The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development

César Reyes, Armando Moreno-Vranich, Manuel Elkin Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

4 Citas (Scopus)

Resumen

Analysis of our Plasmodium falciparum malaria parasite peptides’ 1H-NMR database in the search for H-bonds and π-interactions led us to correlate their presence or absence with a peptide's particular immunological behavior. It was concluded that a 26.5 ± 1.5 Å between positions 1 to 9 of the HLA-DRβ1* interacting region was necessary for proper docking of 20mer-long peptides and these MHC Class II molecules for full-protective immunity. Presence of intramolecular H-bonds or π-interactions leading to righ-handed α-helix or β-turn conformation in this peptide's region induces different immune responses or none. PPIIL conformation and the absence of any intramolecular interaction thus became the first feature characterising our immune protection-inducing structures as malaria vaccine candidates.

Idioma originalEnglish (US)
Páginas (desde-hasta)501-507
Número de páginas7
PublicaciónBiochemical and Biophysical Research Communications
Volumen484
N.º3
DOI
EstadoPublished - mar 11 2017
Publicado de forma externa

Huella dactilar

Malaria Vaccines
Synthetic Vaccines
Hydrogen
Hydrogen bonds
Peptides
Conformations
Falciparum Malaria
Immunity
Parasites
Nuclear magnetic resonance
Databases
Molecules

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Citar esto

Reyes, César ; Moreno-Vranich, Armando ; Patarroyo, Manuel Elkin. / The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development. En: Biochemical and Biophysical Research Communications. 2017 ; Vol. 484, N.º 3. pp. 501-507.
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The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development. / Reyes, César; Moreno-Vranich, Armando; Patarroyo, Manuel Elkin.

En: Biochemical and Biophysical Research Communications, Vol. 484, N.º 3, 11.03.2017, p. 501-507.

Resultado de la investigación: Contribución a RevistaArtículo

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