The Plasmodium vivax Pv41 surface protein: Identification and characterization

Diana I. Angel, Alvaro Mongui, Javier Ardila, Magnolia Vanegas, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

17 Citas (Scopus)

Resumen

Recently, Plasmodium vivax has been related to nearly 81% of malaria cases reported in Central America and the Mediterranean. Due to the difficulty of culturing this parasite species in vitro, most studies on P. vivax have focused on the identification of new antigens by homology comparison with P. falciparum vaccine candidate proteins. In this study, we have identified and characterized a Pf41 homologue in P. vivax, hence named Pv41, by following such approach and using web-available bioinformatics databases, molecular techniques and immunochemistry assays. Pv41 protein is a 384-amino-acid-long antigen encoded by a single exon that exhibits two s48/45 domains characteristic of gametocyte surface proteins. We have also demonstrated Pv41 transcription and expression during late intra-erythrocytic parasite stages and defined its subcellular localization on the parasite surface. © 2008 Elsevier Inc. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)1113-1117
Número de páginas5
PublicaciónBiochemical and Biophysical Research Communications
DOI
EstadoPublished - dic 26 2008

Huella dactilar

Plasmodium vivax
Membrane Proteins
Parasites
Chemical Databases
Immunochemistry
Antigens
Central America
Transcription
Bioinformatics
Computational Biology
Malaria
Exons
Assays
Proteins
Vaccines
Amino Acids

Citar esto

@article{9efc68bb05d44f80bdebe2ef555035a8,
title = "The Plasmodium vivax Pv41 surface protein: Identification and characterization",
abstract = "Recently, Plasmodium vivax has been related to nearly 81{\%} of malaria cases reported in Central America and the Mediterranean. Due to the difficulty of culturing this parasite species in vitro, most studies on P. vivax have focused on the identification of new antigens by homology comparison with P. falciparum vaccine candidate proteins. In this study, we have identified and characterized a Pf41 homologue in P. vivax, hence named Pv41, by following such approach and using web-available bioinformatics databases, molecular techniques and immunochemistry assays. Pv41 protein is a 384-amino-acid-long antigen encoded by a single exon that exhibits two s48/45 domains characteristic of gametocyte surface proteins. We have also demonstrated Pv41 transcription and expression during late intra-erythrocytic parasite stages and defined its subcellular localization on the parasite surface. {\circledC} 2008 Elsevier Inc. All rights reserved.",
author = "Angel, {Diana I.} and Alvaro Mongui and Javier Ardila and Magnolia Vanegas and Patarroyo, {Manuel A.}",
year = "2008",
month = "12",
day = "26",
doi = "10.1016/j.bbrc.2008.10.129",
language = "English (US)",
pages = "1113--1117",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",

}

The Plasmodium vivax Pv41 surface protein: Identification and characterization. / Angel, Diana I.; Mongui, Alvaro; Ardila, Javier; Vanegas, Magnolia; Patarroyo, Manuel A.

En: Biochemical and Biophysical Research Communications, 26.12.2008, p. 1113-1117.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - The Plasmodium vivax Pv41 surface protein: Identification and characterization

AU - Angel, Diana I.

AU - Mongui, Alvaro

AU - Ardila, Javier

AU - Vanegas, Magnolia

AU - Patarroyo, Manuel A.

PY - 2008/12/26

Y1 - 2008/12/26

N2 - Recently, Plasmodium vivax has been related to nearly 81% of malaria cases reported in Central America and the Mediterranean. Due to the difficulty of culturing this parasite species in vitro, most studies on P. vivax have focused on the identification of new antigens by homology comparison with P. falciparum vaccine candidate proteins. In this study, we have identified and characterized a Pf41 homologue in P. vivax, hence named Pv41, by following such approach and using web-available bioinformatics databases, molecular techniques and immunochemistry assays. Pv41 protein is a 384-amino-acid-long antigen encoded by a single exon that exhibits two s48/45 domains characteristic of gametocyte surface proteins. We have also demonstrated Pv41 transcription and expression during late intra-erythrocytic parasite stages and defined its subcellular localization on the parasite surface. © 2008 Elsevier Inc. All rights reserved.

AB - Recently, Plasmodium vivax has been related to nearly 81% of malaria cases reported in Central America and the Mediterranean. Due to the difficulty of culturing this parasite species in vitro, most studies on P. vivax have focused on the identification of new antigens by homology comparison with P. falciparum vaccine candidate proteins. In this study, we have identified and characterized a Pf41 homologue in P. vivax, hence named Pv41, by following such approach and using web-available bioinformatics databases, molecular techniques and immunochemistry assays. Pv41 protein is a 384-amino-acid-long antigen encoded by a single exon that exhibits two s48/45 domains characteristic of gametocyte surface proteins. We have also demonstrated Pv41 transcription and expression during late intra-erythrocytic parasite stages and defined its subcellular localization on the parasite surface. © 2008 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.bbrc.2008.10.129

DO - 10.1016/j.bbrc.2008.10.129

M3 - Article

C2 - 18983983

SP - 1113

EP - 1117

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

ER -