Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏

Alejandra de-la-Torre; Juanita Valdes-Camacho; C. Stephen Foster

doi:10.3109/09273948.2016.1142572

Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏

Título traducido de la contribución: Uveítis bilateral por Herpes simple: revisión de la literatura y reportes propios

Alejandra de-la-Torre, Juanita Valdes-Camacho, C. Stephen Foster

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

11 Citas (Scopus)

Resumen

Propósito: la uveítis asociada al Herpes simple generalmente se considera una enfermedad ocular unilateral, y rara vez se incluye en el diagnóstico diferencial siempre que exista afectación bilateral. Presentamos tres casos de uveítis anterior herpética bilateral. Métodos: se evaluaron tres pacientes que presentaban manifestaciones clínicas de uveítis bilateral sugestiva de origen viral. Resultados: encontramos hipertensión intraocular, células en la cámara anterior, midriasis paralítica, atrofia del iris con defectos de transiluminación y celularidad vítrea anterior variable. De acuerdo con los hallazgos clínicos, respaldados por títulos de anticuerpos específicos contra el herpes y resultados de PCR con humor acuoso en dos de ellos, se les diagnosticó uveítis herpética anterior bilateral. Conclusiones: Nuestros pacientes inicialmente fueron mal diagnosticados con uveítis no infecciosa y fueron tratados con medicamentos inmunomoduladores, lo que podría haber favorecido la extensión de la infección bilateralmente. Aunque es poco frecuente, la uveítis herpética bilateral siempre debe considerarse en el diagnóstico diferencial, cuando los pacientes presentan uveítis hipertensiva en ambos ojos

Título traducido de la contribución	Uveítis bilateral por Herpes simple: revisión de la literatura y reportes propios
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1-6
Número de páginas	6
Publicación	Ocular Immunology and Inflammation
Volumen	25
N.º	4
Fecha en línea anticipada	mar. 20 2016
DOI	https://doi.org/10.3109/09273948.2016.1142572
Estado	Publicada - ene. 1 2017

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title = "Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏",

abstract = "Purpose: Herpes simplex-associated uveitis is usually considered a unilateral eye disease, and rarely included in the differential diagnosis whenever there is bilateral involvement. We report three cases of bilateral herpetic anterior uveitis. Methods: We evaluated three patients who presented with clinical manifestations of bilateral uveitis suggestive of viral origin. Results: We found intraocular hypertension, cells in the anterior chamber, paralytic mydriasis, iris atrophy with transillumination defects, and variable anterior vitreous cellularity. According to the clinical findings, supported with herpes-specific antibody titers and aqueous humor PCR results in two of them, they were diagnosed with bilateral anterior herpetic uveitis. Conclusions: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes.",

author = "Alejandra de-la-Torre and Juanita Valdes-Camacho and Foster, {C. Stephen}",

year = "2017",

month = jan,

day = "1",

doi = "10.3109/09273948.2016.1142572",

language = "English (US)",

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T1 - Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏

AU - de-la-Torre, Alejandra

AU - Valdes-Camacho, Juanita

AU - Foster, C. Stephen

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose: Herpes simplex-associated uveitis is usually considered a unilateral eye disease, and rarely included in the differential diagnosis whenever there is bilateral involvement. We report three cases of bilateral herpetic anterior uveitis. Methods: We evaluated three patients who presented with clinical manifestations of bilateral uveitis suggestive of viral origin. Results: We found intraocular hypertension, cells in the anterior chamber, paralytic mydriasis, iris atrophy with transillumination defects, and variable anterior vitreous cellularity. According to the clinical findings, supported with herpes-specific antibody titers and aqueous humor PCR results in two of them, they were diagnosed with bilateral anterior herpetic uveitis. Conclusions: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes.

AB - Purpose: Herpes simplex-associated uveitis is usually considered a unilateral eye disease, and rarely included in the differential diagnosis whenever there is bilateral involvement. We report three cases of bilateral herpetic anterior uveitis. Methods: We evaluated three patients who presented with clinical manifestations of bilateral uveitis suggestive of viral origin. Results: We found intraocular hypertension, cells in the anterior chamber, paralytic mydriasis, iris atrophy with transillumination defects, and variable anterior vitreous cellularity. According to the clinical findings, supported with herpes-specific antibody titers and aqueous humor PCR results in two of them, they were diagnosed with bilateral anterior herpetic uveitis. Conclusions: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes.

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Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏

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