The PHF21B gene is associated with major depression and modulates the stress response

M.-L. Wong, M. Arcos-Burgos, S. Liu, J.I. Vélez, C. Yu, B.T. Baune, M.C. Jawahar, V. Arolt, U. Dannlowski, A. Chuah, G.A. Huttley, R. Fogarty, M.D. Lewis, S.R. Bornstein, J. Licinio

Resultado de la investigación: Contribución a RevistaArtículo

17 Citas (Scopus)

Resumen

Major depressive disorder (MDD) affects around 350 million people worldwide; however, the underlying genetic basis remains largely unknown. In this study, we took into account that MDD is a gene-environment disorder, in which stress is a critical component, and used whole-genome screening of functional variants to investigate the â missing heritability' in MDD. Genome-wide association studies (GWAS) using single- A nd multi-locus linear mixed-effect models were performed in a Los Angeles Mexican-American cohort (196 controls, 203 MDD) and in a replication European-ancestry cohort (499 controls, 473 MDD). Our analyses took into consideration the stress levels in the control populations. The Mexican-American controls, comprised primarily of recent immigrants, had high levels of stress due to acculturation issues and the European-ancestry controls with high stress levels were given higher weights in our analysis. We identified 44 common and rare functional variants associated with mild to moderate MDD in the Mexican-American cohort (genome-wide false discovery rate, FDR,
Idioma originalEnglish (US)
Páginas (desde-hasta)1015-1025
Número de páginas11
PublicaciónMolecular Psychiatry
Volumen22
N.º7
DOI
EstadoPublished - 2017

Huella dactilar

Major Depressive Disorder
Depression
Genes
Genome
Acculturation
Los Angeles
Genome-Wide Association Study
Weights and Measures
Population

Citar esto

Wong, M-L., Arcos-Burgos, M., Liu, S., Vélez, J. I., Yu, C., Baune, B. T., ... Licinio, J. (2017). The PHF21B gene is associated with major depression and modulates the stress response. Molecular Psychiatry, 22(7), 1015-1025. https://doi.org/10.1038/mp.2016.174
Wong, M.-L. ; Arcos-Burgos, M. ; Liu, S. ; Vélez, J.I. ; Yu, C. ; Baune, B.T. ; Jawahar, M.C. ; Arolt, V. ; Dannlowski, U. ; Chuah, A. ; Huttley, G.A. ; Fogarty, R. ; Lewis, M.D. ; Bornstein, S.R. ; Licinio, J. / The PHF21B gene is associated with major depression and modulates the stress response. En: Molecular Psychiatry. 2017 ; Vol. 22, N.º 7. pp. 1015-1025.
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abstract = "Major depressive disorder (MDD) affects around 350 million people worldwide; however, the underlying genetic basis remains largely unknown. In this study, we took into account that MDD is a gene-environment disorder, in which stress is a critical component, and used whole-genome screening of functional variants to investigate the {\^a} missing heritability' in MDD. Genome-wide association studies (GWAS) using single- A nd multi-locus linear mixed-effect models were performed in a Los Angeles Mexican-American cohort (196 controls, 203 MDD) and in a replication European-ancestry cohort (499 controls, 473 MDD). Our analyses took into consideration the stress levels in the control populations. The Mexican-American controls, comprised primarily of recent immigrants, had high levels of stress due to acculturation issues and the European-ancestry controls with high stress levels were given higher weights in our analysis. We identified 44 common and rare functional variants associated with mild to moderate MDD in the Mexican-American cohort (genome-wide false discovery rate, FDR,",
author = "M.-L. Wong and M. Arcos-Burgos and S. Liu and J.I. V{\'e}lez and C. Yu and B.T. Baune and M.C. Jawahar and V. Arolt and U. Dannlowski and A. Chuah and G.A. Huttley and R. Fogarty and M.D. Lewis and S.R. Bornstein and J. Licinio",
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Wong, M-L, Arcos-Burgos, M, Liu, S, Vélez, JI, Yu, C, Baune, BT, Jawahar, MC, Arolt, V, Dannlowski, U, Chuah, A, Huttley, GA, Fogarty, R, Lewis, MD, Bornstein, SR & Licinio, J 2017, 'The PHF21B gene is associated with major depression and modulates the stress response', Molecular Psychiatry, vol. 22, n.º 7, pp. 1015-1025. https://doi.org/10.1038/mp.2016.174

