The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac disease

Alejandra Claudia Cherñavsky, María Carolina Páez, Natalia Periolo, Paula Correa, Laura Guillén, Sonia Isabel Niveloni, Eduardo Mauriño, Julio César Bai, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

6 Citas (Scopus)

Resumen

To assess the joint contribution of interleukin 1 beta (IL-1B) and tumor necrosis factor alpha (TNFα) to the genetic risk of developing celiac disease (CD), we analyzed four biallelic polymorphisms of TNFA and IL-1B genes in 228 patients and 244 healthy controls. The individual contribution of TNFA -308A and IL-1B -511C alleles was weak (OR 1.47 and 1.66, respectively) and was null for TNFA -238 A/G and IL-1B +3953 C/T single nucleotide polymorphisms (SNPs). Due to the potential linkage disequilibrium between TNFA, human leukocyte antigen (HLA) -DQA1 and HLA-DQB1 genes, only individuals carrying DQ2 antigen (DQ2-positive) were considered to perform haplotype analyses. Two-position risk haplotypes were first defined by the combined presence of -511C and +3953T alleles for IL-1B (OR 9.402) or -308A and -238A alleles for TNFA (OR 15.389). The TNFA/IL-1B combined haplotype-stratified association analysis showed that the simultaneous presence of TNFA risk and IL-1B non-risk haplotypes (OR 13.32) but not TNFA non-risk and IL-1B risk haplotypes (OR 0.71) is associated with CD. Interestingly, our data suggest that the coexistence of both risk haplotypes seems to work synergistically (OR 29.59), which enhances the risk of developing CD. © 2008 Elsevier Ltd. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)48-54
Número de páginas7
PublicaciónCytokine
DOI
EstadoPublished - abr 1 2008

Huella dactilar

Celiac Disease
Interleukin-1beta
Haplotypes
Alleles
HLA Antigens
Polymorphism
Genes
Linkage Disequilibrium
Single Nucleotide Polymorphism
Nucleotides
Tumor Necrosis Factor-alpha
Antigens

Citar esto

Cherñavsky, Alejandra Claudia ; Páez, María Carolina ; Periolo, Natalia ; Correa, Paula ; Guillén, Laura ; Niveloni, Sonia Isabel ; Mauriño, Eduardo ; Bai, Julio César ; Anaya, Juan Manuel. / The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac disease. En: Cytokine. 2008 ; pp. 48-54.
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title = "The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac disease",
abstract = "To assess the joint contribution of interleukin 1 beta (IL-1B) and tumor necrosis factor alpha (TNFα) to the genetic risk of developing celiac disease (CD), we analyzed four biallelic polymorphisms of TNFA and IL-1B genes in 228 patients and 244 healthy controls. The individual contribution of TNFA -308A and IL-1B -511C alleles was weak (OR 1.47 and 1.66, respectively) and was null for TNFA -238 A/G and IL-1B +3953 C/T single nucleotide polymorphisms (SNPs). Due to the potential linkage disequilibrium between TNFA, human leukocyte antigen (HLA) -DQA1 and HLA-DQB1 genes, only individuals carrying DQ2 antigen (DQ2-positive) were considered to perform haplotype analyses. Two-position risk haplotypes were first defined by the combined presence of -511C and +3953T alleles for IL-1B (OR 9.402) or -308A and -238A alleles for TNFA (OR 15.389). The TNFA/IL-1B combined haplotype-stratified association analysis showed that the simultaneous presence of TNFA risk and IL-1B non-risk haplotypes (OR 13.32) but not TNFA non-risk and IL-1B risk haplotypes (OR 0.71) is associated with CD. Interestingly, our data suggest that the coexistence of both risk haplotypes seems to work synergistically (OR 29.59), which enhances the risk of developing CD. {\circledC} 2008 Elsevier Ltd. All rights reserved.",
author = "Cher{\~n}avsky, {Alejandra Claudia} and P{\'a}ez, {Mar{\'i}a Carolina} and Natalia Periolo and Paula Correa and Laura Guill{\'e}n and Niveloni, {Sonia Isabel} and Eduardo Mauri{\~n}o and Bai, {Julio C{\'e}sar} and Anaya, {Juan Manuel}",
year = "2008",
month = "4",
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doi = "10.1016/j.cyto.2008.01.015",
language = "English (US)",
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Cherñavsky, AC, Páez, MC, Periolo, N, Correa, P, Guillén, L, Niveloni, SI, Mauriño, E, Bai, JC & Anaya, JM 2008, 'The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac disease', Cytokine, pp. 48-54. https://doi.org/10.1016/j.cyto.2008.01.015

