THU0344 Osteoporosis and Vertebral Fractures in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

Nicolas Molano-Gonzalez, Mario García-Carrasco, Adriana Rojas-Villarraga, Pamela Soto Santillan , C Mendoza Pinto

Resultado de la investigación: Otra contribución

Resumen

Background Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VR) in patients with systemic lupus erythematosus (SLE). Objectives To evaluate the relationship between SLE and BMD, osteoporosis and the risk of vertebral fracture. Methods A systematic review and meta-regression analyses were carried out according to the Preferred Reporting Items for Systematic Meta-Analyses (PRISMA) guidelines. Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). The search was conducted using MesH terms, Boolean operators and keywords, which included “systemic lupus erythematosus”, “osteoporosis”, “bone mineral density”, and “vertebral fractures”. Prospective longitudinal and cross-sectional studies were considered for review without language restrictions. Articles were screened for suitability. Those selected were evaluated by two investigators, who extracted information on study characteristics, outcomes of interest, and risk of bias, and summarized the strength of evidence. Data was extracted when studies met inclusion criteria and were of sufficient quality. BMD, reported as the mean ± standard deviation evaluated by dual-energy X-ray absorptiometry (DXA), was analyzed including information on SLE cases and controls, treatment, menopausal status and fractures by meta-regression analysis adjusted by anatomical region. Data were analyzed using the Metafor package in R (3.0.2 version). Results In total 49 articles were identified and analyzed (12, 593 SLE cases/six anatomical regions and 14,235 controls/six anatomical regions). SLE women, but not SLE men, had a lower BMD than healthy controls (p<0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received corticosteroid (CTS) therapy. Unsurprisingly, postmenopausal SLE patients had a lower BMD (lumbar spine and total hip) compared with premenopausal patients (p<0.0001). The BMD did not differ in patients with and without fractures. Conclusions This systematic review and meta-regression analysis shows that women with SLE had a higher risk of low BMD than healthy controls. The data did not show that CTS therapy had an impact on BMD. • Bultink IE. Osteoporosis and fractures in systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012;64:2–8. Acknowledgement We would like to thank David Buss for his valuable guidance and advice during this project. Disclosure of Interest None declared THU0344 Osteoporosis and Vertebral Fractures in Patients with.... Available from: https://www.researchgate.net/publication/310777079_THU0344_Osteoporosis_and_Vertebral_Fractures_in_Patients_with_Systemic_Lupus_Erythematosus_A_Systematic_Review_and_Meta-Analysis [accessed May 03 2018].
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Volumen75
DOI
EstadoPublished - 2016

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Molano-Gonzalez, Nicolas ; García-Carrasco, Mario ; Rojas-Villarraga, Adriana ; Soto Santillan , Pamela ; Mendoza Pinto , C . / THU0344 Osteoporosis and Vertebral Fractures in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis. 2016. 2 p.
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title = "THU0344 Osteoporosis and Vertebral Fractures in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis",
abstract = "Background Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VR) in patients with systemic lupus erythematosus (SLE). Objectives To evaluate the relationship between SLE and BMD, osteoporosis and the risk of vertebral fracture. Methods A systematic review and meta-regression analyses were carried out according to the Preferred Reporting Items for Systematic Meta-Analyses (PRISMA) guidelines. Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). The search was conducted using MesH terms, Boolean operators and keywords, which included “systemic lupus erythematosus”, “osteoporosis”, “bone mineral density”, and “vertebral fractures”. Prospective longitudinal and cross-sectional studies were considered for review without language restrictions. Articles were screened for suitability. Those selected were evaluated by two investigators, who extracted information on study characteristics, outcomes of interest, and risk of bias, and summarized the strength of evidence. Data was extracted when studies met inclusion criteria and were of sufficient quality. BMD, reported as the mean ± standard deviation evaluated by dual-energy X-ray absorptiometry (DXA), was analyzed including information on SLE cases and controls, treatment, menopausal status and fractures by meta-regression analysis adjusted by anatomical region. Data were analyzed using the Metafor package in R (3.0.2 version). Results In total 49 articles were identified and analyzed (12, 593 SLE cases/six anatomical regions and 14,235 controls/six anatomical regions). SLE women, but not SLE men, had a lower BMD than healthy controls (p<0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received corticosteroid (CTS) therapy. Unsurprisingly, postmenopausal SLE patients had a lower BMD (lumbar spine and total hip) compared with premenopausal patients (p<0.0001). The BMD did not differ in patients with and without fractures. Conclusions This systematic review and meta-regression analysis shows that women with SLE had a higher risk of low BMD than healthy controls. The data did not show that CTS therapy had an impact on BMD. • Bultink IE. Osteoporosis and fractures in systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012;64:2–8. Acknowledgement We would like to thank David Buss for his valuable guidance and advice during this project. Disclosure of Interest None declared THU0344 Osteoporosis and Vertebral Fractures in Patients with.... Available from: https://www.researchgate.net/publication/310777079_THU0344_Osteoporosis_and_Vertebral_Fractures_in_Patients_with_Systemic_Lupus_Erythematosus_A_Systematic_Review_and_Meta-Analysis [accessed May 03 2018].",
author = "Nicolas Molano-Gonzalez and Mario Garc{\'i}a-Carrasco and Adriana Rojas-Villarraga and {Soto Santillan}, Pamela and {Mendoza Pinto}, C",
year = "2016",
doi = "http://dx.doi.org/10.1136/annrheumdis-2016-eular.2267",
language = "Indefinido/desconocido",
volume = "75",
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THU0344 Osteoporosis and Vertebral Fractures in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis. / Molano-Gonzalez, Nicolas; García-Carrasco, Mario; Rojas-Villarraga, Adriana; Soto Santillan , Pamela ; Mendoza Pinto , C .

