Thermodynamic Analysis of the Solubility of Isoniazid in (PEG 200 +Water) Cosolvent Mixtures from 278.15 K to 318.15 K

Carlos Alberto Calderon Ospina

doi:10.3390/ijms231710190

Thermodynamic Analysis of the Solubility of Isoniazid in (PEG 200 +Water) Cosolvent Mixtures from 278.15 K to 318.15 K

Título traducido de la contribución: Análisis termodinámico de la solubilidad de la isoniacida en mezclas de cosolvente (PEG 200 + agua) desde 278.15 K hasta 318.15 K

Carlos Alberto Calderon Ospina

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

6 Citas (Scopus)

Resumen

La solubilidad de los medicamentos en sistemas de cosolventes de interés farmacéutico es de gran importancia para entender y optimizar una gran cantidad de procesos. Aquí, reportamos la solubilidad de la isoniacida en nueve mezclas de cosolvente (PEG 200 + agua) a nueve temperaturas (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15 y 318.15 K), determinada mediante espectrofotometría UV-vis. A partir de los datos de solubilidad, se calcularon las funciones termodinámicas de solución, mezcla y transferencia, además de realizar el análisis de compensación entalpía-entropía. La solubilidad de la isoniacida depende de la concentración de PEG 200 (efecto cosolvente positivo) y de la temperatura (proceso endotérmico), alcanzando su máxima solubilidad en PEG 200 puro a 318.15 K y la menor solubilidad en agua pura a 278.15 K. El proceso de solución se ve favorecido por la entropía de la solución y, según el análisis de compensación entalpía-entropía, está impulsado por la entropía en las mezclas ricas en agua y por la entalpía en las mezclas ricas en PEG 200

Título traducido de la contribución	Análisis termodinámico de la solubilidad de la isoniacida en mezclas de cosolvente (PEG 200 + agua) desde 278.15 K hasta 318.15 K
Idioma original	Inglés estadounidense
Número de artículo	10190
Publicación	International Journal of Molecular Sciences
Volumen	23
N.º	17
DOI	https://doi.org/10.3390/ijms231710190
Estado	Publicada - sep. 5 2022

Áreas temáticas de ASJC Scopus

Biología molecular
Espectroscopia
Catálisis
Química inorgánica
Informática aplicada
Química física y teórica
Química orgánica

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@article{54b4ea8a22574904b0d00425a5a0afe8,

title = "Thermodynamic Analysis of the Solubility of Isoniazid in (PEG 200 +Water) Cosolvent Mixtures from 278.15 K to 318.15 K",

abstract = "The solubility of drugs in cosolvent systems of pharmaceutical interest is of great importance for understanding and optimizing a large number of processes. Here, we report the solubility of isoniazid in nine (PEG 200 + water) cosolvent mixtures at nine temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, and 318.15 K) determined by UV–vis spectrophotometry. From the solubility data, the thermodynamic solution, mixing, and transfer functions were calculated in addition to performing the enthalpy–entropy compensation analysis. The solubility of isoniazid depends on the concentration of PEG 200 (positive cosolvent effect) and temperature (endothermic process) reaching its maximum solubility in pure PEG 200 at 318.15 K and the lowest solubility in pure water at 278.15 K. The solution process is favored by the solution entropy and according to the enthalpy–entropy compensation analysis it is driven by entropy in mixtures rich in water and by enthalpy in mixtures rich in PEG 200.",

author = "{Calderon Ospina}, {Carlos Alberto}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

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T1 - Thermodynamic Analysis of the Solubility of Isoniazid in (PEG 200 +Water) Cosolvent Mixtures from 278.15 K to 318.15 K

AU - Calderon Ospina, Carlos Alberto

PY - 2022/9/5

Y1 - 2022/9/5

N2 - The solubility of drugs in cosolvent systems of pharmaceutical interest is of great importance for understanding and optimizing a large number of processes. Here, we report the solubility of isoniazid in nine (PEG 200 + water) cosolvent mixtures at nine temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, and 318.15 K) determined by UV–vis spectrophotometry. From the solubility data, the thermodynamic solution, mixing, and transfer functions were calculated in addition to performing the enthalpy–entropy compensation analysis. The solubility of isoniazid depends on the concentration of PEG 200 (positive cosolvent effect) and temperature (endothermic process) reaching its maximum solubility in pure PEG 200 at 318.15 K and the lowest solubility in pure water at 278.15 K. The solution process is favored by the solution entropy and according to the enthalpy–entropy compensation analysis it is driven by entropy in mixtures rich in water and by enthalpy in mixtures rich in PEG 200.

AB - The solubility of drugs in cosolvent systems of pharmaceutical interest is of great importance for understanding and optimizing a large number of processes. Here, we report the solubility of isoniazid in nine (PEG 200 + water) cosolvent mixtures at nine temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, and 318.15 K) determined by UV–vis spectrophotometry. From the solubility data, the thermodynamic solution, mixing, and transfer functions were calculated in addition to performing the enthalpy–entropy compensation analysis. The solubility of isoniazid depends on the concentration of PEG 200 (positive cosolvent effect) and temperature (endothermic process) reaching its maximum solubility in pure PEG 200 at 318.15 K and the lowest solubility in pure water at 278.15 K. The solution process is favored by the solution entropy and according to the enthalpy–entropy compensation analysis it is driven by entropy in mixtures rich in water and by enthalpy in mixtures rich in PEG 200.

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U2 - 10.3390/ijms231710190

DO - 10.3390/ijms231710190

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SN - 1661-6596

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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Thermodynamic Analysis of the Solubility of Isoniazid in (PEG 200 +Water) Cosolvent Mixtures from 278.15 K to 318.15 K

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