The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac disease. / Cherñavsky, Alejandra Claudia; Páez, María Carolina; Periolo, Natalia; Correa, Paula; Guillén, Laura; Niveloni, Sonia Isabel; Mauriño, Eduardo; Bai, Julio César; Anaya, Juan Manuel.

En: Cytokine, 01.04.2008, p. 48-54.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - The simultaneous presence of IL-1B and TNFA two-positions risk haplotypes enhances the susceptibility for celiac disease

AU - Cherñavsky, Alejandra Claudia

AU - Páez, María Carolina

AU - Periolo, Natalia

AU - Correa, Paula

AU - Guillén, Laura

AU - Niveloni, Sonia Isabel

AU - Mauriño, Eduardo

AU - Bai, Julio César

AU - Anaya, Juan Manuel

PY - 2008/4/1

Y1 - 2008/4/1

N2 - To assess the joint contribution of interleukin 1 beta (IL-1B) and tumor necrosis factor alpha (TNFα) to the genetic risk of developing celiac disease (CD), we analyzed four biallelic polymorphisms of TNFA and IL-1B genes in 228 patients and 244 healthy controls. The individual contribution of TNFA -308A and IL-1B -511C alleles was weak (OR 1.47 and 1.66, respectively) and was null for TNFA -238 A/G and IL-1B +3953 C/T single nucleotide polymorphisms (SNPs). Due to the potential linkage disequilibrium between TNFA, human leukocyte antigen (HLA) -DQA1 and HLA-DQB1 genes, only individuals carrying DQ2 antigen (DQ2-positive) were considered to perform haplotype analyses. Two-position risk haplotypes were first defined by the combined presence of -511C and +3953T alleles for IL-1B (OR 9.402) or -308A and -238A alleles for TNFA (OR 15.389). The TNFA/IL-1B combined haplotype-stratified association analysis showed that the simultaneous presence of TNFA risk and IL-1B non-risk haplotypes (OR 13.32) but not TNFA non-risk and IL-1B risk haplotypes (OR 0.71) is associated with CD. Interestingly, our data suggest that the coexistence of both risk haplotypes seems to work synergistically (OR 29.59), which enhances the risk of developing CD. © 2008 Elsevier Ltd. All rights reserved.

AB - To assess the joint contribution of interleukin 1 beta (IL-1B) and tumor necrosis factor alpha (TNFα) to the genetic risk of developing celiac disease (CD), we analyzed four biallelic polymorphisms of TNFA and IL-1B genes in 228 patients and 244 healthy controls. The individual contribution of TNFA -308A and IL-1B -511C alleles was weak (OR 1.47 and 1.66, respectively) and was null for TNFA -238 A/G and IL-1B +3953 C/T single nucleotide polymorphisms (SNPs). Due to the potential linkage disequilibrium between TNFA, human leukocyte antigen (HLA) -DQA1 and HLA-DQB1 genes, only individuals carrying DQ2 antigen (DQ2-positive) were considered to perform haplotype analyses. Two-position risk haplotypes were first defined by the combined presence of -511C and +3953T alleles for IL-1B (OR 9.402) or -308A and -238A alleles for TNFA (OR 15.389). The TNFA/IL-1B combined haplotype-stratified association analysis showed that the simultaneous presence of TNFA risk and IL-1B non-risk haplotypes (OR 13.32) but not TNFA non-risk and IL-1B risk haplotypes (OR 0.71) is associated with CD. Interestingly, our data suggest that the coexistence of both risk haplotypes seems to work synergistically (OR 29.59), which enhances the risk of developing CD. © 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.cyto.2008.01.015

DO - 10.1016/j.cyto.2008.01.015

M3 - Article

SP - 48

EP - 54

JO - Cytokine

JF - Cytokine

SN - 1043-4666

ER -