The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris

Elizabeth Misas; Patricia Escandón; Juan G. McEwen; Oliver K. Clay

doi:10.1002/pro.3727

The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris

Título traducido de la contribución: El dominio LUFS, sus proteínas reguladoras de la transcripción y la resistencia a fármacos en el patógeno fúngico Candida auris

Elizabeth Misas
, Patricia Escandón
, Juan G. McEwen
, Oliver K. Clay

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

10 Citas (Scopus)

Resumen

El dominio LUFS (LUG/LUH, Flo8, proteína de unión a ADN monocatenario [SSBP]) es una región bien conservada y aparentemente antigua que se encuentra en diversas proteínas y taxones. Este dominio, que tiene como característica estructural más obvia una serie de tres hélices, se ha identificado en proteínas reguladoras de la transcripción de animales, plantas y hongos. Recientemente, en estas páginas (Wang et al., Protein Sci., 2019, 28:788–793), se informó la primera estructura cristalina de un dominio LUFS, para el SSBP2 humano, un represor transcripcional. Abordamos brevemente cómo los nuevos conocimientos sobre las estructuras LUFS podrían contribuir a una mejor comprensión de un importante activador transcripcional de las levaduras que contiene el dominio LUFS, Flo8, y consideramos cómo un enfoque en el dominio LUFS y su variación podría ayudarnos a comprender las etiologías de la resistencia a los fármacos en un hongo patógeno de reciente aparición, Candida auris.

Título traducido de la contribución	El dominio LUFS, sus proteínas reguladoras de la transcripción y la resistencia a fármacos en el patógeno fúngico Candida auris
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	2024-2029
Número de páginas	6
Publicación	Protein Science
Volumen	28
N.º	11
DOI	https://doi.org/10.1002/pro.3727
Estado	Publicada - sep. 10 2019

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Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Bioquímica
Biología molecular

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title = "The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris",

abstract = "The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris.",

author = "Elizabeth Misas and Patricia Escand{\'o}n and McEwen, \{Juan G.\} and Clay, \{Oliver K.\}",

year = "2019",

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T1 - The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris

AU - Misas, Elizabeth

AU - Escandón, Patricia

AU - McEwen, Juan G.

AU - Clay, Oliver K.

PY - 2019/9/10

Y1 - 2019/9/10

N2 - The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris.

AB - The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris.

UR - https://www.scopus.com/pages/publications/85073583103

UR - https://www.scopus.com/pages/publications/85073583103#tab=citedBy

U2 - 10.1002/pro.3727

DO - 10.1002/pro.3727

M3 - Research Article

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AN - SCOPUS:85073583103

SN - 0961-8368

VL - 28

SP - 2024

EP - 2029

JO - Protein Science

JF - Protein Science

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The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris

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