Using the PfEMP1 head structure binding motif to deal a blow at severe malaria

Manuel E. Patarroyo, Martha Patricia Alba, Hernando Curtidor, Magnolia Vanegas, Hannia Almonacid, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

7 Citas (Scopus)

Resumen

Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ,1 million deaths and ∼100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (Pf EMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this ∼300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria. © 2014 Patarroyo et al.
Idioma originalEnglish (US)
PublicaciónPLoS One
DOI
EstadoPublished - feb 7 2014

Huella dactilar

Chondroitin Sulfates
malaria
Malaria
erythrocytes
Erythrocytes
Head
chondroitin sulfate
Peptides
Endothelial cells
Plasmodium falciparum
Cerebral Malaria
Rosette Formation
Blood
Vaccines
Falciparum Malaria
Cells
peptides
Blood Group Antigens
Aotus (Cebidae)
abortion (animals)

Citar esto

Patarroyo, Manuel E. ; Alba, Martha Patricia ; Curtidor, Hernando ; Vanegas, Magnolia ; Almonacid, Hannia ; Patarroyo, Manuel A. / Using the PfEMP1 head structure binding motif to deal a blow at severe malaria. En: PLoS One. 2014.
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title = "Using the PfEMP1 head structure binding motif to deal a blow at severe malaria",
abstract = "Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ,1 million deaths and ∼100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (Pf EMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this ∼300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria. {\circledC} 2014 Patarroyo et al.",
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Using the PfEMP1 head structure binding motif to deal a blow at severe malaria. / Patarroyo, Manuel E.; Alba, Martha Patricia; Curtidor, Hernando; Vanegas, Magnolia; Almonacid, Hannia; Patarroyo, Manuel A.

En: PLoS One, 07.02.2014.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Using the PfEMP1 head structure binding motif to deal a blow at severe malaria

AU - Patarroyo, Manuel E.

AU - Alba, Martha Patricia

AU - Curtidor, Hernando

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AU - Almonacid, Hannia

AU - Patarroyo, Manuel A.

PY - 2014/2/7

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AB - Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ,1 million deaths and ∼100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (Pf EMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this ∼300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria. © 2014 Patarroyo et al.

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