The PHF21B gene is associated with major depression and modulates the stress response. / Wong, M.-L.; Arcos-Burgos, M.; Liu, S.; Vélez, J.I.; Yu, C.; Baune, B.T.; Jawahar, M.C.; Arolt, V.; Dannlowski, U.; Chuah, A.; Huttley, G.A.; Fogarty, R.; Lewis, M.D.; Bornstein, S.R.; Licinio, J.

En: Molecular Psychiatry, Vol. 22, N.º 7, 2017, p. 1015-1025.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - The PHF21B gene is associated with major depression and modulates the stress response

AU - Wong, M.-L.

AU - Arcos-Burgos, M.

AU - Liu, S.

AU - Vélez, J.I.

AU - Yu, C.

AU - Baune, B.T.

AU - Jawahar, M.C.

AU - Arolt, V.

AU - Dannlowski, U.

AU - Chuah, A.

AU - Huttley, G.A.

AU - Fogarty, R.

AU - Lewis, M.D.

AU - Bornstein, S.R.

AU - Licinio, J.

N1 - Cited By :6 Export Date: 4 April 2018 CODEN: MOPSF

PY - 2017

Y1 - 2017

N2 - Major depressive disorder (MDD) affects around 350 million people worldwide; however, the underlying genetic basis remains largely unknown. In this study, we took into account that MDD is a gene-environment disorder, in which stress is a critical component, and used whole-genome screening of functional variants to investigate the â missing heritability' in MDD. Genome-wide association studies (GWAS) using single- A nd multi-locus linear mixed-effect models were performed in a Los Angeles Mexican-American cohort (196 controls, 203 MDD) and in a replication European-ancestry cohort (499 controls, 473 MDD). Our analyses took into consideration the stress levels in the control populations. The Mexican-American controls, comprised primarily of recent immigrants, had high levels of stress due to acculturation issues and the European-ancestry controls with high stress levels were given higher weights in our analysis. We identified 44 common and rare functional variants associated with mild to moderate MDD in the Mexican-American cohort (genome-wide false discovery rate, FDR,

AB - Major depressive disorder (MDD) affects around 350 million people worldwide; however, the underlying genetic basis remains largely unknown. In this study, we took into account that MDD is a gene-environment disorder, in which stress is a critical component, and used whole-genome screening of functional variants to investigate the â missing heritability' in MDD. Genome-wide association studies (GWAS) using single- A nd multi-locus linear mixed-effect models were performed in a Los Angeles Mexican-American cohort (196 controls, 203 MDD) and in a replication European-ancestry cohort (499 controls, 473 MDD). Our analyses took into consideration the stress levels in the control populations. The Mexican-American controls, comprised primarily of recent immigrants, had high levels of stress due to acculturation issues and the European-ancestry controls with high stress levels were given higher weights in our analysis. We identified 44 common and rare functional variants associated with mild to moderate MDD in the Mexican-American cohort (genome-wide false discovery rate, FDR,

U2 - 10.1038/mp.2016.174

DO - 10.1038/mp.2016.174

M3 - Article

C2 - 27777418

VL - 22

SP - 1015

EP - 1025

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 7

ER -

Wong M-L, Arcos-Burgos M, Liu S, Vélez JI, Yu C, Baune BT y otros. The PHF21B gene is associated with major depression and modulates the stress response. Molecular Psychiatry. 2017;22(7):1015-1025. https://doi.org/10.1038/mp.2016.174