2 p. 2016, .

Resultado de la investigación: Otra contribución

TY - GEN

T1 - THU0344 Osteoporosis and Vertebral Fractures in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

AU - Molano-Gonzalez, Nicolas

AU - García-Carrasco, Mario

AU - Rojas-Villarraga, Adriana

AU - Soto Santillan , Pamela

AU - Mendoza Pinto , C

PY - 2016

Y1 - 2016

N2 - Background Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VR) in patients with systemic lupus erythematosus (SLE). Objectives To evaluate the relationship between SLE and BMD, osteoporosis and the risk of vertebral fracture. Methods A systematic review and meta-regression analyses were carried out according to the Preferred Reporting Items for Systematic Meta-Analyses (PRISMA) guidelines. Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). The search was conducted using MesH terms, Boolean operators and keywords, which included “systemic lupus erythematosus”, “osteoporosis”, “bone mineral density”, and “vertebral fractures”. Prospective longitudinal and cross-sectional studies were considered for review without language restrictions. Articles were screened for suitability. Those selected were evaluated by two investigators, who extracted information on study characteristics, outcomes of interest, and risk of bias, and summarized the strength of evidence. Data was extracted when studies met inclusion criteria and were of sufficient quality. BMD, reported as the mean ± standard deviation evaluated by dual-energy X-ray absorptiometry (DXA), was analyzed including information on SLE cases and controls, treatment, menopausal status and fractures by meta-regression analysis adjusted by anatomical region. Data were analyzed using the Metafor package in R (3.0.2 version). Results In total 49 articles were identified and analyzed (12, 593 SLE cases/six anatomical regions and 14,235 controls/six anatomical regions). SLE women, but not SLE men, had a lower BMD than healthy controls (p<0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received corticosteroid (CTS) therapy. Unsurprisingly, postmenopausal SLE patients had a lower BMD (lumbar spine and total hip) compared with premenopausal patients (p<0.0001). The BMD did not differ in patients with and without fractures. Conclusions This systematic review and meta-regression analysis shows that women with SLE had a higher risk of low BMD than healthy controls. The data did not show that CTS therapy had an impact on BMD. • Bultink IE. Osteoporosis and fractures in systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012;64:2–8. Acknowledgement We would like to thank David Buss for his valuable guidance and advice during this project. Disclosure of Interest None declared THU0344 Osteoporosis and Vertebral Fractures in Patients with.... Available from: https://www.researchgate.net/publication/310777079_THU0344_Osteoporosis_and_Vertebral_Fractures_in_Patients_with_Systemic_Lupus_Erythematosus_A_Systematic_Review_and_Meta-Analysis [accessed May 03 2018].

AB - Background Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VR) in patients with systemic lupus erythematosus (SLE). Objectives To evaluate the relationship between SLE and BMD, osteoporosis and the risk of vertebral fracture. Methods A systematic review and meta-regression analyses were carried out according to the Preferred Reporting Items for Systematic Meta-Analyses (PRISMA) guidelines. Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). The search was conducted using MesH terms, Boolean operators and keywords, which included “systemic lupus erythematosus”, “osteoporosis”, “bone mineral density”, and “vertebral fractures”. Prospective longitudinal and cross-sectional studies were considered for review without language restrictions. Articles were screened for suitability. Those selected were evaluated by two investigators, who extracted information on study characteristics, outcomes of interest, and risk of bias, and summarized the strength of evidence. Data was extracted when studies met inclusion criteria and were of sufficient quality. BMD, reported as the mean ± standard deviation evaluated by dual-energy X-ray absorptiometry (DXA), was analyzed including information on SLE cases and controls, treatment, menopausal status and fractures by meta-regression analysis adjusted by anatomical region. Data were analyzed using the Metafor package in R (3.0.2 version). Results In total 49 articles were identified and analyzed (12, 593 SLE cases/six anatomical regions and 14,235 controls/six anatomical regions). SLE women, but not SLE men, had a lower BMD than healthy controls (p<0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received corticosteroid (CTS) therapy. Unsurprisingly, postmenopausal SLE patients had a lower BMD (lumbar spine and total hip) compared with premenopausal patients (p<0.0001). The BMD did not differ in patients with and without fractures. Conclusions This systematic review and meta-regression analysis shows that women with SLE had a higher risk of low BMD than healthy controls. The data did not show that CTS therapy had an impact on BMD. • Bultink IE. Osteoporosis and fractures in systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012;64:2–8. Acknowledgement We would like to thank David Buss for his valuable guidance and advice during this project. Disclosure of Interest None declared THU0344 Osteoporosis and Vertebral Fractures in Patients with.... Available from: https://www.researchgate.net/publication/310777079_THU0344_Osteoporosis_and_Vertebral_Fractures_in_Patients_with_Systemic_Lupus_Erythematosus_A_Systematic_Review_and_Meta-Analysis [accessed May 03 2018].

U2 - http://dx.doi.org/10.1136/annrheumdis-2016-eular.2267

DO - http://dx.doi.org/10.1136/annrheumdis-2016-eular.2267

M3 - Otra contribución

VL - 75

ER -