The malaria parasite’s Achilles’ heel: Functionallyrelevant invasion structures

Manuel E. Patarroyo, Martha P. Alba, Cesar Reyes, Rocio Rojas-Luna, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

6 Citas (Scopus)

Resumen

© 2015, Caister Academic Press. All rights reserved.Malaria parasites have their Achilles’ heel; they are vulnerable in small parts of their relevant molecules where they can be wounded and killed. These are sporozoite and merozoite protein conserved high activity binding peptides (cHABPs), playing a critical role in binding to and invasion of host cells (hepatocytes and erythrocytes, respectively). cHABPs can be modified by specific amino acid replacement, according to previously published physicochemical rules, to produce analogues (mHABPs) having left-handed polyproline II (PPIIL)-like structures which can modulate an immune response due to fitting perfectly into the HLA-DRβ1* peptide binding region (PBR) and having an appropriate presentation to the T-cell receptor (TCR).
Idioma originalEnglish (US)
Páginas (desde-hasta)11-20
Número de páginas10
PublicaciónCurrent Issues in Molecular Biology
EstadoPublished - ene 1 2016

Huella dactilar

Malaria
Parasites
Peptides
Merozoites
Sporozoites
T-Cell Antigen Receptor
Hepatocytes
Erythrocytes
Amino Acids
Proteins
polyproline

Citar esto

Patarroyo, Manuel E. ; Alba, Martha P. ; Reyes, Cesar ; Rojas-Luna, Rocio ; Patarroyo, Manuel A. / The malaria parasite’s Achilles’ heel: Functionallyrelevant invasion structures. En: Current Issues in Molecular Biology. 2016 ; pp. 11-20.
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The malaria parasite’s Achilles’ heel: Functionallyrelevant invasion structures. / Patarroyo, Manuel E.; Alba, Martha P.; Reyes, Cesar; Rojas-Luna, Rocio; Patarroyo, Manuel A.

En: Current Issues in Molecular Biology, 01.01.2016, p. 11-20.

Resultado de la investigación: Contribución a RevistaArtículo

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