Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine

Adriana Janneth Bermudez Quintero, Manuel Elkin Patarroyo, Armando Moreno-Vranich

Resultado de la investigación: Contribución a RevistaArtículo

6 Citas (Scopus)

Resumen

If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by (1)H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria.
Idioma originalEnglish (US)
Páginas (desde-hasta)1057-1070
Número de páginas14
PublicaciónExpert Review of Vaccines
Volumen11
N.º9
EstadoPublished - ago 11 2012

Huella dactilar

Antimalarials
Plasmodium falciparum
Vaccines
Malaria Vaccines
Peptide T
Merozoites
Sporozoites
Peptides
Subunit Vaccines
Falciparum Malaria
T-Cell Antigen Receptor
Malaria
Erythrocytes
Liver
Proteins

Citar esto

Bermudez Quintero, A. J., Patarroyo, M. E., & Moreno-Vranich, A. (2012). Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine. Expert Review of Vaccines, 11(9), 1057-1070.
Bermudez Quintero, Adriana Janneth ; Patarroyo, Manuel Elkin ; Moreno-Vranich, Armando. / Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine. En: Expert Review of Vaccines. 2012 ; Vol. 11, N.º 9. pp. 1057-1070.
@article{b4abffc57c724745b0fe210224e33565,
title = "Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine",
abstract = "If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by (1)H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria.",
author = "{Bermudez Quintero}, {Adriana Janneth} and Patarroyo, {Manuel Elkin} and Armando Moreno-Vranich",
year = "2012",
month = "8",
day = "11",
language = "English (US)",
volume = "11",
pages = "1057--1070",
journal = "Expert Review of Vaccines",
issn = "1476-0584",
publisher = "Expert Reviews Ltd.",
number = "9",

}

Bermudez Quintero, AJ, Patarroyo, ME & Moreno-Vranich, A 2012, 'Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine', Expert Review of Vaccines, vol. 11, n.º 9, pp. 1057-1070.

Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine. / Bermudez Quintero, Adriana Janneth; Patarroyo, Manuel Elkin; Moreno-Vranich, Armando.

En: Expert Review of Vaccines, Vol. 11, N.º 9, 11.08.2012, p. 1057-1070.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine

AU - Bermudez Quintero, Adriana Janneth

AU - Patarroyo, Manuel Elkin

AU - Moreno-Vranich, Armando

PY - 2012/8/11

Y1 - 2012/8/11

N2 - If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by (1)H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria.

AB - If ever there were a truism then it would be that a completely protective Plasmodium falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts during the last 30 years to developing a fully protective, minimal subunit-based, multiepitope, multistage (targeting sporozoite and merozoite proteins), chemically synthesized antimalarial vaccine, given that peptides with high binding activity to their corresponding host cells (liver cells or red blood cells) form the springboard for vaccine design. However, such conserved high activity binding peptides have to be specifically modified to render them into highly immunogenic and protection-inducing peptides since they are immunologically silent. These modifications, analyzed at the 3D structural level by (1)H-NMR, allow them a better fit into the MHC II-peptide-T-cell receptor complex to induce an appropriate immune response, providing a rational and logical approach (analyzed at the single atom level) for vaccine development, particularly in the field of malaria.

M3 - Article

VL - 11

SP - 1057

EP - 1070

JO - Expert Review of Vaccines

JF - Expert Review of Vaccines

SN - 1476-0584

IS - 9

ER -

Bermudez Quintero AJ, Patarroyo ME, Moreno-Vranich A. Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine. Expert Review of Vaccines. 2012 ago 11;11(9):1057-1070.