Update on safety profiles of vitamins B1, B6, and B12: A narrative review

Carlos Alberto Calderon-Ospina; Mauricio Orlando Nava-Mesa; Ana María Paez-Hurtado

doi:10.2147/TCRM.S274122

Update on safety profiles of vitamins B1, B6, and B12: A narrative review

Título traducido de la contribución: Actualización del perfil de seguridad de las vitaminas B1, B6 y B12. : Una revisión narrativa

Carlos Alberto Calderon-Ospina, Mauricio Orlando Nava-Mesa, Ana María Paez-Hurtado

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

19 Citas (Scopus)

Resumen

Las vitaminas B neurotrópicas B1 (tiamina), B6 (piridoxina) y B12 (cobalamina) son esenciales para el buen funcionamiento del sistema nervioso. Las deficiencias pueden inducir trastornos neurológicos como la neuropatía periférica (NP) y se producen principalmente en poblaciones vulnerables (p. Ej., Ancianos, diabéticos, alcohólicos). Dado que los estudios de cohortes epidemiológicos plantearon preocupaciones de seguridad acerca de la posible asociación de la ingesta de vitamina B6 / B12 con un mayor riesgo de fractura de cadera (IC) y cáncer de pulmón (CP), exploramos estos aspectos y realizamos búsquedas exhaustivas de la literatura. Sin embargo, sugerimos no descuidar los factores reales de alto riesgo (p. Ej., Fumar en CL, mayor edad en IC) centrándose en los nutrientes individuales, sino examinar la compleja interacción de numerosos factores implicados en el desarrollo de la enfermedad. Debido a que merece una consideración continua, también proporcionamos una actualización sobre la neurotoxicidad asociada con la vitamina B6. Consideramos que los efectos secundarios neurológicos debidos a la ingesta de vitamina B6 son raros y solo ocurren con dosis altas diarias y / o mayor duración del tratamiento. Por tanto, la relación beneficio-riesgo del tratamiento a dosis altas con vitaminas del grupo B neurotrópicas en indicaciones como la NP se considera ventajosa, especialmente si se siguen las recomendaciones posológicas y se controlan los niveles séricos.

Título traducido de la contribución	Actualización del perfil de seguridad de las vitaminas B1, B6 y B12. : Una revisión narrativa
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1275-1288
Número de páginas	14
Publicación	Therapeutics and Clinical Risk Management
Volumen	16
DOI	https://doi.org/10.2147/TCRM.S274122
Estado	Publicada - dic. 20 2020

Áreas temáticas de ASJC Scopus

Investigación sobre seguridad
Farmacología, toxicología y ciencias farmacéuticas (todo)
Farmacología (médica)
Salud y seguridad química

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.2147/TCRM.S274122

Otros archivos y enlaces

Citar esto

@article{6477500cc4cb49778f678a25937a83f9,

title = "Update on safety profiles of vitamins B1, B6, and B12: A narrative review",

abstract = "The neurotropic B vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) are essential for proper functioning of the nervous system. Deficiencies may induce neurological disorders like peripheral neuropathy (PN) and mainly occur in vulnerable populations (eg, elderly, diabetics, alcoholics). As epidemiologic cohort studies raised safety concerns about vitamin B6/B12 intake being potentially associated with increased risks of hip fracture (HF) and lung cancer (LC), we explored these aspects and performed comprehensive literature searches. However, we suggest not to neglect actual high-risk factors (eg, smoking in LC, higher age in HF) by focusing on individual nutrients, but to examine the complex interaction of numerous factors involved in disease development. Because it warrants continued consideration, we also provide an update on neurotoxicity associated with vitamin B6. We consider that neurological side effects due to vitamin B6 intake are rare and only occur with high daily doses and/or longer treatment duration. The benefit-risk ratio of high-dose treatment with neurotropic B vitamins in indications like PN is therefore considered advantageous, particularly if dosing recommendations are followed and serum levels monitored.",

author = "Calderon-Ospina, {Carlos Alberto} and Nava-Mesa, {Mauricio Orlando} and Paez-Hurtado, {Ana Mar{\'i}a}",

