The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents

Luisa Del Río-Ospina, Sara Cecilia Soto De León, Milena Camargo, Ricardo Sánchez, Cindy Lizeth Mancilla, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

4 Citas (Scopus)

Resumen

© 2016 Del Río-Ospina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and typespecific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01-2.71 95%CI), white ethnicity (4.40: 1.16-16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.
Idioma originalEnglish (US)
PublicaciónPLoS One
DOI
EstadoPublished - nov 1 2016

Huella dactilar

Infection
infection
Human papillomavirus 16
sexually transmitted diseases
Andes region
Viral DNA
United States Public Health Service
Public health
Sexual Partners
DNA
sexual behavior
Regression analysis
Licensure
Sexually Transmitted Diseases
nationalities and ethnic groups
Coinfection
mixed infection
Sexual Behavior
health services
Reproduction

Citar esto

Río-Ospina, Luisa Del ; León, Sara Cecilia Soto De ; Camargo, Milena ; Sánchez, Ricardo ; Mancilla, Cindy Lizeth ; Patarroyo, Manuel Elkin ; Patarroyo, Manuel Alfonso. / The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents. En: PLoS One. 2016.
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title = "The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents",
abstract = "{\circledC} 2016 Del R{\'i}o-Ospina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and typespecific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97{\%} of the females; 28.52{\%} of them had multiple infections, HPV-16 being the most frequently occurring type (37.44{\%}). Cytological abnormality prevalence was 15.61{\%}. Being over 16 years-old (1.66: 1.01-2.71 95{\%}CI), white ethnicity (4.40: 1.16-16.73 95{\%}CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95{\%}CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95{\%}CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95{\%}CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.",
author = "R{\'i}o-Ospina, {Luisa Del} and Le{\'o}n, {Sara Cecilia Soto De} and Milena Camargo and Ricardo S{\'a}nchez and Mancilla, {Cindy Lizeth} and Patarroyo, {Manuel Elkin} and Patarroyo, {Manuel Alfonso}",
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The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents. / Río-Ospina, Luisa Del; León, Sara Cecilia Soto De; Camargo, Milena; Sánchez, Ricardo; Mancilla, Cindy Lizeth; Patarroyo, Manuel Elkin; Patarroyo, Manuel Alfonso.

En: PLoS One, 01.11.2016.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents

AU - Río-Ospina, Luisa Del

AU - León, Sara Cecilia Soto De

AU - Camargo, Milena

AU - Sánchez, Ricardo

AU - Mancilla, Cindy Lizeth

AU - Patarroyo, Manuel Elkin

AU - Patarroyo, Manuel Alfonso

PY - 2016/11/1

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N2 - © 2016 Del Río-Ospina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and typespecific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01-2.71 95%CI), white ethnicity (4.40: 1.16-16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.

AB - © 2016 Del Río-Ospina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and typespecific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01-2.71 95%CI), white ethnicity (4.40: 1.16-16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.

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DO - 10.1371/journal.pone.0166502

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