The impact of HIV-1 within-host evolution on transmission dynamics

Kristof Theys, Pieter Libin, Andrea Clemencia Pineda-Peña, Ann Nowé, Anne Mieke Vandamme, Ana B. Abecasis

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

25 Citas (Scopus)

Resumen

The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission.

Idioma originalInglés estadounidense
Páginas (desde-hasta)92-101
Número de páginas10
PublicaciónCurrent Opinion in Virology
Volumen28
DOI
EstadoPublicada - feb. 2018

Áreas temáticas de ASJC Scopus

  • Virología

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