note = "Funding Information: Medical writing assistance was provided by Dittmann Medical W riting (Hamburg, Germany), the work was funded by P&G Health International. Funding Information: The work was funded by P&G Health International. C. Calderon-Ospina holds consultative activities for P&G Health International and reports personal fees from them outside the submitted work. The authors report no other potential conflicts of interest for this work. Publisher Copyright: {\textcopyright} 2020 Calderon-Ospina et al. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2020",

month = dec,

day = "20",

doi = "10.2147/TCRM.S274122",

language = "English (US)",

volume = "16",

pages = "1275--1288",

journal = "Therapeutics and Clinical Risk Management",

issn = "1176-6336",

publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Update on safety profiles of vitamins B1, B6, and B12

T2 - A narrative review

AU - Calderon-Ospina, Carlos Alberto

AU - Nava-Mesa, Mauricio Orlando

AU - Paez-Hurtado, Ana María

N1 - Funding Information: Medical writing assistance was provided by Dittmann Medical W riting (Hamburg, Germany), the work was funded by P&G Health International. Funding Information: The work was funded by P&G Health International. C. Calderon-Ospina holds consultative activities for P&G Health International and reports personal fees from them outside the submitted work. The authors report no other potential conflicts of interest for this work. Publisher Copyright: © 2020 Calderon-Ospina et al. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2020/12/20

Y1 - 2020/12/20

N2 - The neurotropic B vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) are essential for proper functioning of the nervous system. Deficiencies may induce neurological disorders like peripheral neuropathy (PN) and mainly occur in vulnerable populations (eg, elderly, diabetics, alcoholics). As epidemiologic cohort studies raised safety concerns about vitamin B6/B12 intake being potentially associated with increased risks of hip fracture (HF) and lung cancer (LC), we explored these aspects and performed comprehensive literature searches. However, we suggest not to neglect actual high-risk factors (eg, smoking in LC, higher age in HF) by focusing on individual nutrients, but to examine the complex interaction of numerous factors involved in disease development. Because it warrants continued consideration, we also provide an update on neurotoxicity associated with vitamin B6. We consider that neurological side effects due to vitamin B6 intake are rare and only occur with high daily doses and/or longer treatment duration. The benefit-risk ratio of high-dose treatment with neurotropic B vitamins in indications like PN is therefore considered advantageous, particularly if dosing recommendations are followed and serum levels monitored.

AB - The neurotropic B vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) are essential for proper functioning of the nervous system. Deficiencies may induce neurological disorders like peripheral neuropathy (PN) and mainly occur in vulnerable populations (eg, elderly, diabetics, alcoholics). As epidemiologic cohort studies raised safety concerns about vitamin B6/B12 intake being potentially associated with increased risks of hip fracture (HF) and lung cancer (LC), we explored these aspects and performed comprehensive literature searches. However, we suggest not to neglect actual high-risk factors (eg, smoking in LC, higher age in HF) by focusing on individual nutrients, but to examine the complex interaction of numerous factors involved in disease development. Because it warrants continued consideration, we also provide an update on neurotoxicity associated with vitamin B6. We consider that neurological side effects due to vitamin B6 intake are rare and only occur with high daily doses and/or longer treatment duration. The benefit-risk ratio of high-dose treatment with neurotropic B vitamins in indications like PN is therefore considered advantageous, particularly if dosing recommendations are followed and serum levels monitored.

UR - http://www.scopus.com/inward/record.url?scp=85098882973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85098882973&partnerID=8YFLogxK

U2 - 10.2147/TCRM.S274122

DO - 10.2147/TCRM.S274122

M3 - Review article

C2 - 33376337

AN - SCOPUS:85098882973

SN - 1176-6336

VL - 16

SP - 1275

EP - 1288

JO - Therapeutics and Clinical Risk Management

JF - Therapeutics and Clinical Risk Management

ER -

Update on safety profiles of vitamins B1, B6, and B12: A narrative review

Resumen

Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto