The multiple autoimmune syndromes. A clue for the autoimmune tautology

Juan Manuel Anaya, John Castiblanco, Adriana Rojas-Villarraga, Ricardo Pineda-Tamayo, Roger A. Levy, José Gómez-Puerta, Carlos Dias, Ruben D. Mantilla, Juan Esteban Gallo, Ricard Cervera, Yehuda Shoenfeld, Mauricio Arcos-Burgos

Resultado de la investigación: Contribución a RevistaArtículo

40 Citas (Scopus)

Resumen

The multiple autoimmune syndromes (MAS) consist on the presence of three or more well-defined autoimmune diseases (ADs) in a single patient. The aim of this study was to analyze the clinical and genetic characteristics of a large series of patients with MAS. A cluster analysis and familial aggregation analysis of ADs was performed in 84 patients. A genome-wide microsatellite screen was performed in MAS families, and associated loci were investigated through the pedigree disequilibrium test. Systemic lupus erythematosus (SLE), autoimmune thyroid disease (AITD), and Sjögren's syndrome together were the most frequent ADs encountered. Three main clusters were established. Aggregation for type 1 diabetes, AITD, SLE, and all ADs as a trait was found. Eight loci associated with MAS were observed harboring autoimmunity genes. The MAS represent the best example of polyautoimmunity as well as the effect of a single genotype on diverse phenotypes. Its study provides important clues to elucidate the common mechanisms of ADs (i.e., autoimmune tautology). © Springer Science+Business Media, LLC 2012.
Idioma originalEnglish (US)
Páginas (desde-hasta)256-264
Número de páginas9
PublicaciónClinical Reviews in Allergy and Immunology
DOI
EstadoPublished - dic 1 2012

Huella dactilar

Autoimmune Diseases
Thyroid Diseases
Systemic Lupus Erythematosus
Sjogren's Syndrome
Pedigree
Autoimmunity
Type 1 Diabetes Mellitus
Microsatellite Repeats
Cluster Analysis
Genotype
Genome
Phenotype
Genes

Citar esto

Anaya, J. M., Castiblanco, J., Rojas-Villarraga, A., Pineda-Tamayo, R., Levy, R. A., Gómez-Puerta, J., ... Arcos-Burgos, M. (2012). The multiple autoimmune syndromes. A clue for the autoimmune tautology. Clinical Reviews in Allergy and Immunology, 256-264. https://doi.org/10.1007/s12016-012-8317-z
Anaya, Juan Manuel ; Castiblanco, John ; Rojas-Villarraga, Adriana ; Pineda-Tamayo, Ricardo ; Levy, Roger A. ; Gómez-Puerta, José ; Dias, Carlos ; Mantilla, Ruben D. ; Gallo, Juan Esteban ; Cervera, Ricard ; Shoenfeld, Yehuda ; Arcos-Burgos, Mauricio. / The multiple autoimmune syndromes. A clue for the autoimmune tautology. En: Clinical Reviews in Allergy and Immunology. 2012 ; pp. 256-264.
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abstract = "The multiple autoimmune syndromes (MAS) consist on the presence of three or more well-defined autoimmune diseases (ADs) in a single patient. The aim of this study was to analyze the clinical and genetic characteristics of a large series of patients with MAS. A cluster analysis and familial aggregation analysis of ADs was performed in 84 patients. A genome-wide microsatellite screen was performed in MAS families, and associated loci were investigated through the pedigree disequilibrium test. Systemic lupus erythematosus (SLE), autoimmune thyroid disease (AITD), and Sj{\"o}gren's syndrome together were the most frequent ADs encountered. Three main clusters were established. Aggregation for type 1 diabetes, AITD, SLE, and all ADs as a trait was found. Eight loci associated with MAS were observed harboring autoimmunity genes. The MAS represent the best example of polyautoimmunity as well as the effect of a single genotype on diverse phenotypes. Its study provides important clues to elucidate the common mechanisms of ADs (i.e., autoimmune tautology). {\circledC} Springer Science+Business Media, LLC 2012.",
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Anaya, JM, Castiblanco, J, Rojas-Villarraga, A, Pineda-Tamayo, R, Levy, RA, Gómez-Puerta, J, Dias, C, Mantilla, RD, Gallo, JE, Cervera, R, Shoenfeld, Y & Arcos-Burgos, M 2012, 'The multiple autoimmune syndromes. A clue for the autoimmune tautology', Clinical Reviews in Allergy and Immunology, pp. 256-264. https://doi.org/10.1007/s12016-012-8317-z

The multiple autoimmune syndromes. A clue for the autoimmune tautology. / Anaya, Juan Manuel; Castiblanco, John; Rojas-Villarraga, Adriana; Pineda-Tamayo, Ricardo; Levy, Roger A.; Gómez-Puerta, José; Dias, Carlos; Mantilla, Ruben D.; Gallo, Juan Esteban; Cervera, Ricard; Shoenfeld, Yehuda; Arcos-Burgos, Mauricio.

En: Clinical Reviews in Allergy and Immunology, 01.12.2012, p. 256-264.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - The multiple autoimmune syndromes. A clue for the autoimmune tautology

AU - Anaya, Juan Manuel

AU - Castiblanco, John

AU - Rojas-Villarraga, Adriana

AU - Pineda-Tamayo, Ricardo

AU - Levy, Roger A.

AU - Gómez-Puerta, José

AU - Dias, Carlos

AU - Mantilla, Ruben D.

AU - Gallo, Juan Esteban

AU - Cervera, Ricard

AU - Shoenfeld, Yehuda

AU - Arcos-Burgos, Mauricio

PY - 2012/12/1

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N2 - The multiple autoimmune syndromes (MAS) consist on the presence of three or more well-defined autoimmune diseases (ADs) in a single patient. The aim of this study was to analyze the clinical and genetic characteristics of a large series of patients with MAS. A cluster analysis and familial aggregation analysis of ADs was performed in 84 patients. A genome-wide microsatellite screen was performed in MAS families, and associated loci were investigated through the pedigree disequilibrium test. Systemic lupus erythematosus (SLE), autoimmune thyroid disease (AITD), and Sjögren's syndrome together were the most frequent ADs encountered. Three main clusters were established. Aggregation for type 1 diabetes, AITD, SLE, and all ADs as a trait was found. Eight loci associated with MAS were observed harboring autoimmunity genes. The MAS represent the best example of polyautoimmunity as well as the effect of a single genotype on diverse phenotypes. Its study provides important clues to elucidate the common mechanisms of ADs (i.e., autoimmune tautology). © Springer Science+Business Media, LLC 2012.

AB - The multiple autoimmune syndromes (MAS) consist on the presence of three or more well-defined autoimmune diseases (ADs) in a single patient. The aim of this study was to analyze the clinical and genetic characteristics of a large series of patients with MAS. A cluster analysis and familial aggregation analysis of ADs was performed in 84 patients. A genome-wide microsatellite screen was performed in MAS families, and associated loci were investigated through the pedigree disequilibrium test. Systemic lupus erythematosus (SLE), autoimmune thyroid disease (AITD), and Sjögren's syndrome together were the most frequent ADs encountered. Three main clusters were established. Aggregation for type 1 diabetes, AITD, SLE, and all ADs as a trait was found. Eight loci associated with MAS were observed harboring autoimmunity genes. The MAS represent the best example of polyautoimmunity as well as the effect of a single genotype on diverse phenotypes. Its study provides important clues to elucidate the common mechanisms of ADs (i.e., autoimmune tautology). © Springer Science+Business Media, LLC 2012.

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JO - Clinical Reviews in Allergy and Immunology

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SN - 1080-0549

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Anaya JM, Castiblanco J, Rojas-Villarraga A, Pineda-Tamayo R, Levy RA, Gómez-Puerta J y otros. The multiple autoimmune syndromes. A clue for the autoimmune tautology. Clinical Reviews in Allergy and Immunology. 2012 dic 1;256-264. https://doi.org/10.1007/s12016-012-8317-z