-beta peptide (Aβ), and neurofibrillary tangles of hyperphosphorylated Tau protein. The visual system and central nervous system share many functional components. Thus, it is plausible that damage induced by Aβ, Tau, and neuroinflammation may be observed in visual components such as the retina, even at an early disease stage. This underscores the importance of implementing ophthalmological examinations, less invasive and expensive than other biomarkers, as useful measures to assess disease progression and severity in individuals with or at risk of AD. Here, we review functional and morphological changes of the retina and visual pathway in AD from pathophysiological and clinical perspectives.

UR - https://www.hindawi.com/journals/np/2018/2941783/

U2 - 10.1155/2018/2941783

DO - 10.1155/2018/2941783

M3 - Review article

SN - 2090-5904

VL - 2018

SP - 1

EP - 21

JO - Neural Plasticity

JF - Neural Plasticity

M1 - 2941783

ER -

Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview

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