TY - JOUR
T1 - Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
AU - Lessard, Christopher J.
AU - Li, He
AU - Adrianto, Indra
AU - Ice, John A.
AU - Rasmussen, Astrid
AU - Grundahl, Kiely M.
AU - Kelly, Jennifer A.
AU - Dozmorov, Mikhail G.
AU - Miceli-Richard, Corinne
AU - Bowman, Simon
AU - Lester, Sue
AU - Eriksson, Per
AU - Eloranta, Maija Leena
AU - Brun, Johan G.
AU - Gøransson, Lasse G.
AU - Harboe, Erna
AU - Guthridge, Joel M.
AU - Kaufman, Kenneth M.
AU - Kvarnström, Marika
AU - Jazebi, Helmi
AU - Graham, Deborah S.Cunninghame
AU - Grandits, Martha E.
AU - Nazmul-Hossain, Abu N.M.
AU - Patel, Ketan
AU - Adler, Adam J.
AU - Maier-Moore, Jacen S.
AU - Farris, A. Darise
AU - Brennan, Michael T.
AU - Lessard, James A.
AU - Chodosh, James
AU - Gopalakrishnan, Rajaram
AU - Hefner, Kimberly S.
AU - Houston, Glen D.
AU - Huang, Andrew J.W.
AU - Hughes, Pamela J.
AU - Lewis, David M.
AU - Radfar, Lida
AU - Rohrer, Michael D.
AU - Stone, Donald U.
AU - Wren, Jonathan D.
AU - Vyse, Timothy J.
AU - Gaffney, Patrick M.
AU - James, Judith A.
AU - Omdal, Roald
AU - Wahren-Herlenius, Marie
AU - Illei, Gabor G.
AU - Witte, Torsten
AU - Jonsson, Roland
AU - Rischmueller, Maureen
AU - Anaya, Juan Manuel
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (P meta = 7.65 × 10 -114), we establish associations with IRF5-TNPO3 (P meta = 2.73 × 10 -19), STAT4 (P meta = 6.80 × 10 -15), IL12A (P meta = 1.17 × 10 -10), FAM167A-BLK (P meta = 4.97 × 10 -10), DDX6-CXCR5 (P meta = 1.10 × 10 -8) and TNIP1 (P meta = 3.30 × 10 -8). We also observed suggestive associations (P meta < 5 × 10 -5) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome.
AB - Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjögren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (P meta = 7.65 × 10 -114), we establish associations with IRF5-TNPO3 (P meta = 2.73 × 10 -19), STAT4 (P meta = 6.80 × 10 -15), IL12A (P meta = 1.17 × 10 -10), FAM167A-BLK (P meta = 4.97 × 10 -10), DDX6-CXCR5 (P meta = 1.10 × 10 -8) and TNIP1 (P meta = 3.30 × 10 -8). We also observed suggestive associations (P meta < 5 × 10 -5) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome.
UR - http://www.scopus.com/inward/record.url?scp=84887116043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887116043&partnerID=8YFLogxK
U2 - 10.1038/ng.2792
DO - 10.1038/ng.2792
M3 - Article
C2 - 24097067
AN - SCOPUS:84887116043
SN - 1061-4036
VL - 45
SP - 1284
EP - 1294
JO - Nature Genetics
JF - Nature Genetics
IS - 11
ER -
